Articles

Efficacy study of Curcuma longa l. and Terminalia chebula retz. against dncb-induced atopic dermatitis in mice

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Atopic dermatitis (AD) presents formidable challenges in Veterinary Dermatology due to its persistent nature and diverse clinical manifestations, including itching, redness, swelling, and skin lesions. Despite advancements in therapeutic interventions like topical corticosteroids and immunomodulatory agents, a significant portion of AD patients continue to struggle with persistent symptoms and frequent flare-ups.

This study aimed to explore the effectiveness of Curcuma longa L. (CL) and Terminalia chebula Retz. (TC) alone and in combination in alleviating AD-like symptoms. A total of 54 Swiss albino mice (6 normal; 48 DNCB-treated) were divided into nine groups. Group A served as the normal control, while Group B had AD-like symptoms induced through repeated application of 2,4-dinitrochlorobenzene (DNCB) on the ear and dorsal skin (positive control). From the 14th day onwards, Group C received standard Dexamethasone treatment at 3mg, Group D was administered Curcuma longa L. extract at 100mg, and Group E received Terminalia chebula Retz. Extract at 100mg. Groups F through H received varying concentrations (50mg, 100mg, and 200mg) of both extracts in combination, while the vehicle Carbopol was topically applied in Group I for two weeks to assess their anti-pruritic effects.

Results indicated that both Curcuma Longa and Terminalia Chebula extracts, either individually or combined, alleviated DNCB-induced AD-like symptoms, demonstrated by improvements in body weight gain, reductions in skin lesions, dermatitis scores, ear thickness, and total leukocyte count values. Histopathological analysis revealed that the combination of Curcuma Longa and Terminalia Chebula extracts at 100mg and 200mg doses reduced inflammatory cell infiltration into DNCB-induced skin lesions. Moreover, this combination also decreased the DNCB-induced elevation of Th2 cytokines interleukin (IL)-4 and Th1 cytokines IFN-γ. These findings suggest that combining Curcuma Longa and Terminalia Chebula extracts holds promise as a therapeutic approach for managing atopic dermatitis.

Plant-Based Therapies for Atopic Dermatitis Management: A Review

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Dermatological issues pose a frequent challenge for small clinical practitioners, presenting a spectrum of conditions encompassing otitis, pyoderma, anal sac problems, flea allergy, and atopic dermatitis (AD). Atopic Dermatitis (AD) is a chronic and recurring skin condition characterized by distributed skin lesions. In recent decades, researchers have shown a keen interest in AD due to its increased prevalence in developed countries. While various treatment strategies, including biological and immune modulators, are available for AD, each has certain limitations. Researchers have exhibited a significant interest in managing AD with herbal medicines. The use of herbal drugs for AD could potentially eliminate local and systemic adverse effects associated with long-term corticosteroid use, as well as reduce the high cost of therapy with biological drugs. This review discusses traditional East Asian herbal medicines as well as scientific data related to newer herbal extracts or compositions for the treatment of AD. The paper also delves into in vivo animal models and in vitro cell cultures that have been investigated with herbal medicines to establish a potential role in the treatment of AD. In conclusion, herbal medicines could serve as a better and safer complementary and alternative treatment option for AD.