Histological Changes in the Lung Tissue in Association with COVID-19: Review Article

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Background: It has been shown that SARS-CoV-2 is a multi-systemic virus and can affect number of body systems including the respiratory tract, the gastro-intestinal tract, the liver, the kidney and the nervous system. Despite the high mortality rate, there is little literature on postmortem findings of this unique virus, perhaps due to its highly contagious nature, inadequate information on prevention, and a lack of robust infrastructure for appropriate management of infected cases at various centers throughout the world.

Aim of the study: The aim of the current study was to review and list the main histological changes seen in patients died because of COVID-19.

Methods: A systemic search was carried out including Google Scholar, PubMed, and MEDLINE and the Google search Engine in order to scan all available published articles dealing with histological changes affection the lung in patients with documented COVID-19. The following key words were used to accomplish the search mission: COVID-19, SARS-CoV-2, Lung Histology, Pulmonary Histology, Histopathology. The search was limited to articles written in English language. Any article published between the end of 2019 and the time of initiating the current work was reviewed. The information in the current review is totally based on reviewed articles that are mentioned in the section of references.

Results: The main sources of lung tissues were Whole lung biopsy, Postmortem study, Core needle biopsy and Ultrasound based samples from autopsy. The exudative changes include injury to pneumocytes, congestion of capillaries, giant cell formations, dilation of alveolar ducts, thickening of capillaries, edema of interstitium and formation of hyaline membrane. The proliferative changes include hyperplasia of Type-2 pneumocytes with some reactive atypia with proliferation of myofibroblastic cells leading to granulation tissue formation, thickening of alveolar wall accumulation of alveolar macrophages, interstitial thickening which harbors collections of proliferating fibroblasts together with foci of hemorrhage and lymphocytic infiltration.

Conclusion: The main histopathological changes in lung of patients with COVID-19 can be grouped into three main phases, exudative, proliferative and fibrotic phases in addition to changes involving vascular tissues, bronchi and bronchioles and the main changes are the diffuse alveolar damage seen in exudative and proliferative phases.

Assessment of Nurses’ Knowledge Regarding Management of Patient’s with Cholelithiasis Disease

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Cholelithiasis affects approximately 15% of the US population. Rising trends in obesity and metabolic syndrome have contributed to an increase in diagnosis of cholelithiasis. There are several risk factors for cholelithiasis, both modifiable and non modifiable. Women are more likely to experience cholelithiasis than are men. Pregnancy, increasing parity, and obesity during pregnancy further increase the risk that a woman will develop cholelithiasis. The classic presentation of persons experiencing cholelithiasis, specifically when gallstones obstruct the common bile duct, is right upper quadrant pain of the abdomen that is often elicited upon palpation during physical examination and documented as a positive Murphy’s sign Descriptive Cross-Sectional Design is adopted in the current study to achieve the early stated objectives. The study started from January   2nd, 2021 until May, 20th, 2021.  A Non-Probability (Convenience Sample) of (60) nurses were including in the present study. Sample collect from 1, 3,4) and emergency department The results of the present study indicated that the majority of the samples (93.33%) have deficit knowledge, which agree with the results of the study showed that the reasons for lack of nurses’ knowledge regarding from the researchers’ point of view “might be related to lack of continuing educational programs or sessions about Cholelithiasis, supervision, continuous evaluation of nurses’ practice, and cooperation between multidisciplinary health care team members (nurses-physicians). Conclusions according to the present study findings, the researcher can mention the following conclusions:Most of nurses in medical units had knowledge deficit concerning management of cholelithiasis nursing management. It is found that the most of nurses are middle age group within (35-39) years old. It is concludes that the most of nurses are institute and college graduated, most of the nurses years’ experience in medical wards(1-10 years). most of the sample have participating in the sessions training in medical wards  but no related to cholelithiasis nursing management. Encouraging nurses to update their information by participating in training sessions and conference inside and outside Iraq to improve their knowledge regarding cholelithiasis nursing management which working in medical wards.

