Articles

Effect of Substituents on the Biological Activity of Isatin Hybrids – A SAR Study

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Isatin (2,3-dioxindole) is a benzopyrrole derivative that belongs to a large class of heterocyclic chemicals. Isatin derivatives are essential synthetic substrates that can be utilized as starting materials to build a wide range of heterocycles with diverse applications in pharmaceutical sciences. Isatin derivatives therefore have recently gained a lot of attention. This review emphasizes on the Schiff base derivatives from isatin, isatin quinoline/flouroquinone, isatin -thiazole, isatin–azole hybrids, all possessing potential biological activity. The structure–activity relationships of these potential leads are also discussed.

A brief review on Triazole and its Pharmacological Application

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The triazole core is one of the most imperative and well known heterocycles which is composed of nitrogen atom which forms natural products with medicinal claims. Triazole moiety is present as a principal structural component in the drug categories such as antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepressant, antioxidant, antihistaminic, antitubercular, antidiabetic etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant platforms. The elementary heterocyclic rings present in the numerous medicinal mediators are 1,2,3-triazole and 1,2,4-triazole. A huge capacity of investigations has been approved on triazole and their results, which has proved the pharmacological status of this heterocyclic core. The current paper is an try to review the pharmacological activities reported for triazole derivatives in the current literature with an apprise of current research discoveries on this nuclei.