Articles

Analysis of Risk Factors for Death in COVID-19 Patients at Bahteramas Regional General Hospital, Southeast Sulawesi Province

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Background: Coronavirus disease 2019, or COVID-19, is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 has been classified as a pandemic since 2020.

Purpose:  The purpose of this study was to determine the risk factors for death due to COVID-19 at the Bahteramas Public Hospital, Southeast Sulawesi Province.

Method: This research is a retrospective analytic study with a cross sectional approach. The number of samples is 85 samples. The sampling technique was purposive sampling. The data were processed using the Chi-Square test and Odds Ratio.

Results: This study shows that 47 people died at the Bahteramas Hospital in Southeast Sulawesi Province from March to November 2020, the variable age (p value = 0.001 and OR value 5.216), gender (p value = 0.078 and OR value = 2.180), hypertension variable (p value = 0.071 and OR value = 2.510), and diabetes mellitus variable (p value = 0.013 and OR value = 3.300).

Conclusion: Age, sex, hypertension, and diabetes mellitus are risk factors for death due to COVID-19 at Bahteramas Public Hospital, Southeast Sulawesi Province.

 

Diabetes Leading to Kidney Disease: A Review

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia, and it represents a significant risk factor for the development and            progression  of  kidney disease. This review aims to elucidate the complex interplay between diabetes and kidney disease,  highlighting  the underlying  mechanisms, risk  factors, diagnostic  approaches,  and therapeutic interventions.

Study to Assess the Prevalence of Risk Factor of Chronic Kidney Disease among Diabetes Mellitus and Hypertensive Client at Karambakkam

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Aim: The present study aims to assess the prevalence of risk factor of chronic kidney disease among diabetes mellitus and hypertensive client at karambakkam.

Methods and Materials: A Non-experimental descriptive research design was used for the present study. A total 200 samples were collected using purposive sampling technique. The demographic of diabetes mellitus and level of knowledge of risk factor of chronic kidney diseases was assessed using structured questioner and, followed by that data was gathered and analyzed.

Results: The results the study revealed that there is a significant association with the level of knowledge on risk factor of chronic kidney diseases among diabetes mellitus and hypertensive client at p<0.001.

Conclusion: Thus, the present study concluded that majority of the clients with diabetes mellitus and hypertension had inadequate knowledge and it is recommended that they should be educated on the risk factors of CKD.

Anti-Diabetic Agents in Covid-19, Their Possible Role Beyond Diabetes

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Recent reports from various observational investigations revealed and published the outcomes of Non-insulin Anti-diabetic agents. Patients additionally with Type-II Diabetes Mellitus and coronavirus disease, caused by severe acute respiratory syndrome [SARS] has become widespread disease in the world since last 3 years. Age, sex, ethnicity, obesity and co-morbidities all apparently enhance the risk of worst consequences. Glucose lowering drugs and anti-viral drug treatment could limit the risk but impose restrictions on their usage which needs to be carefully assessed. This severe acute respiratory syndrome [coronavirus] might be a potentially triggering and worsen the aspect for the diabetic patients that can bring about severe metabolic complications effecting β-cell function leading to hyperglycaemia and diabetic ketoacidosis.

Analysis of Characteristics of Coronary Artery Stenosis Based on the Comorbidities in Coronary Heart Disease Patients Undergoing Coronary Angiography

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Background: Comorbid diseases are a risk factor for atherosclerosis in coronary heart disease (CHD). Atherosclerosis causes the narrowing of the coronary arteries so that the heart muscles lack blood supply. Diagnostic coronary angiography is an invasive medical examination performed to determine the presence of coronary artery stenosis and to show the location and the number of coronary artery stenosis.

Objective: This study aimed to analyze the characteristics of coronary artery stenosis based on comorbidities of patients with CHD undergoing coronary angiography.

Methods: This analytical study was conducted using a cross-sectional design of 105 patients with CHD undergoing coronary angiographyat the catheterization laboratory at Bahteramas Hospital, Southeast Sulawesi, from January 1 to December 31, 2021.Statistical testing used Chi-squaretests with 95% confidence interval and significance set as p<0.05.

Results: Most of the respondents were over 45 years old as many as 87 (82.9%), and most are male as many as 72 (68.6%). The category of the highest number of stenosis was less than two stenosis, namely 70 patients (66.7%) with the most common location as the  Left Anterior Descending. The comorbidities category included a history of dyslipidemia in 41 people (39.0%), history of diabetes mellitus (DM) in 28 people (26.7%), and history of hypertension in 75 people (71.4%).The bivariate analysis showed a history of DM was associated with coronary artery stenosis (p-value = 0.007) with an Odds Ratio of 3.111.

Conclusions: Patients with DM have 3.111 times greater possibility of developing stenosis of the coronary arteries.WC:246

Genetic Predictors of Development of Diabetic Foot Syndrome in Patients with Diabetes Mellitus

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An increase in the population of patients with diabetes mellitus affects the incidence of diabetic foot syndrome (DFS), as its chronic complication. Among the various types of growth factors that play a role in the development of late complications of diabetes, vascular endothelial growth factor, VEGF, is currently in the focus of attention. The study conducted by the authors was aimed at determining the relationship between the G634C polymorphism of the VEGFA rs2010963 gene and the predisposition to the development of diabetic foot syndrome in patients with diabetes mellitus. We examined 96 patients aged 39 to 76 years with diabetes mellitus complicated by diabetic foot syndrome. Based on the studies, it was determined that the G634C polymorphism in the VEGFA gene (rs2010963) is involved in the formation and development of diabetic foot syndrome in patients with diabetes mellitus.

Descriptive Study to Assess the Knowledge Regarding Self Administration of Insulin Injections

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Introduction: Diabetes mellitus usually called  diabetes sugar condition that occurs  when the ones body does not produce insulin or body is enable to use normal amount insulin properly.

Objectives: The objectives of the study where on asses the knowledge and practice regarding the diabetes patient.

Design: a descriptive survey approach to assess the knowledge regarding self administration of insulin among the diabetes mellitus patient.

Tool: using 15 items questionnaire was in known portability conversing sampling technique the sample setting is selected area of kansarakui.

Sample Size: the sample size was 40.

Result: The study identify the 17 patient (42.55) having good, 16(40%) have average, and (17.5) poor knowledge administration of insulin among diabetes patient.

The Use of Moringa Oleifera Powder to Prevent Pancreatic Organ Cell Damage in Pregnant Mice with Diabetes Mellitus

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Introduction: Diseases that accompany pregnancy, such as diabetes mellitus, affect preeclampsia. This disease is a hereditary disorder characterized by reduced circulating insulin, high blood sugar concentrations, and reduced glycogenesis. This study tried to determine the effect of giving Moringa leaf powder (Moringa oleifera) in preventing pancreatic organ cell damage in pregnant rats with diabetes mellitus.
Method: A total of 30 pregnant white rats, which were divided into 6 groups, were examined for their sugar levels on day 4 after being induced by alloxan for 18 days to ensure that they were already in a hyperglycemic state.
Result: The results showed that the administration of Moringa leaf powder at a dose of 800 mg/day/kg BW could reduce pancreatic cell apoptosis, approaching the negative control group.
Conclusion: In conclusion, the moringa leaf powder is able to improve the clinical pathological condition of pregnancy, due to inhibition of apoptosis and repair of pancreatic Langerhans cells.

The Effect of Nanogold-Nanosilver to Boost Immunity of People Affected by COVID-19 with Comorbidities of Diabetes Mellitus

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COVID-19 virus has spread almost all over the world, including Indonesia until now. COVID-19 in people with diabetes mellitus have a risk of exacerbating symptoms. Diabetes is a disease caused by high blood sugar levels. Nanogold has a very strong anti-oxidant capability, while nanosilver has anti-bacterial properties. In this research, nanogold-nanosilver was presented in the form of health drinking water packaged in 1 L bottles and could be consumed directly. This research aimed to determine the effect of nanogold-nanosilver to boost the immunity of people affected by COVID-19 with comorbidities of diabetes mellitus on Jl. Merr Surabaya to Juanda highway, Surabaya City. The method in this research was the lecture method at the beginning of the activity. Health Drinking Water Materials were distributed once a week, namely on Friday, July 31 to August 28, 2020. The sampling technique used accidental sampling with a total sample of 100. Interviews recording medical conditions were collected and analysed. The results obtained were a decrease in blood sugar levels to normal in patients with diabetes mellitus and the immunity of the participant volunteers was well maintained in the midst of the COVID-19 pandemic. The age group under 39 years had the greatest decrease in blood sugar levels. In accordance with the research results, Nanogold-Nanosilver Health Drinking Water has succeeded in increasing and maintaining the immunity of participants who have comorbidities with diabetes mellitus and are affected by COVID-19. Besides, the participant survived not to be affected to COVID-19 during activities.

Prevalence of Coronary Heart Disease (CHD) and Selected Risk Factors of CHD, Among People Aged 30-64 Years in the District of Gampaha, Sri Lanka

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Background- Coronary heart disease (CHD) is the leading cause of hospital deaths in Sri Lanka. The underlying risk factors include; tobacco smoking, unhealthy diet, harmful alcohol use, physical inactivity, and medical conditions; hypertension, diabetes mellitus, obesity, dyslipidaemia. Objective of this study was to determine prevalence of CHD and risk factors among people aged 30-64 in Gampaha District, Sri Lanka.
Methods- A community based cross-sectional study was conducted among 1192 people aged 30-64 years in district of Gampaha, recruited by probability proportionate to the population size, cluster sampling. Data were collected using a pre-tested interviewer-administered questionnaire on prevalence of CHD, hypertension, diabetes mellitus, dyslipidaemia, obesity, harmful alcohol use, unhealthy diet, physical inactivity and tobacco smoking and anthropometric measurements by trained data collectors. Twelve-lead ECG, blood pressure, fasting plasma glucose and lipid levels were done for previously undiagnosed. Data were analyzed using SPSS-21.
Results- The estimated prevalence of CHD based on already diagnosed cases and Rose positive angina 6.9% (95% CI 5.4% – 8.4%), CHD based on already diagnosed cases and ECG 6.4 (95% CI 4.9% – 7.8%), hypertension 37.5% (95% CI 34.7% to 40.3%), diabetes mellitus 17.4% (95% CI 15.2% to 19.6%), dyslipidaemia 66.5% (95% CI 63.8% – 69.2%). The estimated prevalence of other modifiable risk factors of generalized obesity (BMI≥25.0) (44.0%, 95%CI41.1-46.9), sub-optimal quality diet (71.9%, 95%CI 69.3-74.5), low level of physical activity (21.7%, 95%CI 19.3-24.1), heavy or high-risk drinking 11.4% (95%CI 9.56-13.2), smoking 14.2% (95%CI 12.2-16.2).
Conclusions- Estimated prevalence of CHD and selected risk factors were high in Gampaha District with a large proportion of previously undiagnosed disease. Immediate public health action is needed including training programs for healthcare workers on detection of risk factors and awareness among the public for screening for risk factors.