Dilated Cardiomyopathy and Severe Functional Valvular Regurgitation in a Young Adult with Prior Childhood Chemotherapy: Progressive Ventricular Dysfunction Despite Surgical Correction and Optimal Medical Therapy
Background: Late cardiotoxicity is a recognized complication in survivors of childhood cancer treated with potentially cardiotoxic agents, particularly anthracyclines. These therapies may cause progressive myocardial injury through mechanisms involving oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis. Over time, this process can lead to ventricular remodeling, dilated cardiomyopathy, and heart failure. Advanced ventricular dilation frequently results […]
