Analysis of The Relationship Between Compliance in Taking Pulmonary Tuberculosis Medication in East Kolaka District

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Tuberculosis is still a global health problem today. 5.8 million in 2020 and 6.4 million in 2021. The number of 2022 is a large number of people suffering from TB in the previous year. people diagnosed with TB in the world as many as 7.5 million people in 2022. This study is to analyze the relationship between adherence to taking pulmonary tuberculosis medication in East Kolaka Regency. This study was conducted in six working areas of the East Kolaka Regency Health Service, namely at the Tirawuta Health Center, Tinondo Health Center, Lalolae Health Center, Mowewe Health Center, Sanggona Health Center, and Ueesi Health Center in May – June 2024. This type of research is a study using a Cross Sectional Study approach with univariate, Bivariate, and Multivariate analysis. the population is 59 patients spread across six working areas of the East Kolaka Regency Health Service. Chi-Square Test Results of knowledge (P-Value 0.004<0.05), Family Support (P-Value 0.000<0.05), Role of Health Workers (P-Value 0.325), Stigma (P-Value 0.008<0.05), Access (P-Value-0.000<0.05), Income (P-Value-0.002<0.05), Medical Costs (P-Value0.003<0.05). The dominant variable is related to Access to Health Facilities with an OR value of 22.818. Access to health facilities is the main point in obtaining optimal health services. Compliance with taking tuberculosis medication is the basis for the success and completion of tuberculosis disease, it is expected that related parties will provide more emphasis on the consequences of non-compliance with taking tuberculosis medication.

The Development of Problem Based Learning Materials to Improve Students’ Logical Mathematical Intelligence on SPLTV

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The research was conducted with the aim of developing valid, practical, and effective PBL learning materials for SPLTV subjects. The development of learning materials aims to improve students’ logical mathematical intelligence. This research is a type of development research with the 4D Thiagarajan model with the stages of define, design, develop, and disseminate. The learning materials produced include teaching modules, students worksheet, learning videos, test packages, and instruction manuals for using learning materials. Data collection was carried out using observation, questionnaire, and test methods. The results of the study showed that the learning materials developed were valid, practical, and effective. The level of validity can be seen from the validity value of each tool as follows, teaching modules of 3,79, students worksheet of 3,82, test packages 3,86, and instruction manuals 3,75. The level of practicality can be seen from the results of observations of the implementation of learning materials with an average of 3,43. The level of effectiveness of the materials can be seen from the results of student learning completion with a classical completion percentage of 84,6%, the N-Gain category is high with a student percentage of 97,29%, students’ logical mathematical intelligence activities are in the good category with a percentage of 84,33%, and the percentage value of student responses is 92,05% with a positive response.

Biosynthesis of Ag-nanoparticles from North Central Nigerian Propolis Extract as Highly Efficient Anticorrosion Additive of Carbon Steel in Acidic Medium

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Metals in use begin to corrode as soon as they come in contact with a hostile environment. This drastically reduces the useful life of metallic materials, affecting home and industrial properties. In addition to the high cost of production, inorganic corrosion inhibitors are known to be harmful to the ecosystem, thus the need for low-cost, efficient, and environmentally friendly alternatives. Due to their high surface-to-volume ratio and capacity to create self-assembled films on metal surfaces, benign nanoparticles present a good alternative. In this study, North Central Nigerian propolis Extracts (NCNPE) were utilized to synthesize silver nanoparticles and were characterized spectroscopically. The North Central Nigerian propolis Extracts-Silver Nanoparticles composites (NCNPE -AgNPs) were then tested for corrosion-inhibitive potentials in HCl solution. The surface plasmon resonance (SPR) absorption bands were obtained at around 422 nm. The XRD results showed that the resultant crystalline NCNPE -AgNPs has FCC structure, with a mean nanoparticle size of 1.36128 ± 0.04962. The STEM image revealed several oval structures that were densely filled with AgNPs, which appeared as white spots, with patterns that appeared homogeneous. In the presence of 1000 ppm NCNPE -AgNPs, the results showed high inhibition efficiency of 86.49 and 96.44 % for EIS and gravimetric technique, respectively. Also, the thermodynamic and adsorption characteristics of NCNPE -AgNPs on CS in HCl solution were calculated. It was discovered that the NCNPE -AgNPs performed well as an inhibitor of CS corrosion in HCl.

