Zebrafish Strains – A Brief Account of the Experimental Model

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Zebrafish, though tiny in size has proven it as an important scientific tool to conduct research and understand the various biological phenomena and system. Several zebrafish strains are available which are contributing differently in deepening our understanding. A number of wild type strains are present which have originated in the various parts of the world with its own history of origin. the most common wild type strains of zebrafish are: AB, WIK and TU. All these wild type strains share same morphological features, but with genetic differences. Gradually, under laboratory conditions different mutant versions with specific morphological and biological features developed and continued as experimental model in different laboratories of the world and gained importance in experimental usages. Among them TL, Absolute, Golden, Nacre etc. are the mutant strains widely used in different biological experiments and studies. Present review will discuss on the origin, morphological, genetic and other specialists of these strains to account a comprehensive idea about the animal model and its usages.

Redesign of Interactive Exhibitions in Mundo Fútbol

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This research project was developed in collaboration with the interactive center Mundo Fútbol, a company dedicated to educational entertainment through interactive sports exhibits. The main objective was the redesign of three of its most representative interactive exhibits: Compare Your Jump, Test Your Power, and Measure Your Speed. These exhibits, which are central to the visitor experience, showed significant deficiencies in material durability, ease of use, maintenance, and visual appeal due to prolonged use and a lack of technical updates for over a decade.

The research was structured based on the Design Thinking methodology, which allowed for a deep understanding of the needs of both the users and the Mundo Fútbol staff responsible for the transportation, installation, and operation of the exhibitions. The process was carried out in five stages: empathize, define, ideate, prototype, and test, supported by complementary tools such as the Ishikawa diagram, SCAMPER, and brainstorming. These tools helped facilitate the identification of root problems and the generation of innovative solutions.

Each exhibit was addressed individually, with a detailed analysis of its operation, structure, components, user interaction, and usage conditions. As part of the redesign, structural, functional, and aesthetic improvements were proposed and modeled using SolidWorks software, producing technical drawings, 3D models, and photorealistic renders of the new proposals. Additionally, structural simulations with static load analysis were conducted using materials such as ABS plastic and ASTM A-36 steel, in order to validate the strength, safety, and efficiency of each design.

The results demonstrate significant improvements in ergonomics, structural resistance, ease of maintenance, and user experience, while also reducing setup times and transportation requirements. This research not only provides technical solutions tailored to Mundo Fútbol’s needs but also establishes a replicable methodology for the development of modern, sustainable, and user-centered interactive exhibits within the field of industrial design and engineering.

Exponential Organizations and Disruptive Innovation

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Exponential Organizations (ExOs) represent a new generation of enterprises that leverage digital technologies, scalable business models, and innovative organizational structures to achieve rapid growth and transformative impact. Closely linked to this phenomenon is disruptive innovation, which reshapes industries by introducing solutions that redefine value creation and render traditional business models obsolete. This paper examines the conceptual foundations, characteristics, and mechanisms of Exponential Organizations, analyzes their relationship with disruptive innovation, and explores how emerging technologies such as artificial intelligence, blockchain, the Internet of Things, and advanced connectivity accelerate this dynamic. Through an extensive review of the literature and illustrative case examples, the study highlights how ExOs amplify disruption, create new markets, and challenge incumbents. The paper concludes with strategic recommendations for organizations seeking to thrive in an era of exponential change.

The Association between Sleep Quality and Primary Dysmenorrhea Among Female Engineering Students at Nusa Cendana University: A Cross-Sectional Study

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Background: Primary dysmenorrhea is a common gynecological condition among young women and may significantly impair daily activities and academic performance. Sleep quality has been suggested as an important modifiable risk factor, as poor sleep may increase inflammatory mediators and prostaglandin production involved in menstrual pain. However, findings regarding the relationship between sleep quality and primary dysmenorrhea remain inconsistent across populations.

Objective: To determine the association between sleep quality and the incidence of primary dysmenorrhea among female engineering students at Nusa Cendana University.

Methods: This analytical observational study employed a cross-sectional design. A total of 60 female students who met the inclusion and exclusion criteria were recruited using purposive sampling. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), while the severity of dysmenorrhea was evaluated using the WaLIDD score. Data were analyzed using univariate and bivariate analyses. The Mann–Whitney test was applied to determine the association between sleep quality and primary dysmenorrhea.

Results: The majority of respondents (.7%) had poor sleep quality. Primary dysmenorrhea was reported by 86.7% of participants, with moderate severity being the most common (45%), followed by mild (33.3%) and severe dysmenorrhea (8.3%). Statistical analysis demonstrated a significant association between sleep quality and the incidence of primary dysmenorrhea (p < 0.001).

Conclusion: Poor sleep quality is significantly associated with the occurrence of primary dysmenorrhea among female engineering students at Nusa Cendana University. Improving sleep quality may represent a potential non-pharmacological approach to reducing menstrual pain in this population.