Principal’s Leadership Style Based on Path-Goal Theory: A Literature Review

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The importance of the principal’s leadership style based on the Path-Goal Theory is interesting to study, and this paper examines the principal’s leadership style based on the Path-Goal Theory in achieving educational goals in schools. There are several articles on reviews of leadership styles based on Path-Goal Theory that can be found. This review aims to find out the principal’s leadership style based on path-goal theory in achieving educational goals in schools. Based on the literature review results, we found a significant relationship between the principal’s leadership style based on Path-Goal Theory in achieving educational goals in schools, which could be seen from the increase in teacher performance and teacher job satisfaction in school administration staff. The article review results showed a significant correlation between the principal’s leadership style based on the directive, supportive, participatory, and achievement-oriented leadership style on the level of performance and job satisfaction of teachers and administrative staff in schools. This is not underestimated from the influence of the principal’s leadership style based on PathGoal Theory in directing and motivating his followers in achieving educational goals at school.

Current Aspects of Xenotransplantation in Human

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Xenotransplantation is an approach which will be able to support the increasing demand of organ donation since the organ does not need to come from humans. Up till now, xenotransplantation is still barely performed since its risk and chance of success are still not proven to be safe. One of the biggest obstacles is rejection which may lead to xenograft failure and can occur in certain types and from certain causes. However, the risk of rejection can be minimized by the process of genetic engineering and applying anti-rejection drugs in which scientists and researchers are developing so that the procedure becomes safer in the future. Although the patient who was considered as the first successful xenotransplantation in human case had died a few months after the surgery and the cause of death still remains unsolved, the field of xenotransplantation still keeps developing by researchers, medical universities, and biotechnology companies since they all agree that xenotransplantation will produce lots of advantages and will be a big step of the medical treatment field. Despite the fact that xenotransplantation is a procedure that is risky and raises public concerns and ethical issues, the procedure is still believed to give more benefits towards the patient and medical development since serious problems like organ shortage and high number of deaths on the waiting list will be solved.

Role of Aminotransferase in Patients of Type 2 Diabetes Mellitus

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Introduction: Diabetes mellitus is a heterogeneous group of disorders characterized by persistent hyperglycemia with carbohydrate, lipid, and protein metabolism resulting from defects in insulin secretion and/or insulin action.

Objectives: The main objective of the study is to find the role of aminotransferase in patients of type 2 diabetes mellitus. Methodology of the study: This cross sectional study was conducted in BVH, Bahawalpur during 2021. The data was collected from 100 patients of both genders. Patients whose fasting plasma glucose (FPG) ≥126 mg/dl on 2 occasion were included in the study. Patients with any concomitant diseases which can alter liver function and patient with hepatitis, alcoholic and taking any medicine were excluded from the study.

Results: The data was collected from 100 patients with a mean age of 53.72 ± 9.82 years old and mean duration of disease of 7.41 ± 6.01 years were included in the final analysis. There were no significant difference in the levels of Fas, AST, Cl, K, Ca, BUN, creatinine and uric acid in type II diabetics compared to the non-diabetic healthy control group.

Conclusion: Serum alanine aminotransferases are frequently high in patients of type 2 diabetes mellitus. However, there was no association with gender, body mass index, or duration of diabetes.

Surgical Treatment of Gallstones in Patients Undergoing Gastric Bypass Surgery as a Treatment of Obesity

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Introduction: Sustained weight loss after gastric bypass is achieved by a combination of gastric restriction and a variable degree of malabsortion and has therefore a greater risk for gallstone development than purely restrictive procedures like adjustable gastric banding.

Objectives: The main objective of the study is to analyse the surgical treatment of gallstones in patients undergoing gastric bypass surgery as a treatment of obesity.

Material and methods: This randomized control trial was conducted in Jinnah Hospital, Lahore during 2021 to 2022. Patients who underwent bariatric surgery for obesity were included in the study. Those who had cholecystectomy before bariatric surgery, those who underwent concomitant cholecystectomy (CC) during bariatric surgery, those with concomittant gall stoness and those who did not attend their follow-up regularly were excluded from the study.

Results: The data was collected from 100 patients and we reviewed records from all patients treated for acute biliary pancreatitis. The average age was 36.43±9.52 years and, the ratio of women/men was 151 (81.6%)/34 (18.4%). Mean BMI was determined as 44.16±5.09. When comorbidities were evaluated, 116 (62.7%) patients had comorbidity, while 69 (37.3%) patients did not. Conclusion: It is concluded that prophylactic and selective management can be safely performed and the only significant difference with patients not submitted to concomitant cholecystectomy is mostly observed in operative times that are higher in those who do undergo cholecystectomy.

