Articles

Culture of Human Behavior in Architecture

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The basic process that involves human interaction with their environment is environmental information obtained by the process of perception. Perception is formed because of the interaction of a person (individual) with their life space, which is finally realised in behavioral attitudes. Thus, the behavior, response, and action are determined by personal perception. It can be argued that human psychiatry determines human behavior in the form of condition, attitude, perception, cognition, and motivation. Cognition is obtained from the culture, experience, and education that an individual owns. The aspect of cognition is an aspect of change movement because the information received determines the feeling and the willingness to do. In terms of cognition, it consists of several components, namely cognitive components that will answer the question of what people think about objects. The components of affection conation will answer what is felt (happy / not happy) to the object, and it will answer the question of the willingness to act toward the object. Each component does not stand alone, but one unity is called the cognition system. The cognition system is the result of a cognitive process. It comprises perception activities, imagination, thinking, reasoning, and decision-making.

Protective Effect of Selenium against Methotrexate Induced Hepatotoxicity

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Introduction: The liver is the largest internal organ by percent weight in the human body and has crucial functions, including cholesterol production, intermediary metabolism, hormone synthesis, bile and urea production and drug detoxification.
Objectives: The main objective of the study is to analyse the Protective effect of selenium against methotrexate induced hepatotoxicity in mice.
Material and methods: This descriptive study was conducted in Jinnah Hospital Lahore during 2020. Selenium and all chemical reagents of analytical grades were purchased from Sigma Chemical Co. (St. Louis, