Association of Adiponectin Levels with Polycystic Ovarian Syndrome

Objective: To measure the levels of adiponectin in women with PCOS having high body mass index.

Methodology: A cross-sectional study including 96 study participants was conducted in Services Hospital, Lahore in December 2020 out of 96 study participants 48 were enrolled as cases having polycystic ovarian syndrome compared with 48 healthy women as controls. Detailed information about age, duration of menstrual cycle, body mass index (BMI), and clinical features like obesity, infertility, acne and hairs on face were noted. A total 5ml venous blood was collected by using aseptic techniques and then centrifuged immediately; serum was separated and stored at -20 °C after proper labeling.  Samples were analyzed for estimation of serum adiponectin by using enzyme linked immunosorbent assay. Statistical analysis was carried out by statistical package for social sciences (SPSS) 21. The p-value < 0.05 was considered to be statistically significant.

Results: In this study level of adiponectin was decreased in PCOS women as compared to healthy women. Mean ± SD of adiponectin in PCOS women was 2.08±0.70µg/ml which was lower than in control group 9.71±5.35µg/ml. Median/Inter Quaitel Range of PCOS women was 2.00/0.78 which is lower in comparison with the Median/IQR of adiponectin in healthy women 8.60/9.63, p-value of   adiponectin was significant (p = 0.00).

Conclusion: Adiponectin is important variable present in circulation. Its levels are changed in response to disease process as occurs in PCOS.