The Role of Product Innovation on Purchasing Decisions with Iconic Ethnical Products as a Mediating Variable among Pamekasan Batik Artisans

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This study aims to examine the role of product innovation in influencing purchasing decisions with iconic ethnical product as a mediating variable among consumers of Pamekasan batik. Using a quantitative approach, data were collected through a structured questionnaire distributed to Pamekasan batik consumers. The data were analyzed using Structural Equation Modeling (SEM) to test both direct and indirect relationships among variables. The results indicate that product innovation has a significant positive effect on iconic ethnical product, but does not directly influence purchasing decisions. In contrast, iconic ethnical product has a significant positive effect on purchasing decisions and plays a mediating role in the relationship between product innovation and purchasing decisions. These findings suggest that product innovation contributes to purchasing decisions only when it strengthens the iconic and ethnical characteristics of the product, such as cultural symbolism, distinctive motifs, and local identity. The study highlights that consumers of Pamekasan batik place greater emphasis on symbolic value and cultural meaning rather than product novelty alone. The results support Consumer Culture Theory, emphasizing that purchasing decisions for cultural products are shaped by culturally constructed meanings. Practically, this study implies that Pamekasan batik artisans should orient product innovation strategies toward reinforcing iconic ethnical values to enhance consumer purchasing decisions.

The Effect of Good Corporate Governance on Indications of Financial Statement Fraud in State-Owned Enterprises Listed on The Indonesian Stock Exchange for The 2020-2024 Period

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The purpose of this study was to analyze how Good Corporate Governance mechanisms, as represented by the the board of commissioners, audit committee, institutional ownership, and whistleblowing system, affect indications of financial statement fraud in state-owned enterprises listed on the Indonesia Stock Exchange during the 2020-2024 period. This research was conducted on state-owned enterprises listed on the Indonesia Stock Exchange. Data were obtained through the official website of the Indonesia Stock Exchange at www.idx.com. The sampling technique used was purposive sampling, resulting in a sample of 17 state-owned enterprises listed on the Indonesia Stock Exchange during the 2020-2024 period. The analysis was carried out using panel data multiple linear regression with the assistance of  EViews statistical software. The results of this study indicate that the audit committee variable has an effect on indications of financial statement fraud. Meanwhile, the board of commissioners, institutional ownership, and whistleblowing system variables do not have a significant effect on indications of financial statement fraud.

Anaesthesia-Related Child Mortality in a Niger Delta Tertiary Hospital: 5-Year Impact of Paediatric Anaesthesia Training

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Background: A rising under-five perioperative death occurring especially in sub-Saharan Africa, despite global decline in child mortality over the last decade, necessitates a review of the contribution from anaesthesia-related causes.

Objective: To analyze the 5-year impact of Paediatric Anaesthesia Fellowship on anaesthesia-related child deaths in the University of Port Harcourt Teaching Hospital (UPTH).

Method: A five-year survey of all anaesthetic interventions and outcomes in children aged 0 to 5 years, in UPTH, was undertaken. Data including general or loco-regional anaesthesia for elective/emergency surgeries, sedation-analgesia for diagnostic radiology, the indications, perioperative critical events/child deaths up to 24 hours following anaesthesia, and their causes, were obtained from the registers and records of the relevant units in the UPTH, after ethical approval.

Results: Totally, 1596 anaesthetic interventions [987 (61.842%) electives; 609 (38.158%) emergencies] and outcomes were reviewed. General anaesthesia with endotracheal tube (GA + ETT) placement was the most frequent form of anaesthesia, administered to 1,075 (67.36%), and perioperative laryngospasm [49 (3.07%)] was the ranking critical event, followed by hypoxaemia, delayed recovery and difficult tracheal intubation respectively as the second, third and fourth, with the corresponding values of 34 (2.13%), 33 (2.07%) and 25 (1.57%); anaesthesia-related mortality was 1 (0.06%), occurring postoperatively from respiratory failure, following GA + ETT placement for elective abdominoplasty in a child with Prune-belly Syndrome.

Conclusion: Within the five-year period in this survey, anaesthesia-related child mortality was 1 (0.06%), occurring postoperatively from respiratory failure.

Effectiveness of Structured Communication Tools for Discussing Goals of Care in Cancer Care Settings: A Systematic Review

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Background and aim: Structured communication tools have been increasingly adopted in cancer care to support discussions on goals of care (GOC), symptom management, and psychosocial needs. However, evidence regarding their effectiveness across outcomes remains fragmented. The study aims to synthesize evidence on the effectiveness of structured communication tools used in cancer care settings for discussing goals of care, with a focus on patient, caregiver, and system-level outcomes.

