Role of Some Immunological Cytokines in H. pylori-infected Patients in Relation to Iron Indices Levels
Background: The human stomach is colonized by Helicobacter pylori (H. pylori), a Gram-negative bacterium. A chronic H. pylori infection can lead to a number of gastrointestinal disorders, including gastric cancer.
Objective: The study aimed to investigate serum level IL6, IL1β, and TNF-a with iron status to assess the severity of infection.
Methods: Case control study design involved 100 participants (50 patients and 50 control), for each groups, rapid H. pylori stool antigen test, IgG, serum IL6, IL1β, and serum TNF-α were estimated along with iron parameters.
Results: Immunological marker concentrations in the patient and control groups. All tested indices, comprising IgG, IL-6, IL-1β, and TNF-α, showed statistically notable increase in comparison with control (p< 0.001). Parameters related to iron were highly skewed such as serum iron, ferritin, total iron binding capacity (TIBC), serum iron, and transferrin value (p < 0.001).
Conclusion: These indicators can be used to diagnose and/or monitor the course of an infection since H. pylori infection can drastically affect the diagnostic indicators and the markers typically used to measure the degree of inflammation during infection.