Gene Variants and Epigenetics That Lead to Gender Dysphoria

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These days, the rate of gender dysphoria among transgender individuals has increased drastically. Gender dysphoria is a significant issue affecting every aspect of individuals’ daily activities. It induces significant stress and might eventually cause an impairment. Historically, the etiology of gender dysphoria solely focused on the anatomical aspect, mentioning that men’s and women’s brains are distinct. However, it is now believed to be multifactorial, and emerging researchers are trying to shed light on both brain structures and genes that might contribute to gender dysphoria. To explore the possible etiologies of gender dysphoria, this paper reviews the evidence of how epigenetics contributes to gender dysphoria. The basis includes the role of sex-determining genes, anatomical differences among various populations, epigenetics, and mutation of the RYR3 gene. Epigenetics focuses solely on CpGs methylation. Thus far, these mechanisms could not wholly explain the exact mechanism causing gender dysphoria; therefore, additional research is required to disclose this information. Ultimately, understanding the mechanism of gender dysphoria will promote a better quality of life for individuals experiencing gender dysphoria.

Study of the Processes in Swelling of Expanded Clay Masses Based On Raw Materials of Uzbekistan

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The article investigates the possibilities of obtaining high–quality expanded clay based on the clay of the Gurlen deposit of the Republic of Uzbekistan, with additives from local oil and fat combines – gossypol pitch and local dune sand of Tuprakkala massif. It is determined that the addition of gossypol pitch to the raw mixture within the specified limits significantly increases the swelling of the mass. It was also determined that the addition of dune sand to the mass (together with gossypol pitch) in moderate quantities contributes to an increase in mechanical strength and lengthening of the swelling interval of experimental expanded clay samples.

Transformation of Public Transport Based on Bus Rapid Transit (BRT) and Implementation of Buy the Service (BTS) Scheme in A Metropolitan City of Sarbagita, Bali

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The level of congestion in Indonesia’s big cities, including Denpasar, is already so severe. This is inseparable from the phenomenon where most people in Indonesia now have a car transportation system that is growing rapidly. Furthermore, the city is characterized by high car dependence and a low and steadily declining public transport profile. The Indonesian government seeks to transform the public transportation industry so that drivers want to change to public transportation through the implementation of Bus Rapid Transit (BRT) and most recently, in 2020 the government through the Ministry of Transportation launched the “Buy the Service” program or known as BTS which has been implemented in Indonesia. 5 big cities, namely: Palembang, Solo, Medan, Yogyakarta, and Denpasar. Then followed by Bandung, Makassar, Banjarmasin, Surabaya, and Banyumas in 2021. However, there is an indication that the interest of private car users to switch to using public transportation is very small. The study is intended to evaluate of service or transit improvement. Identify different categories of impacts and how to measure them, discuss the best way to evaluate public transport and identify common mistakes that distort results as well as discuss the travel impacts of changes to the transit system (BRT) and incentives (BTS). The results of this study are expected to explain ways to optimize transit benefits by increasing system efficiency, increasing passengers and creating more transit-oriented land use patterns.

Prediction of Financial Distress on Properties and Real Estate in Indonesia

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Financial distress is a stage of decline in financial conditions which occurred before the onset of bankruptcy. This study was conducted with the aim of knowing the effect of Operating Capacity, Sales Growth, and Debt to Equity Ratio in predicting Financial Distress in property and real estate companies on Indonesian Stock Exchange in 2018-2020. The research method which is used is quantitative research. The sampling technique used purposive sampling method, namely the selection of samples with criteria that have been determined by the researcher. The data used is secondary data in the form of financial statements of property and real estate companies listed on the Indonesian Stock Exchange for the 2018-2020 period. The companies selected as the research sample were 38 companies so that the total observations were 114 observations. Financial distress is included as dummy variable, and it is categorized as 1 (one) for companies which experiencing financial distress and 0 (zero) for companies which is not experiencing in financial distress. The result of this study shows that operating capacity sales growth and debt to equity ratio do not affect the company’s probability of experiencing financial distress.

Transformational and Instructional Leadership Styles to Improve Teacher Performance: Literature Review

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The importance of transformational and instructional leadership styles of principals is interesting to study. There are several articles on Transformational and Instructional leadership style reviews found. This literature review aims to determine the transformational and instructional leadership styles of school principals to improve teacher performance. Based on the results of the literature review, it was found that there was a significant relationship between the transformational leadership style and the principal’s instructional style to improve teacher performance, which was seen from the increase in teacher performance and teacher job satisfaction in schools. The results of the review article show a significant relationship between transformational and instructional leadership styles in improving teacher performance in schools. There is a positive relationship between transformational and instructional leadership styles and can have a positive and significant influence on teacher behavior and teacher job satisfaction. Principal’s Transformational and Instructional Leadership is one of the factors that encourage schools to achieve goals actively and efficiently.

Effect of Cadmium Nitrate on Acute Toxicity of Fish Channa Punctatus at 24 Hr. by Dragstedt and Behren’s Method

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This study was carried out on fish channa punctatus to investigate the lethal concentration of cadmium nitrate on fish channa punctatus at 24 hr.
Experiment procedure was repeated five times at the selected cadmium nitrate concentrations, noting the number of fish killed. The mean value was taken. These values were taken to determine LC50 value for 24 hr.
Toxicity of heavy metals it may be depends upon the dose and time of exposure period.