The Addition of Lauric Acid from DPKFA (Distilled Palm Kernel Fatty Acid) as A Feed Additive on The Physiological Responses of Broiler

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The aim of the research is to examine the effect of adding additive products to feed on the physiological responses of broilers during 1 (one) rearing period including rectal temperature, shank temperature, comb temperature, respiratory frequency and heart rate frequency. The research was conducted from September 21 to October 26, 2024 in Mr. Soleh’s Farm. Kidal Village, Tumpang District, Malang Regency, East Java. The material used in this study was non-sexing DOC (Day Old Chick) strain Lohmann from PT Japfa Comfeed Tbk. A total of 300 broilers with a body weight diversity coefficient of less than 10% were reared for 35 days. This study used 6 treatment groups, each consisting of 5 replicates including T0 (Basal feed as control treatment), T1 (Basal feed + zinc bacitracin 0.1% as positive control treatment), T2 (Basal feed + 0.05% feed additive product), T3 (Basal feed + 0.10% feed additive product), T4 (Basal feed + 0.15% feed additive product) and T5 (Basal feed + 0.20% feed additive product). The data obtained were analyzed using analysis of variance (ANOVA) and continued with Duncan’s Multiple Range Test (DMRT) if there was a significant effect. The results showed that the addition of DPKFA-based feed additive products with high lauric acid content in the feed did not significantly affect the physiological response of broilers (P>0.05). The provision of additives with the highest concentration helps to optimize the physiological response of broilers so that this product can be recommended as a substitute for the role of AGP to support the performance of broiler production and health.

The Impact of Audited Financial Statement Announcements on Stock Returns and Liquidity: Evidence from LQ45 Companies in Indonesia

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This study examines the impact of Audited Financial Statement Announcements on Stock Return and Stock Liquidity in companies listed in the LQ45 index on the Indonesia Stock Exchange during the 2021-2023 period. Using a quantitative approach, this research analyzes time-series data over an 11-day event window (five days before, the announcement day, and five days after). A total of 33 companies were selected through purposive sampling based on specific criteria. Stock liquidity is measured using trading volume activity and bid-ask spread, while data analysis was conducted using descriptive statistics and paired sample t-tests. The findings indicate that (1) audited financial statement announcements significantly affect stock liquidity-both trading volume and bid-ask spread-in the short term; (2) there is no significant impact on stock returns across all event periods; and (3) overall, the market responds more strongly in terms of liquidity than price movement, suggesting that audited financial reports serve as relevant signals for investor behavior, particularly in emerging markets.

Efficacy study of Curcuma longa l. and Terminalia chebula retz. against dncb-induced atopic dermatitis in mice

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Atopic dermatitis (AD) presents formidable challenges in Veterinary Dermatology due to its persistent nature and diverse clinical manifestations, including itching, redness, swelling, and skin lesions. Despite advancements in therapeutic interventions like topical corticosteroids and immunomodulatory agents, a significant portion of AD patients continue to struggle with persistent symptoms and frequent flare-ups.

This study aimed to explore the effectiveness of Curcuma longa L. (CL) and Terminalia chebula Retz. (TC) alone and in combination in alleviating AD-like symptoms. A total of 54 Swiss albino mice (6 normal; 48 DNCB-treated) were divided into nine groups. Group A served as the normal control, while Group B had AD-like symptoms induced through repeated application of 2,4-dinitrochlorobenzene (DNCB) on the ear and dorsal skin (positive control). From the 14th day onwards, Group C received standard Dexamethasone treatment at 3mg, Group D was administered Curcuma longa L. extract at 100mg, and Group E received Terminalia chebula Retz. Extract at 100mg. Groups F through H received varying concentrations (50mg, 100mg, and 200mg) of both extracts in combination, while the vehicle Carbopol was topically applied in Group I for two weeks to assess their anti-pruritic effects.

Results indicated that both Curcuma Longa and Terminalia Chebula extracts, either individually or combined, alleviated DNCB-induced AD-like symptoms, demonstrated by improvements in body weight gain, reductions in skin lesions, dermatitis scores, ear thickness, and total leukocyte count values. Histopathological analysis revealed that the combination of Curcuma Longa and Terminalia Chebula extracts at 100mg and 200mg doses reduced inflammatory cell infiltration into DNCB-induced skin lesions. Moreover, this combination also decreased the DNCB-induced elevation of Th2 cytokines interleukin (IL)-4 and Th1 cytokines IFN-γ. These findings suggest that combining Curcuma Longa and Terminalia Chebula extracts holds promise as a therapeutic approach for managing atopic dermatitis.