The Influence of Coordination and Leadership Quality on Work Discipline of Employees in the Department of Food Security, Agriculture, and Fisheries in South Barito Regency

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This study aims to examine the effect of coordination and leadership quality on work discipline of emmployees in the Department of Food Security, Agriculture, and Fisheries in South Barito Regency. The population in this study consists of all employees of the Food Security, Agriculture, and Fisheries Department of South Barito Regency, totaling 315 individuals. As the population in this study is more than 100 individuals, a random sampling method is employed based on the Slovin formula to streamline the time and cost of the research. Data were analyzed using Multiple Regression Analysis. The results of this study are Coordination has an effect on Work Discipline of employees, Leadership quality has an effect on work discipline of employee in the Department of Food Security, Agriculture, and Fisheries in South Barito Regency.

Analysis of Digital Transformation on Consumer Behavior for Shopping in Offline and Online Store (Case Study: UNIQLO Indonesia)

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Uniqlo is one of the world’s largest Apparel Fashion firms. Uniqlo’s business strategy integrates the entire clothing-making process, from planning and design to production, distribution, and retail. Uniqlo expanded its retail operations in Indonesia on February 13, 2013, and presently has 65 stores in 25 cities throughout the country. Uniqlo Indonesia must face obstacles in this digital era shift; during the COVID-19 pandemic, the rate of business owners creating e-commerce stores and customers purchasing online surged rapidly. Uniqlo has the lowest online sales contribution rate among its competitors, with 16% Online Sales Contribution and 84% Offline Sales Contribution. Uniqlo aspires to boost its online sales contribution to 20%. This study offers a maximized omnichannel integration approach between Uniqlo Indonesia’s online store and Uniqlo Indonesia’s offline stores to achieve Uniqlo’s aim of becoming the number one global apparel company. This research includes an internal analysis that includes value chain analysis and resources analysis to evaluate Uniqlo Indonesia’s internal condition and determine strengths and weaknesses, an external analysis that includes general environment analysis, industry analysis, and competitor analysis to evaluate Uniqlo Indonesia’s external conditions and determine threats and opportunities, and a customer journey analysis that includes the five A’s. Following the analytical phase, TOWS Matrix, Business Model Canvas, and Value Proposition Canvas were produced to help improve the formulation of the solution for Uniqlo Indonesia. Uniqlo Indonesia should improve every touchpoint across all integrated channels in the customer journey using Uniqlo Indonesia resources to improve the omnichannel integration strategy. This research’s business strategy and solutions can be utilized by Uniqlo Indonesia to boost customer awareness, sales, and customer loyalty.

Analysis of The Influence of Brand Awareness, Brand Image and Price on Purchasing Decisions for Samase Products in Jakarta

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The demand for Muslim clothing is increasing rapidly. This is happening because of the increasing population of Muslims every year, so fashion companies must be able to meet consumer needs. Samase, as a fashion company, has a strong commitment to fulfilling consumer rights, especially in meeting the demands of Muslim consumers. Evidence of this commitment can be seen from the number of agents/distributors spread across the DKI Jakarta area. This study uses a quantitative approach with the aim of proving and analyzing the effect of brand awareness, brand image, and price on purchasing decisions for Samase products in Jakarta. The sampling technique used was purposive sampling, with a total sample of 100 respondents. The collected data were analyzed using descriptive analysis techniques and inferential analysis using the SmartPLS application (V.3.29). The results of this study indicate that: (1) Brand awareness has a positive and significant impact on purchasing decisions, with a path effect of 0.515. (2) Brand image also has a positive and significant influence on purchasing decisions, with a path effect of 0.515. 0.286. (3) In addition, price also influences purchasing decisions positively and significantly, with a path effect of 0.141 Overall, brand awareness, brand image, and price together contributed 0.733 (73.3%) to purchasing decisions, while the remaining 0.267 (26.7%) was influenced by other factors outside this research model.

Investigation of Momordica charantia phytochemicals against PIM1 Kinase: A Computational Approach

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Prostate cancer is a significant contributor to male cancer-related mortality. PIM1 kinase has implications in the development and progression of various cancers, particularly prostate cancer. PIM1, a serine/threonine protein kinase plays a crucial role in cellular processes including survival, growth and differentiation. In prostate cancer increased PIM1 expression is associated with a more aggressive phenotype and poorer patient outcomes. It has emerged as a promising therapeutic target for prostate cancer treatment. The development of PIM1 kinase inhibitors has greatly enhanced and progressed significantly. Different stages of clinical trials demonstrating their potential as therapeutic agents. Momordica charantia, or bitter melon has a long history in traditional medicine for various health conditions, it is very rich in secondary metabolites like triterpenoids, glycosides, alkaloids, flavonoids and phenolic acids. Bitter melon is considered to have medicinal properties including potential anticancer phytochemicals. This study employs virtual screening, molecular dynamic simulation and ADME/T analysis to explore bitter melon’s phytochemicals and their interaction with PIM1 kinase. The goal is to understand the molecular details and pharmacokinetics of bitter melon compounds evaluating their potential as therapeutic agents against prostate cancer. In our present study, it was found that out of all investigated phytochemicals catechin and gallic acid shows satisfactory result depending upon various parameters taken into consideration for conducting the study.