Articles

Chemical synthesis and applications of Gold nanoparticles

The range of scientific and technical uses for nanoparticles makes it evident how important nanotechnology is in today’s world. Gold nanoparticles are among the many metal nanoparticles that can be produced using a variety of methods. This review article emphasizes the fundamental methods of chemical synthesis for gold nanoparticles, exploring their production processes and diverse applications. The data for the research was gathered through a review of existing literature. The Brust-Schiffrin method is a significant approach for synthesizing gold nanoparticles (AuNPs). In this technique, two reaction pathways are employed to achieve an efficient surface reaction during the formation and growth process. AuCl4− is transferred from the aqueous phase to toluene and subsequently reduced by sodium borhydrate (NaBH4) in the presence of dodecanethiol. The adaptable surface chemistry of AuNPs enables them to be coated with small molecules, polymers, and biological recognition molecules, thus expanding their scope of use. The size of AuNPs can be regulated during synthesis and functionalization with various chemical groups. They have the ability to accumulate in tumor cells, exhibit optical scattering, and serve as probes for microscopic studies of harmful cells. Additionally, AuNPs are employed in cancer therapy and diagnosis. Furthermore, they hold significant promise in catalysis, as their surfaces facilitate interactions between reactants and the catalytically active sites on gold nanoparticles.

Effect of Chemotherapy on Protein Level of Under Treatment Cancer Sufferers

Introduction: Cancer staging is an important aspect of cancer management and directly affects the treatment plan of the patient.  There are several protein tumour markers that helps in the diagnosis as well as prognosis of cancer patients.

Aim:  The current study aims to evaluate the total protein value from the serum samples of selected cancer patients and see any pattern with different stages of patients.

Materials & Method:  Total proteins were measured by IR-VS spectroscopy method and compared in different patients.

Result:  The spectrophotometric analysis of the collected serum samples showed that chemotherapy induced total protein loss is associated with dysregulation in serum proteins and electrolytes. Total protein is a significant marker that can help determine the tumour staging in cancer patients and thus can act as a prognostic marker also.  It is a simple, non-invasive and cost effective method of analysis.

A Review on the Prevalence and Management of Colorectal Cancer

Cancer had become a common disease worldwide and cancer related death is also increasing in various parts of the world in spite of increased screening and diagnostic facilities available for early detection of cancer and availability of advanced care system. Changes in the diet and life style had led to alteration in the microenvironment of the cells leading to genetic changes and mutation. In this review, Colorectal cancer prevalence, risk factors for the development of colorectal cancer, pathogenesis, diagnosis and various treatment modalities available are discussed here.