Articles

The Effectiveness of Moringa Leaf Extract Ointment (Moringa oleifera lam) In the Healing Process of Incision Wounds in Mice (Mus musculus)

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Background: Wounds are a form of damage or loss of tissue in the body. The use of both modern and traditional medicines in wound healing itself aims to speed up the healing process. One of the traditional plants that can be used as medicine is moringa leaf (moringa oleifera lam).
Objective: The aim of this study is to knowing the effectiveness of moringa leaf extract ointment (moringa oleifera lam) in the healing process of incision wounds in mice (mus musculus). Methods: This study uses a true experiment design research design with a post test control group. The sampling technique is using purposive quota sampling and sample grouping by randomization. Samples divided into 4 groups consisted of aquades group, moringa leaf extract ointment group 5%, 10%, and 15%. The wound healing was valuation by measuring the length of the wound using a caliper and macroscopic observation of fibroblast growth. The study analysed in univariate and bivariate by Kruskal-Wallis test and continued with post hoc LSD test.
Result: Bivariate analysis result shows there is a significant difference of giving moringa leaf extract ointment (moringa oleifera lam) to the length of closing of the mice incision wound (Mus musculus) with significance value p < 0,05 on the 3rd day (p= 0,001) and 7th (p = 0,000). The results of the stung number of fibroblasts showed that Moringa leaf extract ointment with a concentration of 5% had the largest increase in the number of fibroblasts compared to other groups.
Conclusion: There is a significant difference effect of giving moringa leaf extract ointment (moringa oleifera lam) on the healing process of incision wounds in mice (mus musculus) with a concentration of 5%.

Nutrient Content of Pig Feed Based Local Feed Mixed with Liquid Fermentation Products from Moringa and Azadirachta indica Leaf Extracts

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This research aims to determine the nutritional content of rations based on local feed mixed with liquid Moringa leaf extract and fermented Azadirachta indica as pig feed. The research materials used were Moringa leaves and Azadirachta indica which were extracted and liquid fermented as well as local rations. In this study, an experimental method was used with a completely randomized design consisting of 5 treatments and 4 replications. The treatment in this study was R0; ration without liquid fermented extract, R1; ration + 10% liquid fermented extract, R2; ration + 20% liquid fermented extract, R3; ration + 30% liquid fermented extract, R4; ration + 40% liquid fermented extract. The data obtained were analyzed using analysis of variance. Based on the research results, the crude protein content (%) R0; 13.90±0.40, R1; 15.02±0.12, R2; 17.73±0.88, R3; 19.20±0.29, R4; 20.22±0.41, crude fiber content (%) R0; 7.10±0.18, R1; 6.90±0.27, R2; 6.85±0.39, R3; 7.08± 0.17, R4; 7.04±0.14, non nitrogen free extract content (%) R0; 48.69±1.88, R1; 49.42±0.48, R2; 47.54±0.79, R3; 46.14±0 .79, R4; 45.34±0.72, gross energy content (kcal), R0; 3524±45.55, R1; 3620±26.77, R2; 3698±19.24, R3; 3742±10.88, R4; 3770±31, 28. The results of statistical analysis showed that the treatment had a significant effect of P<0.05 on crude protein, non nitrogen free extract, energy content, but had no significant effect of P>0.05 on crude fiber content. The conclusion of this research is that the addition of fermented Moringa leaf extract and Azadirachta indica liquid to local pig rations has an effect on increasing protein and energy content with an average increase in protein content of 3.36% and energy of 107.73 kcal. for each increase, add 250 ml of liquid Moringa leaf extract and fermented Azadirachta indica to the local ration.

The Concentrations of Cholesterol and Reproduction Hormones in Serum of Rabbits Doe That Consumed Moringa oleifera Leaf Extracts

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This study was conducted to examine the effect of various kinds of Moringa leaf extracts on cholesterol, estradiol, FSH, LH levels and litter size in rabbit does. The extracts used were hexane fraction extract (HeEF), ethanol fraction extract (EtEF) and ethanol rough extract (EtCE) from moringa leaf flour. Seven treatments were administered including extracts in pellets at a dose of 0, 0.13% HeEF, 0.26% HeEF, 0.37 EtEF, 0.74% EtEF, 0.54% EtCE and 1.08% EtCE. Each treatment was reduplicated on 4 rabbits. Cholesterol levels, estradiol, LH and FSH blood serum, mating readiness and litter size were measured, which results showed that the treatment significantly (P <5%) lowered the cholesterol level and increased the estradiol level in blood serum. On the other hand, the treatment had no significant effect on FSH, LH and litter size levels except at LH levels 2 hours after mating.