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Depression is a global mental health challenge with significant social and economic burdens. While conventional pharmacological treatments have been the cornerstone in depression management, there is a growing interest in exploring alternative and complementary herbal therapies. Herbal interventions have emerged as promising therapeutic approaches for depression treatment. Both clinical and preclinical research has shown that individuals with depression often experience simultaneous activation of neuro-inflammatory response within immune system and heightened activity in hypothalamus pituitary-adrenal (HPA) axis of  neuroendocrine system. These two systems interact with each other bidirectionally through neural, immunological and humoral mechanisms. This review article provides an outline of the current progress of research on herbal interventions, emphasizing their potential as emerging therapeutics for depression. It discusses the mechanisms of action, safety profiles, and evidence from clinical studies supporting the use of various herbal remedies. Herbal interventions and traditional Chinese formulations hold promise as a valuable adjunct or alternative to conventional treatments, offering new avenues for the comprehensive care of individuals with depression.