Analysis of Role of Turmeric in Management of Alveolar Osteitis

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Background and objective: Alveolar osteitis created disruption in healing process after clot foration but before wound organization. The main objective of the study is to analyse the role of turmeric in management of alveolar osteitis.

Material and methods: This descriptive cross sectional study was conducted in DHQ Sargodha during Nov 2019 to Jan 2020. This study was done with the permission of ethical committee of hospital. There were 180 participants in this study. Data was collected from two study groups, one was treated with turmeric and group B was treated with Zinc oxide eugenol (Alveogel).

Results: The data was collected from 180 patients, 90 patients in each group. Group A shows symtopms of pain, swelling and halitosis from second day while Group B shows all these symptoms around day 5th. According to t-test there was a significant difference between two treatments. The significant value of p < 0.05. There was no side effect of turmeric observed in our study, so it can be used as an alternative for the management of dry socket.

Conclusion: It is concluded that there are no side-effects of turmeric. Excess use of euginol, can lead to necrosis of bone. The turmeric can be used as a medicament for the management of dry socket. Excess use of eugenol can lead to necrosis of bone.

Utilization of Nanogold and Nanosilver as Drugs Delivery on Antioxidant Activity in Herbal Medicine Preparation During Pandemic Covid-19

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The purpose of this study was to determine the effect of adding nanogold and nanosilver with various concentrations on the antioxidant activity of herbal medicine made from black seed, black garlic extract, and propolis. The concentration of nanogold used was 5,10,15,20,25 and 30 ppm with 20 ppm nanosilver concentration. In this study, the activity of antioxidant compounds was tested using the DPPH method with a UV-Vis spectrophotometer. This study shows the percentage of free radical reduction results. The results of this study indicate that there is an effect of adding nanogold in the antioxidant content of herbal medicines. The best nanogold concentration was shown at a concentration of 30 ppm, which was 84,42%. The results show that the greater the concentration of nanogold added, the greater the percent reduction.

Organochlorine Pesticide Characterisation of Emede Wetland Isoko South Delta for Pen Aquaculture in Secondary Schools as an Emerging Trend in Vocational and Technical Education in the 21st Century Nigeria

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This study is an ex-post facto research that investigated the organochlorine pesticides content of Emede wetland for its suitability for pen aquaculture in secondary school. The study answered 3 research questions and tested a hypothesis. To achieve this, the research area Emede wetland was mapped out into research cells. From each of the research cells, water samples were collected from 10 sampling spots, bulked and a composite drawn and fixed with HNO3 and stored in ice cooled boxes for laboratory analysis. The analytical standards adopted for the study were USEPA, APHA and ASTM and the analytical instrument deployed for determination of the organochlorine pesticides was EPA 8081 ECD. The mean results obtained are as follows: adrin 0.76±1.4µg/l, diedrin 1.26±0.30 µg/l, DDT 2.13±0.42 µg/l, endrin 0.62±0.55 µg/l and heptachlor 2.13±0.42 µg/l. The results obtained were subjected to test of significance with ANOVA at 0.05 level of significance deploying SPSS model 21. The p-value is 0.31 thus rejecting Ho. The study recommends that pen aquaculture should not be implemented in Emede wetland, the pollutions source should be identified and blocked and remediation should be carried out in the wetland to resuscitate the wetland to its hitherto healthy status.

Implementation of Accounting Information System and Just In Time in Increasing Employee Work Productivity

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This study aims to prove the effect of accounting information systems and Just In Time on employee productivity and the effect accounting information system on the implementation of Just In Time. The research method is descriptive quantitative with the technique of taking the sample is simple random and determining the number of samples using the Slovin formula with the number of respondents 77 people. Data collection uses a questionnaire which is distributed directly to employees at PT Distributions Bekasi who work in finance, marketing, delivery of goods, warehouse and administration. The results of the study conclude that the accounting information system and Just In Time partially have a positive and significant effect on employee productivity. likewise, the accounting information system has a positive effect on the implementation of just in time This means that the better the accounting information system and just in time will increase profits and improve the company’s position through good cost control, good delivery of goods and improving the quality of products, services and services to consumers. The results of the study have positive implications for managerial performance in controlling, planning and decision making in company operations.