Alzheimer’s disease: Prevention Strategy

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Alzheimer’s disease (AD) is one of the age-related infections which can develop to Dementia and nowadays both pervasiveness and rate of dementia rise considerably with propelling age Aβ plaques are commonly found in Alzheimer’s patients. neurofibrillary tangles are irregular growth of protein in the brain. Paul Block and George Mannesco believe that Aβ plaques exist, after they discovered circular buildup. AD is eventually caused by neuronal malfunction and death. Aβ cellulose bodies are considered to be less poisonous than Aβ oligomers. A union of blood pressure in adulthood will increase their risk of dementia and Alzheimer’s disease. In the research they found out that old people with 75+ years and the following period are having more risk of dementia and AD. BMI has a bifacial association with dementia and AD has several studies. Due to the uncertain pathophysiological mechanism of Alzheimer’s disease, it is crucial for selecting a precise target population, need for a large sample size, and high cost of the prevention research, it has been a main issue to conduct primary prevention trials. Commonly, healthy seniors are a primary target demographic. Non-pharmacological treatments are helping the patient by enhancing a protective lifestyle like doing physical exercise and a healthy diet. Biomarkers have a priority role to design which group will get in preventative trials, a higher risk of progression of dementia will cut down the studies, however it will decrease the general public’s ability to find the entire community. Primary prevention will evade illness and accomplice pathologies before they arise. Additionally, secondary prevention contains screening to detect disease in its early stages. Tertiary prevention is treating an illness to avoid complex injuries and disability. In a research study, the use of drugs, vitamins, or lifestyle treatments can prevent Alzheimer’s disease, according to the natural definition term the outcome can be a lot of different paths. The possibility of clinical research of AD prevention is full of obstacles.

The Effect of Net Income, Total Cash Flow, And Company Size on Stock Price (Empirical Study on Banking Companies on the IDX)

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This study is to examine the effect of net income, total cash flow and company size on stock prices in the Go Public Banking sector on the Indonesia Stock Exchange (IDX). The population of this study is 43 banks and the research sample is 28 banks that can be
Sampled in the research period 2018 to 2020 and banks that go public on the IDX. This study uses the analysis method of normality test, t test, f test and correlation analysis, determinant coefficient and multiple linear regression using SPSS version 25 software.
The conclusion of this study is that the net income variable (X1) has a significant and positive effect on stock prices, the total cash flow variable (X2) has no significant effect on stock prices and the firm size variable (X3) has an insignificant and negative effect on stock prices. Meanwhile, simultaneously, net income, total cash flow, and company size have a significant effect on stock prices of banking companies listed on the Indonesia Stoct Exchange (IDX) in 2018 – 2020.

Proposed A Loyalty Program 3.0. Case Study: Morinaga Rewards Club

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Indonesia is predicted to become the fourth largest country by world GDP in 2050 by PWC. Human resources on the skills of Indonesian workers are essential factors. Individual workers must be in good health and not lacking in nutrients to achieve optimal productivity. Nutritional intake should start early or in the first thousand days of life. Unfortunately, the rate of stunting or malnutrition in children under five in Indonesia is still above the WHO standard average. The government has made several efforts, including prioritizing breastfeeding for children under one year of age. Baby milk nutrition companies such as Kalbe Nutritional, through the Morinaga brand, support government regulations and participate in nutrition education for babies under five years old. Through the Morinaga Rewards Club loyalty program on a digital application-based platform, Morinaga focuses on the target market of millennial mothers to provide nutrition education and child development. In order to provide a good user experience, the consumer journey at Morinaga is divided into acquisition, activation, and retention. The system integration approach with retail partners and retention modeling Loyalty 3.0 will be applied to increase the number of active users and consumer retention using the Morinaga Rewards Club application.

A Linguistic Communication Interpretation Wearable Device for Deaf and Mute User

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There is a segment of society, which does not have access to today’s sophisticated acoustics, but gesture-based sign language, such as using the hands or the shoulders of the eyes, can be a vital tool for making sure their audio is audible. The most widely used sign language in the world, known as ALC—American Linguistic Communication—varies slightly depending on the nation. Deaf and mute people can communicate effectively by using hand gestures to convey their message. The wearable good glove we developed for this study will translate ALC motions into the proper alphabets and words. It makes use of a glove with a number of flex sensors on the fingers’ distal and proximal interphalangeal joints as well as the metacarpophalangeal joint to detect finger bending. The complete system is divided into three units: a wearable hand glove unit with a flexible device that records user-created ALC gestures, a processing unit in charge of taking sensor data, and a final unit that uses a machine classifier to identify the appropriate alphabet. In order to receive known alphabet data in text form through a wired channel via the mobile “Sign to Speech App,” which presented that text data into this app, the smartphone unit is linked to the processing unit. Its user-friendly design, low cost, and availability on mobile platforms give it an edge over traditional gesture language techniques.