Method: A comprehensive search was conducted in databases including PubMed, Google Scholar, Clinical Key, and Cochrane Library from January 2000 to July 2025. Eligible studies included quasi-experimental trials, Randomized controlled trials (RCTs), cluster randomized trials, and cohort studies evaluating structured communication interventions. Two reviewers independently screened articles, extracted data, and assessed the Risk of bias using the ROB-I, ROB-I (Cluster), ROBINS-I V2, and ROBINS-E tools. Outcomes of interest were broadly encompassed, including quality of life(QoL), psychological status, patient satisfaction, decisional conflict, hospice utilization, and advance care planning. Due to heterogeneity in study designs and outcomes, a narrative synthesis was performed.

Results: From an initial pool of 310 articles, 25 studies met the inclusion criteria. SCTs varied widely and included FLEX Care, end-of-life (EOL) care planning, communication training, Loop intervention, Serious Illness Care Program, PCAD pathway, GOC conversation, and an adapted end-of-life care module, etc. Studies reported improved QoL (n=10), psychological status (n=3), patient/staff/caregiver satisfaction (n=3), decisional conflict (n=2), hospice utilization, and advance care planning (n=7). Mean scores for psychological distress participants receiving FLEX Care®-enhanced psychosocial intervention experienced a significant reduction in psychological distress compared to participants in the control setting (p<0.001). EOL discussions were associated with lower rates of ventilation (AOR=0.26, 95%CI=0.08-0.83), resuscitation (AOR=0.16, 95%CI=0.03-0.80), ICU admission (AOR=0.35, 95%CI=0.14-0.90), and earlier hospice enrolment (AOR=1.58, 95% CI=1.04-2.63). while longer hospice stays were associated with better patient QoL (p=0.01)

Conclusion: SCTs appear effective in improving the goals-of-care discussions in cancer settings, with benefits in care alignment and patient satisfaction. Implementation strategies and clinician training remain critical components for success.

 

Comparison of Serum Vitamin D Levels Between Arthralgia and Non-Arthralgia Groups Among Indoor Workers with Suspected Knee Osteoarthritis in Kupang City, Indonesia

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Background: Osteoarthritis is a degenerative joint disease commonly affecting the knee and often begins with joint pain or arthralgia. Vitamin D deficiency has been suggested as a contributing factor to musculoskeletal pain and cartilage metabolism disorders. Indoor workers may be at increased risk due to limited sunlight exposure and prolonged sitting duration.

Objective: To compare serum vitamin D levels between arthralgia and non-arthralgia groups among indoor workers with suspected knee osteoarthritis in Kupang City.

Methods: An observational analytic study with a cross-sectional design was conducted among 46 indoor workers from several government institutions in Kupang City. Participants were assessed through anamnesis, body mass index measurement, and evaluation of knee pain using the Visual Analogue Scale (VAS). Serum 25-hydroxyvitamin D levels were measured using the electrochemiluminescence immunoassay (ECLIA) method. Subjects were classified into arthralgia and non-arthralgia groups. Data were analyzed using the independent t-test.

Results: All participants were female, aged 18–59 years. Of the 46 respondents, 22 were classified as having arthralgia and 24 as non-arthralgia. A significant difference in serum 25-hydroxyvitamin D levels was observed between the two groups (p < 0.05). The arthralgia group showed a lower mean serum vitamin D level (17.2 ± 2.94 ng/mL) with a mean VAS score of 5.83, indicating moderate pain. In contrast, the non-arthralgia group had a higher mean serum vitamin D level (24.1 ± 2.51 ng/mL) with a VAS score of 0.

Conclusion: There was a significant difference in serum vitamin D levels between arthralgia and non-arthralgia indoor workers with suspected knee osteoarthritis in Kupang City, with lower vitamin D levels observed in the arthralgia group.

The Influence of Work Experience and Job Performance on Career Development Mediated by Career Training at the Ministry of Foreign Affairs and Cooperation of Timor-Leste in Indonesia.

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This study aims to analyze the influence of Work Experience (X1) and Job Performance (X2) on Career Development (Y), with Career Training (Z) as a mediating variable, at the Ministry of Foreign Affairs and Cooperation of Timor-Leste in Indonesia. Using a quantitative approach and a census method (saturated sampling) involving 62 employees, data were analyzed using Path Analysis (Partial Least Squares) based on Herzberg’s Two-Factor Theory. The results demonstrate that Work Experience (X1) has a significant positive effect on Career Development (Y), whereas Job Performance (X2) does not show a direct significant impact on Career Development (Y). Furthermore, while Career Training (Z) does not significantly mediate the relationship between Work Experience (X1) and Career Development (Y), it serves as a crucial mediating variable between Job Performance (X2) and Career Development (Y). These findings suggest that while practical experience naturally fosters career growth, high job performance requires structured training programs to effectively translate into professional advancement. Therefore, the organization should focus on enhancing training initiatives to bridge the gap between employee performance and career progression.