Improvement in Knee Osteoarthritis and Weight Loss Through Integrative Ayurvedic Management: A Case Study

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​ Background: Osteoarthritis (OA) is the most prevalent form of arthritis worldwide, causing significant disability. Obesity further increases the risk and severity of Osteoarthritis. Current pharmacological treatments like NSAIDs often fail to halt disease progression and are associated with adverse effects. Integrative Ayurvedic management offers a holistic alternative for addressing underlying metabolic and inflammatory contributors to Osteoarthritis.

Methods: A 45-year-old obese female with moderate bilateral knee osteoarthritis, fatty liver, and other systemic complaints underwent a structured Ayurvedic treatment regimen. This included personalized Panchakarma therapies (Snehan, Swedan, PRDA, Janu Basti, Shali Shashti Sweda), oral Rasayana medications, a controlled 800-calorie high-protein/high-fiber diet, and prescribed physical exercise.

Results: The patient showed progressive improvement in functional mobility measured via the KOOS score (from 9% to 67%) and reported significant symptomatic relief. Weight reduction was clinically significant and associated with improved joint mobility and reduced pain. Fatty liver indicators and general systemic health also improved without adverse pharmacological side effects.

Conclusions: The integrative Ayurvedic approach provided holistic, patient-centered care with notable improvements in Osteoarthritis symptoms, body weight, and comorbid conditions. These outcomes support the role of Ayurveda as a complementary modality in managing musculoskeletal and metabolic disorders.

Olanzapine-Induced Cholestatic Liver Injury Mimicking Obstructive Hepatobiliary Disease: A Case Report

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Drug-induced liver injury can present as biliary obstruction which can lead to difficulties interpreting cholestatic liver enzyme elevations. This report describes a middle-aged woman with bipolar disorder, Hashimoto thyroiditis, fatty liver disease, and a prior cholecystectomy with markedly elevated liver enzymes following a recent increase in her olanzapine dose. Laboratory testing showed an alkaline phosphatase level exceeding 1000 U/L and a gamma-glutamyl transferase level of 768 U/L, with mild elevations in aminotransferases. Further testing showed that the elevated alkaline phosphatase was mainly hepatic in origin. Ultrasound and magnetic resonance cholangiopancreatography showed hepatomegaly but no evidence of bile duct dilatation or choledocholithiasis. Viral hepatitis and autoimmune causes were investigated and workup was unrevealing. Olanzapine was discontinued due to concern for drug-induced liver injury, leading to an improvement in her liver function tests, with alkaline phosphatase decreasing to 406 U/L at outpatient follow-up. Due to the timing of the dosage increase, the ability of olanzapine to cause cholestatic injury, the negative findings on imaging, and the improvement after discontinuing olanzapine, drug-induced cholestatic liver injury was considered the most likely diagnosis. This case shows that olanzapine can mimic an obstructive pattern, and that cholestatic drug injury remains a diagnosis of exclusion, especially after biliary surgery or when occult obstruction is still suspected.

Blood Without a Source: A Diagnostic Challenge in Recurrent Oropharyngeal Bleeding

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Oropharyngeal bleeding may be difficult to distinguish from hemoptysis when the source of blood is not apparent, potentially prompting extensive evaluation for pulmonary or gastrointestinal causes. This report describes an 82-year-old woman who experienced recurrent episodes of bright red blood mixed with saliva over approximately two weeks, without associated coughing or vomiting. Initial evaluation did not identify a bleeding source, and the episodes resolved spontaneously before otolaryngologic examination. Flexible nasolaryngoscopy revealed mild nasal mucosal irritation without active bleeding or an identifiable lesion. Prominent pulsation of the posterior pharyngeal wall raised suspicion for a retropharyngeal carotid course, although this finding was not confirmed by vascular imaging. Minor mucosal trauma was considered a possible explanation, but the exact source of bleeding remained undetermined. This case highlights the importance of localizing unexplained oral bleeding and recognizing potential vascular anatomical variants during examination of the posterior pharynx.

Factors Affecting the Decision to Adopt Stray Dogs Instead of Purchasing in Bangkok, Thailand

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The decision to adopt stray dogs rather than purchase them has become a growing concern in Bangkok, where 100,000 stray dogs live on the streets despite a thriving pet ownership culture. As pet humanization trends expand, purchasing pets from breeders has become increasingly normalized among residents. This study aims to investigate the factors affecting the decision to adopt stray dogs instead of purchasing among Bangkok residents, to understand what prevents positive attitudes from becoming actual adoption behavior. Using a structured questionnaire, we collected responses from 279 participants using a 5-point Likert scale, assessing their perceptions toward stray animal adoption and the key factors influencing their decision to adopt or purchase. Our findings revealed that Bangkok residents showed generally positive attitudes toward stray animal adoption; however, their responses also indicated concerns and preferences that may affect stated willingness to adopt. One potential explanation is that while Thailand’s Buddhist cultural values create a broadly compassionate outlook toward animals across all demographic groups, social barriers such as preference for specific breeds and negative perceptions of stray animal health prevent these sentiments from translating into adoption behavior. These findings provide direction for policymakers and animal welfare organizations seeking to design more targeted and effective adoption promotion strategies in Bangkok.

