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In this study, an analysis of the incidence of COVID–19 in the Fergana region was carried out, the number of vaccinated vaccination coverage and those who recovered after vaccination with COVID–19 was determined. The incidence was studied for the period from March 2020 to 2022. Since vaccination began in 2021, we analyzed those vaccinated and recovered from 2021 to 2022. The dynamics of the incidence of COVID–19 in the Fergana region was undulating. During the surveyed period, the intensive indicator of the incidence of COVID–19 was as follows: in the city of Fergana (887.6), Kuvasay–1169.5, Kuva–995, Sokh–737.2, Yazyavan–781, Altiarik–610.1, Fergana–472 cases per 100,000 populations. During this period, more than 7 million doses of COVID–19 vaccines were administered, and no side effects of the vaccines used were observed among those vaccinated.