Sustainable Overall Social Transformation: The Problem of Transition

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The paper is devoted to the interdisciplinary item of sustainable development. As follows from the argumentation, it is advisable to expose a concept of universal sustainability, which capturing on a whole the interconnected processes of sustainable changes in society, to the entire process of transformation of society as a social system. It can be named sustainable overall social transformation (SOST), the main criteria attributes of which are defined. In the near future applying described fundamental approach may open the door for ripen implementation the strategy of sustainable transformation at national and supranational levels. In this case the recognized goals/ targets of sustainable development (SDG), including those related to neutralizing climate deterioration, can be achieved at relatively acceptable costs for most modern countries.

Earning Management of Corporate Social Responsibility Mediation and Corporate Governance on Financial Performance (An Empirical Study on Idx Mining Corporates 2016-2020)

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This study aims to examine and analyze corporate social responsibility and corporate governance on financial performance and, through earning management as a mediating variable. Financial performance is the dependent variable which is proxied by ROA and MVA. The independent variables in this study were corporate social responsibility as proxied by 91 GRI 4.0 indicators and corporate governance as proxied by independent commissioners and institutional ownership. Earning management as a mediating variable proxied by discretionary accruals. This study uses a sample of 35 mining companies listed on the Indonesia Stock Exchange from 2016 to 2020. The data used in this study is secondary data analyzed using a multiple linear regression analysis path models with the help of SPSS 25 software, and corporate governance has a positive and significant effect on financial performance. Meanwhile, earning management has a negative and significant effect on financial performance. Corporate social responsibility has a positive and significant effect on earning management, while corporate governance has a negative and significant effect on earning management. Earning management mediates full corporate social responsibility on financial performance, while the board of commissioners partially mediates on financial performance.

Cerebro-Soft Skills of Higher Secondary Students

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This study aimed to investigate the Cerebro-soft skill of higher secondary students which leads to whether the brain dominance of the students influences their thinking or thinking pattern and which leads to show, the problem-solving skills of the individual or not?  This may have the possibility of predicting the creation of unified thinkers or a unique pattern of the people on its own.  Cerebro-soft skills (Brain dominance, thinking styles and problem-solving skills) among higher secondary students do have an impact on their academic achievements.  This study targeted the higher secondary students as population and Kanyakumari, Tirunelveli, Thuthukudi and Virudhunagar districts of Tamilnadu, India as the areas from which the data was collected.  In this research, the above-mentioned population consisted of 135 subjects for this study.  Three unique questionnaires were used to collect the data i.e., the Cognitive style questionnaire (1989) by Loren D. Crane, thinking styles by Robert J Sternberg (2009) and Problem-solving skills by Vengo Regis and Annaraja (2010).  The result of the study revealed that the significant impacts found with the residence of the students in their intuitive problem-solving skills and medium of instructions of the students in their right brain dominance, and type of schools of the students in their right brain dominance, sensing problem-solving skills and thinking problem-solving skills, the significant positive correlation co-efficient found between oligarchic thinking style and anarchic thinking style, hierarchic thinking style and anarchic thinking style, monarchic thinking style and anarchic thinking style which was 64.4%, 46.9%, 44% and 35.8% respectively.

Association of Adiponectin Levels with Polycystic Ovarian Syndrome

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Objective: To measure the levels of adiponectin in women with PCOS having high body mass index.

Methodology: A cross-sectional study including 96 study participants was conducted in Services Hospital, Lahore in December 2020 out of 96 study participants 48 were enrolled as cases having polycystic ovarian syndrome compared with 48 healthy women as controls. Detailed information about age, duration of menstrual cycle, body mass index (BMI), and clinical features like obesity, infertility, acne and hairs on face were noted. A total 5ml venous blood was collected by using aseptic techniques and then centrifuged immediately; serum was separated and stored at -20 °C after proper labeling.  Samples were analyzed for estimation of serum adiponectin by using enzyme linked immunosorbent assay. Statistical analysis was carried out by statistical package for social sciences (SPSS) 21. The p-value < 0.05 was considered to be statistically significant.

Results: In this study level of adiponectin was decreased in PCOS women as compared to healthy women. Mean ± SD of adiponectin in PCOS women was 2.08±0.70µg/ml which was lower than in control group 9.71±5.35µg/ml. Median/Inter Quaitel Range of PCOS women was 2.00/0.78 which is lower in comparison with the Median/IQR of adiponectin in healthy women 8.60/9.63, p-value of   adiponectin was significant (p = 0.00).

Conclusion: Adiponectin is important variable present in circulation. Its levels are changed in response to disease process as occurs in PCOS.

Outcomes of Intraplaque Verapamil Injection for Treatment of Peyronie’s Disease

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Objective: To determine the outcomes of intraplaque verapamil injection for treatment of Peyronie’s disease.

Aim: The purpose of this study is to evaluate the outcomes & efficacy of intraplaque verapamil injection in Peyronie’s disease management.

Methods: The quasi experimental study was conducted from July 2018 to July 2019 on a group of 26 subjects suffering from Peyronie’s disease. After detailed history, complete physical and genital examination, the diagnosis was confirmed. After informed consent, questionnaires regarding pain and sexual satisfaction of patients were filled. All patients received verapamil injections on weekly basis for a period of 10 weeks.  After that, all necessary variables were recorded and data analyzed using SPSS version 16.

Results: Most of the patients in our study were in the age group of 30-65 years. 26.9 % patients were in the range of 51-55 years old. 53.8% patients got no effect of intralesional injection of verapamil on pain while pain relieved in 38.5% of patients  & 7.7% patients experienced an increased in pain intensity after 10 weeks of intralesional injection of verapamil. 61.5%of patients satisfied with their sexual life after 10 week of injections & 30.8% of patients remained unsatisfied with their sexual life while in 7.7%of patients symptoms aggravated. 53.8% of patients experienced no change in size of lesion and curvature of penis, while 30.8% got less than 50% reduction in size of lesion while 15.4% of patients got more than 50% reduction in size after 10 weeks.