Role of Some Immunological Cytokines in H. pylori-infected Patients in Relation to Iron Indices Levels

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Background:  The human stomach is colonized by Helicobacter pylori (H. pylori), a Gram-negative bacterium. A chronic H. pylori infection can lead to a number of gastrointestinal disorders, including gastric cancer.

Objective: The study aimed to investigate serum level IL6, IL1β, and TNF-a with iron status to assess the severity of infection.

Methods: Case control study design involved 100 participants (50 patients and 50 control), for each groups, rapid H. pylori stool antigen test, IgG, serum IL6, IL1β, and serum TNF-α were estimated along with iron parameters.

Results:  Immunological marker concentrations in the patient and control groups. All tested indices, comprising IgG, IL-6, IL-1β, and TNF-α, showed statistically notable increase in comparison with control (p< 0.001). Parameters related to iron were highly skewed such as serum iron, ferritin, total iron binding capacity (TIBC), serum iron, and transferrin value (p < 0.001).

Conclusion:  These indicators can be used to diagnose and/or monitor the course of an infection since H. pylori infection can drastically affect the diagnostic indicators and the markers typically used to measure the degree of inflammation during infection.

Artificial Intelligence in Allied Health Practice: Current Evidence, Emerging Applications, And Implications for Patient Safety

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Artificial intelligence (AI) is moving from experimental research into routine healthcare workflows, including diagnostic support, clinical documentation, rehabilitation, laboratory medicine, medical imaging, patient education, and service management. Allied health professionals are increasingly involved in these AI-enabled pathways, yet evidence and implementation guidance are often concentrated in physician-led specialties. This narrative review synthesises current evidence on the use of AI across allied health practice and examines implications for patient safety, professional accountability, education, and health equity. Literature from peer-reviewed journals and authoritative guidance was considered, with emphasis on clinical applications, implementation barriers, bias, explainability, human-AI interaction, and generative AI. Current evidence supports potential benefits such as workflow support, image interpretation, pattern recognition, personalised rehabilitation, laboratory decision support, documentation assistance, and improved access to health information. However, technical performance alone does not establish clinical effectiveness or safety. Dataset shift, hidden bias, automation bias, inaccurate generated content, privacy risks, poor interoperability, insufficient local validation, and unclear responsibility can introduce new failure modes. Safe adoption should include a defined intended use, representative validation, transparent performance monitoring, user training, incident reporting, privacy safeguards, human oversight, and periodic re-evaluation after deployment. The review concludes that AI has meaningful potential across allied health practice, but sustainable adoption depends on evidence-based governance and continuous patient-safety monitoring rather than technology adoption alone.

Effect of Joint Mobilization Versus Soft Tissue Mobilization Along with Conventional Exercise on Pain, Quality of Life and Hip Range of Motion in Patients with Femoroacetabular Impingement Syndrome

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Background: Femoroacetabular impingement syndrome (FAIS) is a clinically important hip disorder that may contribute to the development of early hip osteoarthritis. It is frequently identified in physically active young and middle-aged adults, with symptomatic presentations commonly occurring in individuals between 20 and 40 years of age.

Methods: Twenty individuals diagnosed with femoroacetabular impingement syndrome who fulfilled the predetermined selection criteria were recruited for the study. The participants were randomly allocated into two equal groups. Group A received joint mobilization combined with conventional exercise, whereas Group B received soft tissue mobilization combined with conventional exercise. Pain intensity was assessed using the Numeric Pain Rating Scale (NPRS), hip-related functional status was evaluated using the Hip Outcome Score (HOS), and hip internal rotation range of motion was measured using a goniometer.

Result: Statistically significant improvements were observed in both groups for pain intensity, Hip Outcome Score, and hip internal rotation range of motion following the intervention. Between-group analysis also demonstrated a statistically significant difference in the post-intervention outcomes, with Group A showing greater improvement compared with Group B.

Conclusion: Both treatment approaches were associated with improvements in pain, hip-related functional outcomes, and hip internal rotation range of motion in individuals with FAIS. However, joint mobilization combined with conventional exercise demonstrated greater improvements compared with soft tissue mobilization combined with conventional exercise in the present study. These findings suggest that joint mobilization combined with conventional exercise may be a beneficial conservative physiotherapy approach for individuals with FAIS.

