The Puzzle of Mosaicism: Mechanisms and Clinical Implications in Preimplantation Genetic Testing
Chromosomal mosaicism in preimplantation embryos, characterized by cells with varying genotypes, arises due to mitotic errors after fertilization. These errors, including anaphase lag, mitotic nondisjunction, or cytokinesis failure, typically occur during early embryonic divisions when maternal factors predominantly regulate development. The impact of mosaicism on embryonic viability varies based on the stage and nature of […]
