Articles

Potential Biomarkers for Diagnosis and Prognosis of Acute Myeloid Leukemia

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For many years, cancer has affected the global population from an economic, social and political point of view and, in most cases, it is a malignant tumor with serious consequences for patients. The objective of this study is to answer the potential biomarkers for the diagnosis and prognosis of acute myeloid leukemia. Therefore, this is an exploratory, descriptive bibliographic study with a qualitative approach. The data were collected from a bibliometric survey carried out during a study of scientific production on the proposed topic from 2013 to 2023. After searching for articles, 210 articles were found on the PubMed platform, and no results were found for the key suggested by word in other databases. Among the 210 articles, 28 articles were selected for review. In this way, we seek to analyze which biomarkers have been addressed in the last 10 years in the scientific literature, thus aiming to demonstrate possible targets for new research. We divide our research into genes that are promising biomarkers for diagnosis and/or prognosis and the role of miRNAs as biomarkers.

Development of Screening Instruments for Detection of Neglect in the Elderly with Cardiovascular Disorders

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Neglect in the elderly, if not addressed, will cause serious problems, especially in the elderly who have cardiovascular problems. This study aims to develop an instrument that detects neglect of the elderly with cardiovascular disorders at home. This study uses Research and Development research design. The population is all families with elderly and elderly who experience cardiovascular disorders in the working area of the Nanggalo Health Center, Padang. Data were collected using questionnaires to the elderly families and guided interviews with the elderly. The results of the questionnaire development obtained 42 questions that can be used to detect neglect of the elderly with cardiovascular disorders at home.

Comparison of Mobility Behavior of Children from a Physical Education Kindergarten with Children from a Regular Kindergarten

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Mobility in the sense of the International Classification of Functioning, Disability and Health ICF-CY is an important prerequisite for participation in everyday life. The present study aims to show to what extent a movement promotion program in kindergarten has an effect on mobility behavior. Methods: The sample consists of 46 boys and 34 girls (age 4.51 ± .98 years) from one regular and one physical education kindergarten. The MobiScreen 4-6 was performed. Group differences were examined using a t-test, and multiple linear regression analysis was used to examine the effects of the predictors kindergarten affiliation, age, sex, born premature, sports club membership, and number of sports hours in the club. Results: Total time shows a strong multiple coefficient of R = .75 with an explained variance of R² = .57; total score also shows strong values of R = .59 and R² = .35. Age and sports club membership are the strongest predictors for both variables. Conclusions: Since raw values are analyzed for total time and score, the high influence of age is obvious. The effect of sports club membership indicates that the children may be better supported in their free time than in the concept of physical education kindergarten. Therefore, the concept of the physical education kindergarten should be reviewed and standardized.