Conclusion: This study concluded the efficacy of Verapamil injection for management of Peyronie’s disease.

Finding the Relationship of Smoking and Survival Rate in Oral Submucous Cancer Patients

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Introduction: Cancer is a global public health issue, causing approximately 8.8 million deaths per year. According to the World Health Organization (WHO), the countries that suffer most from the disease are low-income and middle-income countries. Objectives: The main objective of the study is to finding the relationship of smoking and survival rate in oral submucous cancer patients.

Material and methods: This cross sectional study was conducted in Services Hospital, Lahore during 2021. The data was collected from 204 patients. From this sample socio-demographic data such as age, sex, education, marital status, smoking status, and method of hospital admission were analyzed.

Results: The data was collected from 204 patients. Most patients were up to 65-year-old, with no difference in age distribution between the groups. Regarding the type of treatment, nonsmoking patients complied with no treatment, surgery or surgery plus radiotherapy (RT), with RT associated with chemotherapy (CT) being the most common treatment.

Conclusion: It is concluded that we found the significant positive dose-response relationship among smokers on clinical outcome in OSCC patients and that non-smokers were worse prognosis than light smokers. In addition, this effect might differ by treatment method.

A Triple Helix Approach for the Diffusion of Blockchain Technology against Counterfeiting of Made in Italy Products in SMEs of the Marche Region

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This paper describes the opportunities that blockchain technology applied to product traceability might offer to firms of Made in Italy against counterfeiting of their products, and the challenges to the adoption of blockchain technology in these firms, especially SMEs. The focus is on the Italian Region Marche which is characterised by a prevalence of firms specialised in the Made in Italy. The paper proposes a triple helix approach to facilitate the diffusion of blockchain technology in the Marche Region and individuates policies and non-academic actors at the regional level that could help SMEs to know and adopt this innovative technology.

Development of Student E-Worksheet Based on PBL (Problem Based Learning) to Practice Metacognitive Abilities of High School Student on Reaction Rate Material

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Developments in the 21st century is so rapid that innovation in various fields is required one of which is education. Through the implementation of the 2013 curriculum, the metacognitive abilities needed in the 21st century were train. The Problem Based Learning (PBL) model can support students to develop their metacognitive abilities. The rate of reaction as one of the subjects that are difficult to understand can be taught through the PBL learning model. The aim of this study is to develop a Student E-Worksheet based on Problem Based Learning to train students metacognitive abilities on reaction rate material. The Student E-Worksheet development model in this study uses a 4D model. The development of Student E-Worksheet was declared feasible to train student metacognitive abilities. The results of content validity of 94.81% and construct validity of 96.97%. Then the results of practical of observing student activities and questionnaire with a value of 96.37%. The effectiveness of the Student E-Worksheet is seen from the pretest and posttest values ​​which were analyzed using the SPSS Paired Sample t-Test test, a significance value of 0.000 was obtained.

Assessment of Challenges Experienced Among Households on Promotion of Sanitation Practices in Tigania West Sub County, Meru County, Kenya

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A poorly constructed toilet may deter its use and provoke open defecation. Globally, 2.5 billion people do not have access to improved sanitation facilities. In Kenya, over 5 million people are forced to defecate in the open due to challenges associated with toilet construction and use resulting in high prevalence of water, sanitation and hygiene-related diseases such diarrhea. This study therefore sought to profile the challenges experienced on promotion of sanitation practices among households in Tigania West, with a view of yielding insights on promotion of safe disposal of human waste. Questionnaires, interview guide and observations were used to collect data in a mixed study design. Systematic and purposive sampling technique was employed to select respondents and the data analyzed using SPSS version 21.0 and audio recordings were transcribed into text and then analyzed thematically.  73.4% of the residents lacked adequate space for toilet construction and (26.6%) who did not. (69.1%) of respondents had limited toilet construction materials, (11.8%) had challenge in toilet construction in rocky soils. Loose/collapsing soils were 9.4% (4.6 %) and financial constrains were (5.1%). 75.3% encountered culture challenges which affected toilet construction. More than half 64.9% had problems with sanitation facilities sharing (n=225).Sanitation practices had a significant positive correlation with cultural practices (0.119 (p=0.003<0.05), sharing of toilets (0.142; p=0.002<0.05), space availability in the household (0.098; p=0.004<0.005) and financial challenges (0.074; p=0.004<0.005). Innovative approaches to toilet construction using locally available materials, training and subsidies together with behavioral change sensitization could improve sanitation among households of Tigania West Sub-County.

How Does ESG Score and Board Structure Affect Financial Performance? Evidence from ESG Sector Leaders IDX Kehati

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The rise of sustainable investing, an investing strategy considering ESG (environmental, social, governance) factor of the company has spread worldwide, including in Indonesia. Recent phenomena of minimum percentage of woman on board in state-owned enterprise policy by Indonesia Ministry of State-Owned Enterprise and the new two ESG themed index which consists of state-owned enterprise has intrigued to assess the relationship between board structure towards financial performance of the companies. One of the index is “ESG Sector Leaders IDX KEHATI“ which  comprises of stocks with an ESG performance assessment above their industrial average value. Using ROA and ROE as the dependent variable and ESG and board structure variables and firm size, asset to equity ratio, and firm age as control variables. It is found that ESG has negative non-significant relationship towards both ROA and ROE. Board independence and board gender diversity has positive significant effect towards both ROA and ROE.