Articles

A Brief Review on Solubility Enhancement Techniques with Drug and Polymer

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The process of a solid dissolving in a liquid phase to create a homogenous mixture is known as solubility. A crucial factor in getting the right quantity of drug into the bloodstream to show a pharmacological effect is solubility. The main issue in developing formulations for new chemical entities as well as for the creation of generics is low water solubility. More than 40% of novel chemical entities (NCEs) created in the pharmaceutical sector are essentially water insoluble. For formulation scientists, solubility is a significant challenge. Any medicine that is to be absorbed at the absorption site must be there in solution form. The solubility of pharmaceuticals that are poorly soluble can be improved using a variety of approaches, such as complexation, salt formation, particle size reduction, crystal engineering, salt formation, solid dispersion, and the like. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. This review article’s goal is to improve bioavailability and promote effective absorption.

A Review on Novel Drug Delivery System Nanoemulsion

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various researcher are innovate a replacement therapy regarding improvement of drug action. Improve drugs absorption, distribution also we improve its efficacy. Amongst that a replacement innovative technology are develops. A nanoemulsion is technique to enhance the solubility, bioavability, pharmacokinetic and pharmacodinemics of medicine .in this review article us familiar about the novel technique nanoemulsion and its preparation methods, charactorization of nanoemulsion. Nanoemulsion has been identified as a promising delivery system for various drugs including biopharmaceuticals. Nanoemulsion may be a heterogeneous system composed of one immiscible liquid dispersed as droplets within another liquid. The droplets size of nano emulsion is between 20 to 500 nm. Diameter and surface properties of droplets of nanoemulsion plays a crucial role in the biological behavior of the formulation. Small droplet sizes cause transparent emulsions so that product appearance is not altered by the addition of an oil phase during this paper various aspects of nanoemulsion have been discussed including advantages, disadvantages and methods of preparation. Furthermore new approaches of stability of formulation, effect of types and concentration of surfactant, process variables and method also are discussed to improve the stability of nanoemulsion formulation.