Articles

Exercise During Chemotherapy in Colorectal Cancer: A Systematic Review

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This study investigates the effects of structured exercise on treatment tolerance, physical function, and frailty-related outcomes in adults with colorectal cancer (CRC) receiving chemotherapy, with separate appraisal for older patients to evaluate its potential to support safe and effective treatment delivery. Using a Systematic Review methodology, this study synthesized research published between January 2021 and March 2026 from PubMed, Taylor & Francis Online, and SAGE Journals searched (1 May–1 June 2026). Data were analyzed using a narrative synthesis approach, focusing on tolerance, function, fatigue, frailty, quality of life, adherence, and safety, with bias assessed via RoB 2 and ROBINS-I. The findings indicate that of 701 studies screened, 7 reports (5 cohorts) were eligible, with no serious exercise-related adverse events. A geriatric intervention with supervised physiotherapy showed higher chemotherapy completion than usual care (45% vs 28%, p=0.037), though not isolated from concurrent nutritional therapy and medication review. Unsupervised home-based resistance training did not improve relative dose intensity, while function improved most consistently with supervised or progressive resistance programs. Unlike previous review studies, this research integrates tolerance, function, frailty, and safety outcomes into a unified narrative framework specific to the CRC chemotherapy population. The study concludes that structured exercise appears feasible and may preserve physical function, though its independent contribution to treatment tolerance remains undetermined and frailty-specific evidence is limited to one geriatric cohort. Additionally, further research is required to compare exercise delivery models using adequately powered trials and standardized frailty/tolerance measures.

Chemical synthesis and applications of Gold nanoparticles

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The range of scientific and technical uses for nanoparticles makes it evident how important nanotechnology is in today’s world. Gold nanoparticles are among the many metal nanoparticles that can be produced using a variety of methods. This review article emphasizes the fundamental methods of chemical synthesis for gold nanoparticles, exploring their production processes and diverse applications. The data for the research was gathered through a review of existing literature. The Brust-Schiffrin method is a significant approach for synthesizing gold nanoparticles (AuNPs). In this technique, two reaction pathways are employed to achieve an efficient surface reaction during the formation and growth process. AuCl4− is transferred from the aqueous phase to toluene and subsequently reduced by sodium borhydrate (NaBH4) in the presence of dodecanethiol. The adaptable surface chemistry of AuNPs enables them to be coated with small molecules, polymers, and biological recognition molecules, thus expanding their scope of use. The size of AuNPs can be regulated during synthesis and functionalization with various chemical groups. They have the ability to accumulate in tumor cells, exhibit optical scattering, and serve as probes for microscopic studies of harmful cells. Additionally, AuNPs are employed in cancer therapy and diagnosis. Furthermore, they hold significant promise in catalysis, as their surfaces facilitate interactions between reactants and the catalytically active sites on gold nanoparticles.

Effect of Chemotherapy on Protein Level of Under Treatment Cancer Sufferers

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Introduction: Cancer staging is an important aspect of cancer management and directly affects the treatment plan of the patient.  There are several protein tumour markers that helps in the diagnosis as well as prognosis of cancer patients.

Aim:  The current study aims to evaluate the total protein value from the serum samples of selected cancer patients and see any pattern with different stages of patients.

Materials & Method:  Total proteins were measured by IR-VS spectroscopy method and compared in different patients.

Result:  The spectrophotometric analysis of the collected serum samples showed that chemotherapy induced total protein loss is associated with dysregulation in serum proteins and electrolytes. Total protein is a significant marker that can help determine the tumour staging in cancer patients and thus can act as a prognostic marker also.  It is a simple, non-invasive and cost effective method of analysis.

A Review on the Prevalence and Management of Colorectal Cancer

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Cancer had become a common disease worldwide and cancer related death is also increasing in various parts of the world in spite of increased screening and diagnostic facilities available for early detection of cancer and availability of advanced care system. Changes in the diet and life style had led to alteration in the microenvironment of the cells leading to genetic changes and mutation. In this review, Colorectal cancer prevalence, risk factors for the development of colorectal cancer, pathogenesis, diagnosis and various treatment modalities available are discussed here.