Articles

Effect of Chemotherapy on Protein Level of Under Treatment Cancer Sufferers

/in /by

Introduction: Cancer staging is an important aspect of cancer management and directly affects the treatment plan of the patient.  There are several protein tumour markers that helps in the diagnosis as well as prognosis of cancer patients.

Aim:  The current study aims to evaluate the total protein value from the serum samples of selected cancer patients and see any pattern with different stages of patients.

Materials & Method:  Total proteins were measured by IR-VS spectroscopy method and compared in different patients.

Result:  The spectrophotometric analysis of the collected serum samples showed that chemotherapy induced total protein loss is associated with dysregulation in serum proteins and electrolytes. Total protein is a significant marker that can help determine the tumour staging in cancer patients and thus can act as a prognostic marker also.  It is a simple, non-invasive and cost effective method of analysis.

Gingival Pyogenic Granuloma -Clinical Case Report

/in /by

Pyogenic granuloma is a vascularized non neoplastic lesion, in the oral cavity, caused by trauma, local irritants or hormonal factors, with a higher prevalence in women, present more frequently in the mandible than in the maxilla. It is not associated with pus as its name suggests and histologically it resembles an angiomatous lesion rather than a granulomatous lesion. It is known by a variety of names such as Crocker and Hartzell’s disease, granuloma pyogenicum, granuloma pediculatum benignum, benign vascular tumor and during pregnancy as granuloma gravidarum Treatment consists of removal of local irritant, if any followed by excisional biopsy. This clinical case report presents the clinical and histopathological characteristics of the large pyogenic granuloma in a 36-year-old female, who reported to the Department of Santosh Dental College, Ghaziabad. Intraoral examination revealed a lesion mainly non tender, sessile, soft in consistency and measuring approximately 16by 9 mm in diameter in the posterior side of maxillary first quadrant. Keeping in view the characteristics of the lesion, anamnesis and the literature, the pyogenic granuloma and giant cell granuloma were defined as diagnostic hypotheses. Excisional biopsy was done and specimen was sent for histopathological evaluation.