Dynamics of Erythrocyte Sedimentation Rate vs. C – reactive protein: Peas in a Pod or Chalk and Cheese?

Acute phase reactants have a supplementary role in the management of hospitalized patients with fever. While not perfect tools, they have some role in formulating a diagnostic and therapeutic plan and may improve antimicrobial stewardship. The Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), while not specific enough to establish a diagnosis, can be helpful in guiding the intensity and duration of anti-infective therapy. However, they have different dynamics during inflammations and infections.