Evolution and Convergence of CA-MRSA and HA-MRSA: Is PVL Still a Discriminating Factor?
Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant global pathogen responsible for both healthcare-associated and community-associated infections. Historically, the presence of Panton–Valentine leukocidin (PVL) served as a key molecular marker distinguishing community-associated MRSA (CA-MRSA) from hospital-associated MRSA (HA-MRSA). However, increasing evidence of genetic convergence between these lineages challenges the reliability of PVL as a discriminating factor. […]
