Articles

Isolation and Morphological Characterization of Actinomycetes from Industrial Soils and Analysis of Their Biodiversity

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The industrial area of Bhilai was selected for soil sampling, and samples were collected from various sites. Soils near industries are affected by industrial effluents. The industrial impact on soil is primarily through chemical contamination, physical alterations, and changes in microbial communities. Five soil samples were collected from chemical, iron, and steel manufacturing regions, highlighting the diverse impacts of these industries on soil health. These samples will undergo rigorous analysis to determine the extent of contamination and assess the overall ecological risk posed to the surrounding environment. Industries are located in different areas. Soil samples were analyzed for their physical and chemical properties using standard methods. A total of 29 isolates were obtained from different soil samples. The isolates were characterized primarily by their morphology, which included size, shape, configuration, elevation, margin, pigmentation, and the presence or absence of aerial and substrate mycelia. This study provides detailed and analytical information on the distribution of actinomycetes in industrial soil. The results also revealed their ability to produce secondary metabolites that inhibit microbial growth.

Royal Jelly (Apis mellifera) As an Antimicrobial Activity Inhibition

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Royal jelly (RJ) has lots of compounds such as protein, vitamins, and a variety of bioactive compounds (10-hydroxy-2-decanoic or 10-HDA acids). 10-HDA is a lipid fraction component in RJ content with antibacterial and immunomodulatory activity. RJ proteins that have antimicrobial, antifungal, anti-tumor, antidiabetic, and antihypertensive properties. The authors continue their research about the effect of RJ on the inhibitory strength of the given antibacterial activity. L. monocytogenes, S. aureus, and E. coli were among the microbes studied in this research. This study used an experimental method with a complete randomized design (CRD) of 5 treatments and 4 replications, if the treatment showed a noticeable effect (P<0.05) then Duncan’s multiple distance test was continued. According to the findings of this study, the royal jelly variations given had a significant inhibitory effect on antibacterial activity. The inhibitory ability of L. monocytogenes proved that the second treatment had a higher inhibitory power of 30.94±25.786b, in S. aureus, the second treatment gave a moderate inhibitory power of 9.013±1.841a, and in E. coli, the second treatment gave a weak inhibitory power of 3.24±3.748a. The conclusion of studies showed royal jelly with dilution variety could be antimicrobial agent and to be strongest inhibitor in L. monocytogenes and lowest in E. coli. The suggestion of studies needs management in the isolates of bacteria available and should be estimated before we do the research about antimicrobial activity inhibitors.

Cassia tora Linn. – A Pharmacological Review

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Cassia tora Linn. is one of the widely  used plants  in ethnic and traditional systems of medicine. A popular species in the genus Cassia, its therapeutic effects on ocular system, integumentary system, hepato pancreatic disorders, gastric system have been documented since centuries and demonstrated through pharmacological experiments. The efficacy of the seeds and leaves may be attributed to presence of anthraquinones glycosides phenolic glycosides, sennosides and flavonoids.  Cassia tora need to evaluated for its unexplored health benefits through new scientific investigations in tackling emerging diseases and life style disorders.

A brief review on Triazole and its Pharmacological Application

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The triazole core is one of the most imperative and well known heterocycles which is composed of nitrogen atom which forms natural products with medicinal claims. Triazole moiety is present as a principal structural component in the drug categories such as antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepressant, antioxidant, antihistaminic, antitubercular, antidiabetic etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant platforms. The elementary heterocyclic rings present in the numerous medicinal mediators are 1,2,3-triazole and 1,2,4-triazole. A huge capacity of investigations has been approved on triazole and their results, which has proved the pharmacological status of this heterocyclic core. The current paper is an try to review the pharmacological activities reported for triazole derivatives in the current literature with an apprise of current research discoveries on this nuclei.