The Results of Vaccination and Reversed After Vaccination of Coronavirus Infection in Fergana Region for 2021–2022

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In this study, an analysis of the incidence of COVID–19 in the Fergana region was carried out, the number of vaccinated vaccination coverage and those who recovered after vaccination with COVID–19 was determined. The incidence was studied for the period from March 2020 to 2022. Since vaccination began in 2021, we analyzed those vaccinated and recovered from 2021 to 2022. The dynamics of the incidence of COVID–19 in the Fergana region was undulating. During the surveyed period, the intensive indicator of the incidence of COVID–19 was as follows: in the city of Fergana (887.6), Kuvasay–1169.5, Kuva–995, Sokh–737.2, Yazyavan–781, Altiarik–610.1, Fergana–472 cases per 100,000 populations. During this period, more than 7 million doses of COVID–19 vaccines were administered, and no side effects of the vaccines used were observed among those vaccinated.

Increasing the Effectiveness of the Budget Organizations through the Influence of Financial Control

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The article examines the issue of increasing the effectiveness of the budget organizations through the influence of financial control. In addition, the article studies research papers of scholars–economists on financial control, the activities of financial control bodies to ensure the purposeful spending of funds of budget organizations, as well as analytical operations performed. In reliance upon the research outcomes, the author has developed relevant conclusions.

The Significance of Financial Control in Ensuring Targeted Spending in Vocational Education Institutions

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This article is devoted to consideration of the significance of financial control in ensuring the targeted spending in vocational educational institutions. Research papers of economists on the concept of financial control have been investigated and the impact of financial control contributing to economic efficiency has been analyzed. In reliance upon the research results the author has developed relevant proposals and recommendations.

A Study to Assess the Association between Malnutrition and Anemia in Underfive Children by Using two Binary Variables of Haemoglobin Crest and Low Height for Age and Low Degree of Malnutrition at Nerkundram

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Background: Anemia, which is characterized by low level of hemoglobin in the blood, is one of the major public health hazards affecting people in both developed and developing countries. Anemia may occur at all stages of life, however, young children and women in the childbearing age are the most vulnerable. When anemia occurs in children, it could affect their cognitive performance and physical growth  In women, anemia could adversely affect their capacity to work and may lead to poor pregnancy outcomes.

Methodology: Data collection was done in selected community area of Nerkundram, for a period of 1 week. The investigator obtained written permission from the Principal, Saveetha Medical College and Hospital, Chennai and in charge of selected community area, Nerkundram. An oral consent was obtained from the samples prior to the study. The purpose of the study was explained to the subjects. The samples who fulfilled the inclusion criteria were selected. The purposive sampling technique was used to select 200 samples for the study. Everyday 25 samples were selected and collected data from them. Demographic data was collected by administering the structured tool and the biochemical variable hemoglobin was assessed clinically. The data collected were then coded and entered in Excel for further data analysis and interpretation.

Results: 200 in total Participants finished this research. After 1 weeks, The present study assessed the association between malnutrition and anemia in underfive children by using two binary variables of haemoglobin crest and low height for age and low degree of malnutrition. The study concluded that most of the underfive children had moderate to mild anemia and the parents of underfive had to be educated on malnutrition and the steps to prevent anemia.

The Utilization of Potential Water Sources in the Development of Swiftwater Ponds and Sentool Agrotourism, Suci Village, Indonesia

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Suci Village is a village located in Panti District, Jember Regency, East Java, Indonesia. This village is an area rich in natural resource potential, especially water sources. The availability of this water source can be caused by the large number of plants that are able to store abundant amounts of water. Based on its abundant water sources, this village can be used as a potential attraction in itself. There are several small rivers that can be used to develop fast water pools. Apart from that, the development of small rivers in Sentool tourism can be used as fast water pools and agrotourism in Suci village has great potential in improving the economy of local residents. With abundant water resources, communities can develop agrotourism businesses that can attract tourists, thereby creating jobs and improving the local economy. The Grand Launching of Fast Water Fish Tourism is an event involving enthusiasm and excitement which aims to introduce a new destination, namely fast water fish tourism, to the wider community. Providing culinary training in Sentool Village could be a good step to develop the tourism and economic potential of the local community. Cycling to explore plantation areas for tourist purposes is an interesting way to introduce tourists to agricultural environments, plantations and natural beauty that they may have never seen before. Pokdarwis Training Conduct initial assessment to identify. Tourism management, marketing, tourism product development, cleanliness, security and guest service then design a training program that suits your needs. Tour guide training in Sentool village is an important step to ensure that tour guides have the knowledge and skills necessary to provide visitors with a satisfying tourism experience.

