Tag Archive for: Seizure

Carbamazepine is used to control and treat bipolar 1 disorder’s acute manic and mixed episodes, trigeminal neuralgia, and epilepsy. Generalized tonic seizures (grand mal), mixed seizure patterns, and partial seizures with complicated sympatomatology (psychomotor, temporal lobe) are the only indications for epilepsy. Trigeminal neuralgia or tic douloureux are first-line conditions for which carbamazepine is FDA-recommended. In individuals with acute manic or mixed episodes of bipolar 1 mania, a comprehensive evaluation demonstrates the effectiveness of carbamazepine extended release. Carbamazepine is contraindicated in patients with bone marrow depression and hypersensitivity to this drug or tricyclic compounds such as amitriptyline. Dizziness, sleepiness, ataxia, nausea, and vomiting are some of the most typical adverse effects of carbamazepine. With the ability to penetrate the placenta and pass through breast milk in nursing infants, carbamazepine necessitates a choice between stopping the medication in the mother or stopping nursing. Different analytical techniques developed and validated as per ICH guidelines for the determination of carbamazepine, including High performance liquid chromatography (HPLC), Ultra performance liquid chromatography (UPLC), mass spectrometric, Liquid chromatography-Mass spectroscopy (LC-MS), and UV-Spectrophotometry has been explained in this article as it is important to analyze the drug content and % purity  in bulk and Pharmaceutical formulations for quality control purpose.