Evaluating The Effectiveness of Pelvic Clock Exercise Versus 90-90 Hemibridge with Ball and Balloon Techniques Along with Conventional Therapy on Pain and Quality of Life in Female College Students with Primary Dysmenorrhea

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Background: Primary dysmenorrhea is a common gynecological condition in young women, characterized by cramping lower abdominal pain during menstruation. It begins in adolescence and adversely affects daily activities, academic performance, and quality of life. Associated symptoms include low back pain, fatigue, headache, nausea, and mood disturbances. Exercise therapy is widely used to reduce symptoms. This study aims to evaluate the effectiveness of pelvic clock exercise versus 90–90 hemibridge with ball and balloon technique, along with conventional therapy, on pain and quality of life.

Methods: A comparative study conducted on 30 female college students aged 18–25 years with primary dysmenorrhea. The subjects were divided into two groups. Group A received pelvic clock exercise with conventional therapy, Group B received 90–90 hemi-bridge with ball and balloon technique with conventional therapy. The treatment duration was 45-60 minutes, 3 times /weeks for 4 weeks.  Pain was assessed by Visual Analogue Scale (VAS) and severity and quality of life were assessed by WaLIDD questionnaire before and after treatment.

Result: Using an unpaired comparison of post-test values showed significant improvement in Group B than Group A, with t-value of VAS scale is 5.136.  and WaLIDD questionnaire is 4.431 respectively.

Conclusion: The study concludes that there is notable improvement in 90-90 hemibridge ball and balloon technique along with conventional therapy was found to be more effective in reducing pain and improvement in quality of life in individual with primary dysmenorrhea.

Exercise During Chemotherapy in Colorectal Cancer: A Systematic Review

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This study investigates the effects of structured exercise on treatment tolerance, physical function, and frailty-related outcomes in adults with colorectal cancer (CRC) receiving chemotherapy, with separate appraisal for older patients to evaluate its potential to support safe and effective treatment delivery. Using a Systematic Review methodology, this study synthesized research published between January 2021 and March 2026 from PubMed, Taylor & Francis Online, and SAGE Journals searched (1 May–1 June 2026). Data were analyzed using a narrative synthesis approach, focusing on tolerance, function, fatigue, frailty, quality of life, adherence, and safety, with bias assessed via RoB 2 and ROBINS-I. The findings indicate that of 701 studies screened, 7 reports (5 cohorts) were eligible, with no serious exercise-related adverse events. A geriatric intervention with supervised physiotherapy showed higher chemotherapy completion than usual care (45% vs 28%, p=0.037), though not isolated from concurrent nutritional therapy and medication review. Unsupervised home-based resistance training did not improve relative dose intensity, while function improved most consistently with supervised or progressive resistance programs. Unlike previous review studies, this research integrates tolerance, function, frailty, and safety outcomes into a unified narrative framework specific to the CRC chemotherapy population. The study concludes that structured exercise appears feasible and may preserve physical function, though its independent contribution to treatment tolerance remains undetermined and frailty-specific evidence is limited to one geriatric cohort. Additionally, further research is required to compare exercise delivery models using adequately powered trials and standardized frailty/tolerance measures.

Protective effects of vitamin E and vitamin C against cisplatin nephrotoxicity in female Wister rats

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Cisplatin (CP) is a potent anticancer agent used in cancer treatment. However, Cisplatin had ability to induce multiorgan toxicity including nephrotoxicity. This study aims to investigate the effect of vitamin E (Vit. E) and Vitamin C (vit. C) on nephrotoxicity induced by cisplatin in female rats.

Twenty Female white albino rats were divided to four groups, control, cisplatin, vit. E + cisplatin and vit. C + cisplatin. Cispatin (8 mg/kg as a single dose on the day on and second dose at 14 experimental day.vit. E was administered Intraperitoneal injection 3 days prior to cisplatin (8 mg/kg, i.p) injection two does same process for two weeks with two-week rest period. vitamin C (200 mg/kg), were administered Intraperitoneal injection 3 days prior to cisplatin (8 mg/kg, i.p) injection two does same process for two weeks with two-week rest period. The result of this study administration of cisplatin induced Necrosis of epithelial cells of renal tubules in cortex area led to form spaces filled with inflammatory cells forming a cluster in affected areas in the cisplatin treated group compared with vit. E + Cisplatin treated group which reduced nephrotoxicity by antioxidant activity of vitamin against cisplatin induced oxidative stress in these rats. However, vit. C + Cisplatin treated group showed mild nephroprotection. Necrosis of epithelial cells was observed in renal tubules with infiltration of inflammatory cells that formed small cluster near the glomerulus in cortex area. The study findings indicated that vitamin E exert protective effects against CP-induced nephrotoxicity, a finding which requires larger studies for confirmation. cisplatin treatment alone induced the upregulation of cytokeratin-8 (CK-8), a marker of tubular injury, co-treatment with Vit.E attenuated this effect, indicating protection of renal tubular integrity. Also,cisplatin treatment group showed positive expression of vimentin in cortical convoluted renal tubules and normal expression in glomerulus.