Perspectives of the HACCP System in the Alembic Cachaça Certification

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Cachaça is the name of a Brazilian beverage produced by distillation of fermented sugarcane juice. It is called “alembic cachaça ”  when produced in an agricultural environment, through fermentation of fresh sugarcane juice and distillation by batches in copper stills.  Due to the peculiarities of the process and the dedication of hundreds of producers, this drink achieved improved and highly differentiated sensory quality; conquering new markets and winning important prizes in national and international competitions. In this context, there is a growing search both for resources to prevent fraud in marketing and for certificates that attest to the safety of consumers’ health, especially HACCP. In this review article, we highlight the points already achieved in the standardization of the production process and introduce others that still require appropriate standardization, related to the control of pesticides in the sugarcane field, the safety of the wood used in the storage barrels and the certification of the production process. It is also proposed to review the limit of Brazilian legislation for the ethyl carbamate content.

Analysis of Social and Behavioral Impacts of Covid-19 Pandemic in Community-dwelling Older Adults Screened for Insomnia

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Objectives: This study sought to understand the impacts of the COVID-19 pandemic on older adults screened for the Nursing Diagnosis Insomnia (00095).

Methods: Secondary cross-sectional data analysis from a parent study on insomnia in older adults, using Bardin (2011) content analysis. Data from 77 older adults were collected from qualitative February to May 2021 in the pandemic period.

Results: Four thematic categories emerged: (1) Physical exercises; (2) Social impacts; (3) Physical and mental health; (4) Finances. The Physical and mental health category was most representative both in negative perceptions and in positive or neutral perceptions about the pandemic. The excess of bad news generates a negative perception. On the other hand, some older adults enjoyed benefits, such as improved sleep.

Discussion: The verbalized feelings are interconnected, and these spheres of life complement each other, interfering with each other. It is suggested to produce nursing strategies for older people and studies that address nursing interventions in pandemic periods.

The Influence of Work Competence and Work Motivation on Employee Performance at PT Hardware Clothing Area Banjarbaru

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The aim of this research is to determine: (1) The influence of work competency and work motivation simultaneously on employee performance. (2) The partial influence of work competency and work motivation on employee performance. (3) Which variable is the most dominant between work competence and work motivation on the performance of PT Hardware Clothing Area Banjarbaru employees. This research is quantitative research with a correlation design. Sampling was carried out using a saturated sampling technique with 30 respondents. The data collection technique uses a questionnaire method, then the results of the questionnaire are tested on instruments to test their validity and reliability in order to obtain results that are in accordance with the facts. Next, the data analysis technique is carried out using classical assumption tests, namely the normality test, heteroscedasticity test, and multicollinearity test as regression test requirements for hypothesis testing. The hypothesis test used is multiple linear regression analysis. The results of this research show that work competency and work motivation simultaneously influence employee performance. Partially, work competency has a significant positive effect on employee performance, while work motivation partially has no significant effect on employee performance. Work competency has the most dominant influence on employee performance.

