Articles

A Green approach of Ag and Au Nanoparticles, Properties and its Applications: A Review

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The emergence of nanotechnology has transformed antimicrobial and cancer treatment methodologies employed by clinicians. Conventional approaches, such as, radiotherapy, hormonal therapy and chemotherapy, now have a contemporary counterpart in nano therapy, presenting a potential alternative. This innovative treatment paradigm holds promise due to its minimal side effects in comparison to traditional methods. Notably, metallic nanoparticles synthesized through green chemistry utilizing biological entities, contribute to the mitigation of side effects while augmenting the metal’s efficiency against cancer cells. These environmentally friendly nanoparticles have become integral in research, demonstrating significant antimicrobial and cytotoxicity activities across diverse cancer cell lines. In this review concentrates on metal nanoparticles, specially silver and gold, synthesized via green chemistry approach. The aim is to explore their impact on inducing cancer cell death, delving into the associated molecular pathways. The primary objective of this review is to discern strategies for expediting the clinical applications of silver and gold nanoparticles based therapeutic systems. The overarching goal is to reduce normal tissue toxicity consequently elevating the overall efficacy of the treatment. Anticipated advancement in nano-medicines are poised to revolutionize future cancer treatment modalities, ushering in a paradigm shift characterized by minimal side effects and enhanced therapeutic outcomes.

Green Synthesis and Characterization of Silver Nanoparticles Derived from Ethanol Extract of Sappan Wood

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Silver nanoparticles had been synthesized through the reduction process using an ethanol extract of sappan wood (Caesalpinia sappan L.) as a bioreductor.  The variation of the formula used is a mixture of the ethanol extract of sappan wood with a 2 mM AgNO3 solution in a volume ratio of 1:1, 1:2, 1:3, and 1:4. The results showed that the UV-Visible spectrophotometry confirmed that the volume ratio of 1:1 was the optimum formula with an absorbance value of 1.243 at the maximum wavelength of 446 nm. Particle size analysis using Zetasizer Nano ZS revealed that the synthetized silver nanoparticles had a particle size of 618.1 nm. The hydroxyl group (OH) had a important role in the nanoparticle formation process, according to functional group characterization using FTIR. Due to silver nanoparticles tendency  to agglomerate, the SEM image of the silver nanoparticles showed a variety of sizes and forms.