Articles

Characterization to Estimate the Size of Gold Nanoparticles Deposited in Pregnancy Tests Using Diffuse Reflectance Spectroscopy

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When using a pregnancy test, a urine sample is deposited in one side of the nitrocellulose strip, which moves by capillary action to the other side of the test, where there are immobilized particles or biomarkers that indicate a positive or negative test result. Based on the manufacturer’s data sheet, these are usually colloidal gold nanoparticles. This paper describes the results of a characterization study using diffuse reflectance spectroscopy on qualitative pregnancy tests. The importance of this study resides in the possibility of finding invalid tests or false negatives in the results, at the same time, the approximate size of the nanoparticles can be determined indirectly by analysing the spectra obtained experimentally.

A Green approach of Ag and Au Nanoparticles, Properties and its Applications: A Review

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The emergence of nanotechnology has transformed antimicrobial and cancer treatment methodologies employed by clinicians. Conventional approaches, such as, radiotherapy, hormonal therapy and chemotherapy, now have a contemporary counterpart in nano therapy, presenting a potential alternative. This innovative treatment paradigm holds promise due to its minimal side effects in comparison to traditional methods. Notably, metallic nanoparticles synthesized through green chemistry utilizing biological entities, contribute to the mitigation of side effects while augmenting the metal’s efficiency against cancer cells. These environmentally friendly nanoparticles have become integral in research, demonstrating significant antimicrobial and cytotoxicity activities across diverse cancer cell lines. In this review concentrates on metal nanoparticles, specially silver and gold, synthesized via green chemistry approach. The aim is to explore their impact on inducing cancer cell death, delving into the associated molecular pathways. The primary objective of this review is to discern strategies for expediting the clinical applications of silver and gold nanoparticles based therapeutic systems. The overarching goal is to reduce normal tissue toxicity consequently elevating the overall efficacy of the treatment. Anticipated advancement in nano-medicines are poised to revolutionize future cancer treatment modalities, ushering in a paradigm shift characterized by minimal side effects and enhanced therapeutic outcomes.