HCT116 Cells Cytotoxic Response to Multifuctionalized 5- Fluorouracil MWCNTs Conjugates In Colorectal Cancer

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Nanomaterials are the foundations of Nanotechnology, which are measured in nanoscales, Carbon nanotubes are one of the interesting nanomaterials, studied for over 25 years because of their superlative properties such as high surface area, electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion and nanosize. According to research, carbon nanotubes are applied in sensing, water treatment, and drug delivery, mainly used to deliver the anticancer drugs. In our work, functionalization of multi walled carbon nanotubes done by covalent and non-covalent functionation methods, covalent functionalization showed better dispersing efficiency in aqueous medium and compatible with biological systems with damaging the crystal lattice of carbon nanotubes. Non covalent functionalization helps to derivatized with active compounds, surface adsorption or attachment of various molecules or antibodies, which subsequently helps in targeting the site and to produce therapeutic effects. Different formulations prepared by functionalized MWCNTs and multiple functionalization of MWCNTs done by binding the drug and antibodies to prepare functionalized MWCNTs 5-Fluorouracil complexes. The Cytotoxicity assay was carried out for the obtained new targeting formulations to analyze the effect of all the formulations on HCT116 cell line. The percentage death was determined based on the viability of the cells in the appropriate vehicle controls. In this study, we report the successful functionalization, binding of 5 Fluorouracil, antibodies to MWCNTs, and cells viability of all prepared formulations for the development of novel carbon based anticancer drug delivery system. Functionalized MWCNTs-5-Fluorouracil antibodies composite at concentration above 2.5 µg/mL exhibited ≥ 50% cytotoxicity post normalization with compound control to negate precipitation observed with the compound. All the formulations showed the precipitations indicating antitumor activity and biocompatibility.

Transition and Adjustment of First-Year Student College in Dormitory: A Literature Review

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The importance of transition and adjustment of students in the first year is interesting to study, and this paper examines the role of campus dormitories in assisting first year students in their transition and adjustment. There are several articles on reviews of transitions and adjustment of first-year students to be found. The purpose of this review is to find out the role of dormitories in the transition and adjustment period of first year students. Based on the results of a literature review, we found that campus dormitories can help students in transitioning and adjusting to their first year.

Participative Leadership Practice in Asia Context: A Literature Review

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The importance of participatory leadership practices in schools attracts researchers to research, and this article is used to test how participatory leadership practices in schools. The review process begins with a search engine, Google Scholar, to search for articles with keywords, participatory leadership. There are several articles on the review of participatory leadership practices especially in the Asian context, which can be found. The purpose of this review is to investigate participatory leadership practices at schools in the Asian context. Based on the results of literature reviews from various countries in Asia, we find that practice. Strong participatory leadership can create structures to facilitate the work of teachers by strengthening organizational belief systems and these factors together encourage student learning and leadership is carried out persuasively creating harmonious cooperation, fostering loyalty and participation of subordinates.

Human Resource Management Development in the Face of Covid-19 Pandemic

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The novel coronavirus, COVID-19 pandemic, has caused numerous unprecedented changes recorded globally in all spheres of life especially in the work place. This has implications and influences on the companies and human resource management (HRM). Organizations have had to respond speedily by reviewing many operational matters and strategies so as to be able to manage the effects of the pandemic. Human resource management (HRM) plays the essential role of helping organisations navigate through both the iffy present and unpredictable future caused by the pandemic lockdown by managing people to cope with stress and to continue working, even remotely, when applicable, so that businesses can go on with their operations. This paper embraced analytical discussion of secondary data and using self-determination theory as its theoretical framework, it assessed the implication of HRM; having knowledge of the effects of autonomy, competence, and interrelatedness in their dealings with employees on sustained HRM development in the pandemic era. The aim of this research is to look into notable human resource management practices developed in the quest to accommodate and tackle the magnitude of HRM challenges faced by organizations during the COVID-19 pandemic and the challenges encountered by employers and employees in imbibing them. The research recommended that HRM should help employees in their quest to develop their competences through trainings, consulting, and coaching as this will help in accomplishing the organizations’ goals and vision in the post COVID-19 pandemic era. An empirical research in this area is advocated to aid long-term HR policy.

Emerging Concepts and Practices in Post-Harvest Management of Horticultural Crops Revisited

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This paper offers a comprehensive account on the emerging concepts and practices in post-harvest management of horticultural crops. Post-harvest science and technology facilitates the industries to deliver safe, nutritious and fresh horticultural products to consumers at the end of the supply chain from farm to mouth. Substantial food wastages, which occur in the post-harvest period and such losses, could be reduced by improved post-harvest research, advancement, training and education. At present, many novel technologies and techniques are already being implemented to reduce the post-harvest losses which are witnessed at harvesting, during packing and transportation, in wholesale and retail markets, and during delays at various levels of handling. Improvements are also required to minimize the losses effectively and keep the process-cost low so that it could be applicable at commercial scale in a wide range of economic levels. By developing the practices utilized at post-harvest phase, the expenses accompanying for additional processing paces could also be reduced. Future studies should also be focused on incorporating various emerging technologies with post-harvest practices and appropriate improved practices should be adopted to an existing value chain and marketing system.

