Articles

Investigation of Momordica charantia phytochemicals against PIM1 Kinase: A Computational Approach

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Prostate cancer is a significant contributor to male cancer-related mortality. PIM1 kinase has implications in the development and progression of various cancers, particularly prostate cancer. PIM1, a serine/threonine protein kinase plays a crucial role in cellular processes including survival, growth and differentiation. In prostate cancer increased PIM1 expression is associated with a more aggressive phenotype and poorer patient outcomes. It has emerged as a promising therapeutic target for prostate cancer treatment. The development of PIM1 kinase inhibitors has greatly enhanced and progressed significantly. Different stages of clinical trials demonstrating their potential as therapeutic agents. Momordica charantia, or bitter melon has a long history in traditional medicine for various health conditions, it is very rich in secondary metabolites like triterpenoids, glycosides, alkaloids, flavonoids and phenolic acids. Bitter melon is considered to have medicinal properties including potential anticancer phytochemicals. This study employs virtual screening, molecular dynamic simulation and ADME/T analysis to explore bitter melon’s phytochemicals and their interaction with PIM1 kinase. The goal is to understand the molecular details and pharmacokinetics of bitter melon compounds evaluating their potential as therapeutic agents against prostate cancer. In our present study, it was found that out of all investigated phytochemicals catechin and gallic acid shows satisfactory result depending upon various parameters taken into consideration for conducting the study.

Grapes (Vitis Vitaceae) – Potent Medicinal Fruit Serves as a Source of Antioxidants and Antibacterial Agent

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In plant kingdom, medicinal plants are main important resource for a variety of drug like emetics, anti-cancer and antimicrobials. Medicinal herbs are highly cultured in India, which includes more than 2000 species are present. Grapes are soft fruit crop belongs to the Family of Vitaceae and Genus of Vitis. Grapes contain excellent source of nutritional values such as vitamins, minerals, proteins and carbohydrate. In this present work, various phytochemical constituents of grapes were identified in different extracts (Ethanol, Acetone and Aqueous). These phytochemicals are used for the treatment of several diseases. The antioxidant property of different extracts of grapes shows better result. The ellagic acid and the natural phenolic antioxidants were also identified. The antimicrobial activity of various grapes extract shows better result against Enterococcus and E.coli sps. Finally, the grape fruit is a wonderful antioxidant and antimicrobial agent.