Design and Optimizing of Metformin and 5-Fluorouracil Co-Loaded Nano Spheres by Box-Behnken Experimental Design for the Treatment of Colorectal Cancer

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Aim and objective of the study was to design and optimize metformin and 5-Fluorouracil drug molecules co-loaded with chitosan biodegradable polymer Nano-spheres for effectively targeting colorectal cancer cells in chemically induced colorectal cancer models. The metformin and 5- fluorouracil loaded chitosan nanoparticles were formulated by ionotropic crosslinking method. Experimental design consisted of three independent variables: chitosan, tripolyphosphate and stirring speed and three dependent variables: particle size, entrapment efficiency and drug release using Box-Behnken experimental design. Response surface modelling and the ability to fit to the model were evaluated with Design-Expert® software (Version 12). The optimized formulation by the design software indicated 1.33% of chitosan, 0.715 % of TPP at a Stirring speed of 3383 rpm is recommend to achieve a desirability value of 0.813 to have an acceptable range of 0.8 to 1, suggesting that the formulation quality is acceptable and excellent.

Proposed Marketing Strategy to Increase Brand Loyalty: Study Case of Lazada Indonesia

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The Indonesian e-commerce market is poised for significant growth, with projections indicating an expansion from USD 52.93 billion in 2023 to USD 86.81 billion by 2028. This rapid growth is driven by increasing internet and smartphone penetration, coupled with a rising demand for online shopping. Lazada Indonesia, one of the major players in this market, faces intense competition from platforms like Tokopedia and Shopee. This study aims to explore the strategic positioning of Lazada Indonesia, focusing on brand loyalty and market share dynamics within the Indonesian e-commerce landscape.

Utilizing a mixed-method approach, the research integrates both qualitative and quantitative data to provide a comprehensive analysis. The study employs various strategic frameworks, including PESTLE, Porter’s Five Forces, VRIO, STP, and the 7Ps of marketing, to assess Lazada’s internal and external environments. Key findings indicate that Lazada’s strengths lie in its robust technological infrastructure, extensive product offerings, and strong brand recognition supported by Alibaba. However, the company faces significant challenges, including inconsistent user experiences, internal coordination issues, and the need for more localized marketing strategies to effectively engage with the diverse Indonesian market.

The research provides actionable insights and strategic recommendations for Lazada Indonesia to enhance its market positioning and increase brand loyalty. Strategies include improving customer service, leveraging big data for personalized marketing, and forming strategic partnerships to enhance logistical capabilities. By addressing these areas, Lazada can better meet customer needs, strengthen its competitive edge, and achieve sustainable growth in the rapidly evolving Indonesian e-commerce sector.

Marketing Strategy for a Premium Service Office Provider in a Competitive Market in Jakarta. Case Study: The Executive Centre

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The rise of remote work, the gig economy, and the demand for flexible workspaces have significantly impacted the traditional office market, necessitating innovative marketing strategies. This study aims to explore the marketing strategy of premium serviced office providers, focusing on The Executive Centre in Jakarta’s Central Business District (CBD). The research investigates key factors influencing business decisions and customer preferences, providing a comprehensive marketing analysis framework.

The study employs market segmentation, competitive analysis, and SWOT analysis to develop targeted marketing strategies. Key findings suggest that strategic location, transparent pricing, and flexible lease terms are critical in attracting and retaining clients. Recommendations include leveraging digital marketing, forming partnerships with property agents, and addressing the evolving needs of multinational companies and modern workers.

The study also examines the literature on marketing strategies, applying the most recent techniques used by various companies. By incorporating a robust theoretical framework, this research aims to provide insights and perspectives for building the most effective marketing plan. The goal is to enhance The Executive Centre’s market positioning and contribute to meeting future challenges through strategic marketing activities.

Quality Control and Quality Assurance of The BPK’s Audit of Regional Government Financial Statements Fiscal Year 2022 (Case Study at AKN VI)

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The Audit Board of the Republic of Indonesia (BPK) is a state institution mandated to audit management and accountability of state finances. One of the objects of Audit’s BPK is the Financial Statements of Regional Government (LKPD). Directorate General of Audit VI (AKN VI) BPK conducts an audit of the LKPD. In 2023, AKN VI has conducted an audit of the LKPD for Fiscal Year 2022. The audit is carried out by the BPK Regional Offices (Work Unit under AKN VI) which is located in each province in eastern Indonesia. To guarantee state financial audits’ quality in this case the audit of LKPD, BPK carries out quality control and assurance. The purpose of this study is ascertain how the process of quality control and assurance of the audits produced by BPK Regional Offices in AKN VI. A qualitative method was taken in this research to explain the process of quality assurance and quality control the results of the review in the form of suggestions submitted by the AKN VI reviewer on the LKPD audit results. The result is that quality control and assurance are established and implemented by BPK for the results of the audit, and with quality assurance in the form of a review of LKPD audit opinion by AKN VI, it can provide suggestions for improvement to keep up the quality of LKPD audit results.

