Articles

A Brief Review on Solubility Enhancement Techniques with Drug and Polymer

/in /by

The process of a solid dissolving in a liquid phase to create a homogenous mixture is known as solubility. A crucial factor in getting the right quantity of drug into the bloodstream to show a pharmacological effect is solubility. The main issue in developing formulations for new chemical entities as well as for the creation of generics is low water solubility. More than 40% of novel chemical entities (NCEs) created in the pharmaceutical sector are essentially water insoluble. For formulation scientists, solubility is a significant challenge. Any medicine that is to be absorbed at the absorption site must be there in solution form. The solubility of pharmaceuticals that are poorly soluble can be improved using a variety of approaches, such as complexation, salt formation, particle size reduction, crystal engineering, salt formation, solid dispersion, and the like. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. This review article’s goal is to improve bioavailability and promote effective absorption.

In Vitro Determination of Fe Levels and Fe Bioavaailabilities Prediction from Dahlia Tuber Syrup (Pinnata Cav.)

/in /by

Dahlia tubers (Pinnata Cav.) with red flowers are known to have high inulin and fructooligosaccharides (FOS) in their tubers, they also contain various minerals such as Fe and others which are needed by the human body. Therefore, this study was conducted to discuss in vitro determination of Fe levels and Fe bioavailabilities prediction from dahlia tuber syrup. The Fe content in the Dahlia tuber syrup was determined experimentally using the X-Ray Fluorescence Spectrometer (XRF) instrument. The Fe bioavailability of dahlia tuber syrup was predicted based on the standardized inulin and FOS content of dahlia tubers against yacon tubers. The results showed that the Fe content in dahlia tuber syrup was 10,2 ppm. The bioavailability of Fe in dahlia tuber syrup in vitro is predicted to be 69.20% – 94.73%. The prediction of a fairly high Fe bioavailability indicates that dahlia tuber syrup is expected to be quite good in increasing the absorption of Fe in the body which can have health effects, among others, can play a role in improving body metabolism and being able to reduce the risk of anemia due to iron deficiency.