The Study of Inflation Rate and Relative Impact on the Indian Economy during Covid-19 Pandemic

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COVID-19 has affected the entire world. India, like other countries have adopted the safest way of lockdown in order to prevent the pandemic. One of the most critical impact of lockdown is increasing inflation. Covid-19 has affected the economy in many ways, but the most tangible outcome is the impact of inflation that has affected each and every person. Even into the pandemic, Inflation in India did not see it going below 6%. Inflation has been one of the most burning issue of economics. It is an increase in the prices of daily commodities over a period. This paper is an attempt to understand the impact of inflation on Indian economy during COVID-19. The paper looks at the methods that are used to measure the level of inflation, and the factors that are responsible for the current high level of inflation in India during COVID-19.

Behavior of Educational Organizations in Education for Sustainable Development

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This article deals with a literature review of internalizing Education of Sustainable Development (ESD) in Indonesia. The approach used in this research is a qualitative approach with a comparative descriptive method. Sustainable development is not only a way to overcome environmental crises, but also social and economic crises experienced in various parts of the world. One form of education that can have a major impact on development is Education for Sustainable. Development (ESD). Education for Sustainable Development enables every human being to acquire the knowledge, skills, attitudes and values needed to shape a sustainable future. The implementation of ESD in each school has various variations according to the school’s perception. The condition of the school background is correlated with efforts to implement ESD practices. The supporting factor for the implementation of ESD in elementary schools is if the school has a good concept and implementation related to aspects of school policy, school strategy, conception of implementing components and commitment to implementing activities. The inhibiting factor for the implementation of ESD in elementary schools is if the school does not have good policies and strategies related to ESD development and a low level of awareness regarding the conception and commitment to implementing ESD-based activities.

Formulation and Evaluation of Ranitidine Hydrochloride Loaded Floating Microspheres for the Treatment of Gastric Ulcer

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The study was aimed to prepare gastro retentive floating microsphere of Ranitidine Hydrochloride by Ionotropic Gelation technique and solvent evaporation technique by using the different carriers’ ratios (Carbopol 934, Chitosan, and sodium alginate). Both natural and synthetic polymers have been used to prepare floating microspheres and evaluated the relevant parameters. There was no drug and carrier interactions assessed from FTIR. Depending upon the ratio, the percentage yield was found between 58.33% to 90.38%. in all formulations. The surface morphology of microspheres was characterized by SEM and it was discrete, spherical in shape with rough outer surface and showed free flowing properties. The mean particle size of microspheres significantly increases with increasing polymer concentration and the range between 99.92±1.221 to 168.23±1.963 µm. Among all the formulations, RF3 showed high drug entrapment efficiency (87.52%). The percentage in-vitro buoyancy of the floating microspheres was in the range of 66.92% to 81.52%. The in-vitro drug release study revealed that RF3, RF6 and RF9 Formulations having 89.97%,92.91%,93.68% drug released at the end of dissolution studies respectively. It could be concluded that the developed floating microsphere of Ranitidine Hydrochloride can be used for prolonged release in stomach. Therefore improving the bioavailability and patient compliance.

Effect of Compensation, Work Motivation and Work Discipline on Employee Performance of Zulu Alpha Papa Company

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Representative execution is a determinant of the advancement or decay of an organization, worker execution is impacted by a few variables including remuneration factors, inspiration factors, and work discipline factors, from these components we can see the organization’s usefulness, since representative execution will be straightforwardly corresponding to organization efficiency, on the off chance that representative execution expands, organization usefulness additionally increments, despite what might be expected assuming worker execution diminishes, organization efficiency likewise diminishes. The reason for this examination was to decide how the impact of pay, inspiration, and work discipline on worker execution at PT. Zulu Alpha Papa. This examination strategy utilizing subjective techniques with the number of tests utilized in this investigation were 120 respondents who were disseminated haphazardly to representatives of the PT. Zap head office. Inspecting strategy utilizing soaked example while information examination utilizing way investigation procedure (Path Model) which is upheld by Smart PLS programming variant 3.0. Because of this examination, the outcomes showed that there was a positive and huge impact among pay and worker execution, there was a positive and huge impact of inspiration on representative execution, there was a positive and huge impact of work discipline on worker execution, remuneration, inspiration, work discipline at the same time had a positive impact and important to worker execution.

The Implementation of Learning Management in the Covid-19 Period in Junior High Schools in Indonesia: A Literature Review

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Learning management during the Covid-19 period is important, because it will be able to reduce student boredom in online learning. In addition, by implementing appropriate learning management, it will also be able to help students and teachers to adapt quickly to Covid-19 situation. This study aimed to discover and search for some possible ways on how to implement learning management in Junior High Schools during the Covid-19 period. The method used in this study was literature review with a qualitative research concept. The results of the study indicated that the implementation of learning management during the Covid-19 period in Junior High School was carried out by three ways, namely 1) providing social support for students to complete their school work, 2) teachers carry out learning management by reforming learning methods, and 3) good communication management between teachers and students using a platform or application that was in accordance with the material at school.