An Exploratory Data Analysis (EDA) Approach for Analyzing Financial Statements in Pharmaceutical Companies Using Machine Learning

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This research investigates the use of Exploratory Data Analysis (EDA) and machine learning techniques to analyze financial statements (FSs) of pharmaceutical companies. The study focuses on three major Indonesian pharmaceutical companies: Kimia Farma, Kalbe Farma, and IndoFarma. By leveraging EDA, this study aims to uncover hidden patterns and insights within financial data, such as earnings per share (EPS), return on capital employed (ROCE), net profit margin, and inventory turnover ratio. Additionally, the study employs machine learning models, including Linear Regression, K-Nearest Neighbor (KNN), Support Vector Machine (SVM), and Decision Tree, to predict financial performance metrics and trends. The performance of these models is evaluated using metrics such as Root Mean Squared Error (RMSE), Mean Squared Error (MSE), Mean Absolute Error (MAE), and Mean Absolute Percentage Error (MAPE). Among the models tested, the Decision Tree model demonstrated the highest performance, indicating high accuracy and a strong fit to the data. These results highlight the potential of data-driven approaches in improving the operational efficiency and financial stability of healthcare organizations.

Strengthening BNI’s Position as Transactional Bank by Optimization of Cash Management Solutions

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The cash management industry is becoming significantly intense from both banking and non-banking institutions as they keep innovating and offering advanced solutions to meet and cater to the dynamic business of the customers. This study was conducted to explore the strategic initiatives that can be formulated for PT. Bank Negara Indonesia (BNI) to strengthen its position as a transactional bank through the optimization of its cash management solutions, specifically focusing on BNIDirect. The analysis was carried out by understanding the nature of the competition and assessing the position of BNI in terms of cash management solutions relative to its competitors. The study used a qualitative method based on the interview with the key executive management and the literature review related to marketing and business strategy to uncover valuable insight and best practices that can strengthen the positions of BNI as a transactional bank. The research concludes that by addressing and overcoming the challenges that impacted cash management solutions, BNI can solidify its market position and achieve sustainable growth in the competitive cash management industry.

Influence of Leverage, Profitability, and Price Share to Return Share in Manufacturing Companies on the IDX with Company Value as Intervening Variables

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There is fluctuation stock return value company manufacturers listed on the Indonesian Stock Exchange (BEI) from 2015 to 2019. Research​ This aim For test And analyze impact from various factor like Price Shares, Leverage, Profitability, and Company Value on Stock Returns. Study This use method descriptive quantitative. Sample study This is 18 reports finance company manufacturers listed on the IDX on in 2023. Data collection was carried out through reporting finance companies the. Data analysis was carried out use application SmartPLS. Results study showing that only Profitability and Price Share yuang can increase stock returns something company manufacturing on the Indonesian Stock Exchange. Company Values too proven No can mediate influence between variable study.

Analysis of Turnover Intention in terms of Job Satisfaction, Job Stress, and Social Work Environment PT XYZ

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This study aims to examine the contributions of job satisfaction, work stress, and social work environment towards employee turnover intentions at PT XYZ in Justus Area. The research method employed is quantitative, utilizing    questionnaires for data collection. This research is of the descriptive analysis type, depicting the existing characteristic phenomena. The sampling technique used is a saturated sample, meaning the entire population was sampled, totaling 62 employees    of PT XYZ in Justus Area. Multiple linear regression analysis was utilized. The findings indicate that job satisfaction has a positive and significant partial contribution towards turnover intentions, work stress has a positive and significant partial contribution towards turnover intentions, and the social work environment has a negative and significant partial contribution towards turnover intentions. Collectively, job satisfaction, work stress, and the social work environment significantly contribute to the turnover intentions of employees at PT XYZ.

Analysis of Debt Structure and Liquidity on Company Performance with Firm Size as a Moderation Variable: Sub-Sector Food and Beverage Listed on the IDX in the Period 2018-2022

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This research aims to analyze and know the influence of Short-Term Debt, Long Term Debt, Total Debt to Assets, Total Debt to Equity, and Liquidity on Company Performance with Company Size as a moderating variable on manufacturing companies of the consumer goods industry listed in the Indonesia Stock Exchange 2018-2022 period. The population of this research is manufacturing companies in the consumer goods industry sector, which consists of 47 companies. The sampling selection is conducted using the purposive sampling method. Therefore, 38 samples are obtained. The data analysis method in this research was carried out using panel data testing and data processing using the EViews program. The results of this research showed that partially and simultaneously, Short-Term Debt (STD), Long-Term Debt (LTD), and Total Debt to Assets (TDTA) have a significant effect on Company Performance. Firm Size can moderate the impact of Short-Term Debt, Long-Term Debt, Total Debt to Asset, Total Debt to Equity, and Liquidity on Company Performance.

Talent Management Strategies in Indonesia’s Digital Media and Entertainment Industry for Gen Z: The Role of Leadership Style and Organizational Culture

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This study found that leadership style has a significant effect on talent management, with transformational leadership being more effective in retaining talent in the digital media and entertainment industry. However, the use of organizational culture as an intervening variable showed no significant effect on talent management. The study also highlights the challenges and opportunities in retaining Generation Z talent in the media and entertainment sector, emphasizing the importance of factors such as diversity, inclusion, technology, sustainability, and legal considerations in attracting and retaining top talent.The survey results show that different industries have different preferences regarding leadership styles, talent management strategies, and organizational culture. The music industry values community, the gaming industry prefers transformational leadership styles, the film industry emphasizes individual recognition, and the digital marketing industry prioritizes financial rewards. The analysis suggests that leadership style has a positive effect on organizational culture and talent management, and organizational culture also affects talent management. Validity and reliability tests confirmed the accuracy of the survey data.