Nutrient Content of Pig Feed Based Local Feed Mixed with Liquid Fermentation Products from Moringa and Azadirachta indica Leaf Extracts

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This research aims to determine the nutritional content of rations based on local feed mixed with liquid Moringa leaf extract and fermented Azadirachta indica as pig feed. The research materials used were Moringa leaves and Azadirachta indica which were extracted and liquid fermented as well as local rations. In this study, an experimental method was used with a completely randomized design consisting of 5 treatments and 4 replications. The treatment in this study was R0; ration without liquid fermented extract, R1; ration + 10% liquid fermented extract, R2; ration + 20% liquid fermented extract, R3; ration + 30% liquid fermented extract, R4; ration + 40% liquid fermented extract. The data obtained were analyzed using analysis of variance. Based on the research results, the crude protein content (%) R0; 13.90±0.40, R1; 15.02±0.12, R2; 17.73±0.88, R3; 19.20±0.29, R4; 20.22±0.41, crude fiber content (%) R0; 7.10±0.18, R1; 6.90±0.27, R2; 6.85±0.39, R3; 7.08± 0.17, R4; 7.04±0.14, non nitrogen free extract content (%) R0; 48.69±1.88, R1; 49.42±0.48, R2; 47.54±0.79, R3; 46.14±0 .79, R4; 45.34±0.72, gross energy content (kcal), R0; 3524±45.55, R1; 3620±26.77, R2; 3698±19.24, R3; 3742±10.88, R4; 3770±31, 28. The results of statistical analysis showed that the treatment had a significant effect of P<0.05 on crude protein, non nitrogen free extract, energy content, but had no significant effect of P>0.05 on crude fiber content. The conclusion of this research is that the addition of fermented Moringa leaf extract and Azadirachta indica liquid to local pig rations has an effect on increasing protein and energy content with an average increase in protein content of 3.36% and energy of 107.73 kcal. for each increase, add 250 ml of liquid Moringa leaf extract and fermented Azadirachta indica to the local ration.

Ameliorative Role of Grape Seed Extract (Vitis Vinifera) on Gemcitabine- Induced Testicular Damage in Rabbits

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Spermatogenesis is a highly conserved and regulated process and it is sensitive to fluctuations in the physical and chemical environment. Gemcitabine is a novel antimetabolic anticancer drug used frequently in the treatment of many cancers. Gemcitabine may disrupt spermatogenesis by targeting various testicular cell types. Grape seed extract is a natural product, recently identified as one of the most powerful antioxidants. In addition, it has been reported to exert anticarcinogenic effects.

This current work aimed to study the effect of gemcitabine on the testicular tissue of local adult rabbits and to evaluate the possible protective role of Grape seed extract.

A experimental study was performed on twenty seven  adult male local rabbits, were divided into three  groups,  nine rabbit in each group as following: group (A): animals of control group received normal saline injection,  group (B): animals of treated group received therapeutic dose of gemcitabine alone in a dose of 25 mg/kg body weight intraperitoneally once per week for six successive weeks and group (C): served as protective group and was concomitantly treated with grape seeds extract by oral gavages in a dose of 250 mg/kg body weight  and gemcitabine in a dose of 25 mg/kg body weight intraperitoneally once per week for six successive weeks.

The results of the present investigation showed that gemcitabine toxicity produced significant structural changes in the testis of group B, gemcitabine treated group, in the form of multiple distortion of the seminiferous tubules, with cellular disorganization, testicular tubular cell degeneration, necrosis, tubular atrophy, desquamation and sloughing of the seminiferous epithelium which was accumulated in the centre of the seminiferous tubules in the form of degenerated tissue.  Many seminiferous tubules showed widely spaced spermatogenic cells. Karyopyknosis, disappearance of interstitial cells of Leydig and necrotic Sertoli cells, progressive tubular and interstitial testicular damage together with spermatogenic arrest was an initial necrotic change induced by gemcitabine exposure. Disorganization of spermatogenic cells, an interruption in spermatogenesis process and the seminiferous tubules are devoid of sperms was also showed in this study.

Sections from the testes of animals received therapeutic dose of gemcitabine and treated by grape seed extract, group (C) were showing partial preservation of the normal structure of the seminiferous tubules. Most of them more or less resembled the normal structure.

It could be concluded that gemcitabine caused marked alterations in the structure of the seminiferous tubules of the rabbit testis that may be minimized by administration of grape seed extract. Our findings simply revealed that grape seeds extract treatment significantly inhibits testicular cell apoptosis, which suggests that apoptosis may be one of the underlying mechanisms by which grape seeds extract protects against gemcitabine induced defective spermatogenesis.