Articles

Correlation between Coagulation Profile and Blood group among patients with Ischemic Heart Disease in Khartoum State

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Background: Coronary artery disease (CAD), also known as ischemic heart disease (IHD) is a group of diseases that includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death. It’s considered a major public health issue that affects an estimated 1 in 3 adults in the United States. The ABO blood group and coagulation profile exerts a profound influence on hemostasis,

This study was aimed to correlate between ABO grouping & coagulation profile in Ischemic heart disease at Khartoum State.

Methods: This was case and control study conducted during the period from January to May 2021 at Ahmed gasim hospital. Study included hundred (100) sample, fifty (50) Ischemic heart disease (IHD) patients taken as cases and fifty (50) apparently healthy taken as controls. Blood samples were collected for the analysis of prothrombin time (PT), activated partial thromboplastin time (aPTT) using STart stago semi-automated instruments and for the determining the ABO blood group using direct slide agglutination method. Statistical analysis was performed using SPSS version 25.

Results: The results of study showed that the most frequent ABO blood type among all the participants among ischemic and healthy individuals was O. The mean level of APTT in Ischemic Heart Disease (IHD) showed that there was significantly decreased (27.06 ± 3.04) when compared to control group (29.45 ± 3.7) with p. value 0.001. However no significance differences in the mean level of PT between two groups (p value= 0.96).

Its also observed that among all study participants, in blood group A, the PT and aPTT levels were the least, while blood group O had the greatest PT and aPTT values. No association was found between ABO grouping and coagulation profile in ischemic heart disease in case and control group.

Conclusion: This study concluded that O blood group was more frequent among patients with IHD followed by A blood group and least frequent was AB. In addition, there was significant shorter aPTT in Ischemic Heart Disease cases when compared to control group.

No association was found between ABO grouping and coagulation profile in ischemic heart disease in case and control group.

Prevalence of Coronary Heart Disease (CHD) and Selected Risk Factors of CHD, Among People Aged 30-64 Years in the District of Gampaha, Sri Lanka

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Background- Coronary heart disease (CHD) is the leading cause of hospital deaths in Sri Lanka. The underlying risk factors include; tobacco smoking, unhealthy diet, harmful alcohol use, physical inactivity, and medical conditions; hypertension, diabetes mellitus, obesity, dyslipidaemia. Objective of this study was to determine prevalence of CHD and risk factors among people aged 30-64 in Gampaha District, Sri Lanka.
Methods- A community based cross-sectional study was conducted among 1192 people aged 30-64 years in district of Gampaha, recruited by probability proportionate to the population size, cluster sampling. Data were collected using a pre-tested interviewer-administered questionnaire on prevalence of CHD, hypertension, diabetes mellitus, dyslipidaemia, obesity, harmful alcohol use, unhealthy diet, physical inactivity and tobacco smoking and anthropometric measurements by trained data collectors. Twelve-lead ECG, blood pressure, fasting plasma glucose and lipid levels were done for previously undiagnosed. Data were analyzed using SPSS-21.
Results- The estimated prevalence of CHD based on already diagnosed cases and Rose positive angina 6.9% (95% CI 5.4% – 8.4%), CHD based on already diagnosed cases and ECG 6.4 (95% CI 4.9% – 7.8%), hypertension 37.5% (95% CI 34.7% to 40.3%), diabetes mellitus 17.4% (95% CI 15.2% to 19.6%), dyslipidaemia 66.5% (95% CI 63.8% – 69.2%). The estimated prevalence of other modifiable risk factors of generalized obesity (BMI≥25.0) (44.0%, 95%CI41.1-46.9), sub-optimal quality diet (71.9%, 95%CI 69.3-74.5), low level of physical activity (21.7%, 95%CI 19.3-24.1), heavy or high-risk drinking 11.4% (95%CI 9.56-13.2), smoking 14.2% (95%CI 12.2-16.2).
Conclusions- Estimated prevalence of CHD and selected risk factors were high in Gampaha District with a large proportion of previously undiagnosed disease. Immediate public health action is needed including training programs for healthcare workers on detection of risk factors and awareness among the public for screening for risk factors.