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The Therapeutic Promise of Citrus limon: A Review of its In-Vitro Antioxidant and Anti-Inflammatory Effects

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Citrus plants, members of the Family Rutaceae have long been utilized in Traditional Indian medicine for the treatment of scurvy, Rheumatism , stomach ailments, diarrhea ,and  liver disorders. In addition to their therapeutic applications, Citrus plants are well known for their potent antioxidant properties, underscoring their significance in both Ethnomedicine and modern pharmacological research. Citrus essential oils are fascinating because they sit at the intersection of botany, chemistry and human health. the Rutaceae family, with its rich diversity has given us plants whose oils are aromatic and also pharmacologically active.  What makes citrus oils particularly valuables is their complex  Phytochemical composition-mainly Terpenes {like limonene, Aldehydes ,Alcohols, Esters, Flavonoids } these mixture of compounds are known for both the Organoleptic properties { Flavour, fragrance} and the bioactivities like Antibacterial, anticancer, anti-inflammatory, antioxidant properties.  The study has an objective to investigate the  composition of phytochemicals in citrus limon leaf powder and evaluate their potential pharmacological activities  majorly antioxidant  and anti-inflammatory activity by evaluating their chemical constituents and carrying out testing procedures in various applications, the review highlights the importance of citrus limon leaves as a sustainable source of natural bioactive compounds. Citrus Genus are the most cultivated fruit crops ,rich in carotenoids,  Flavonoids , and many other bioactive compounds of nutritional and nutraceutical values.

Potential of Aloin B Compound and its Derivatives as Type-2 Antidiabetic

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Type-2 diabetes mellitus occurs due to suboptimal insulin function (insulin resistance) or decreased insulin function. Type-2 diabetes mellitus treatment is chronic and lifelong. One of the treatments is the use of insulin and oral anti-diabetic drugs. This treatment requires a long period of time and can cause unwanted side effects. Therefore, alternative treatments are needed with minimal side effects by utilizing herbal plants containing Aloin B compounds because they have been proven to be used as antidiabetic agents. These compounds can be found from the Aloe Vera plant (Aloe Vera l.). The aim of this study was to find compounds derived from Aloin B compounds that have the most potential as anti-diabetic type-2 by inhibiting the pancreatic α-amylase enzyme (code: 1B2Y) in breaking down starch in the body. The certainty of the presence of the compound Aloin B in the flesh of the aloe plant was confirmed by the LC-MS test. This research was conducted using the Quantitative Structure-Activity Relationship (QSAR) and Molecular Bonding method. The results showed that the ID S22 compound with the IUPAC name (S)-10-amino-1,2,8-trihydroxy-6- (hydroxymethyl) -10- ((2R,3R,4S,5S,6R) -2,3, 4,5-tetrahydroxy–6(hydroxymethyl) tetrahydro-2H-piran-2-yl) anthracene-9(10H)-one is the most potent compound from Aloin B derivatives as a type-2 antidiabetic agent in the mechanism of inhibiting α-enzyme action pancreatic amylase, based on the value of R2 = 0.980, the PRESS value of the compound was 0.0004, the binding energy value was -7.07 kcal/mol, the inhibition constant was 6.58 uM and the formation of hydrogen bonds between the compound and the amino acid residues aspirin, glycine, threonine and arginine.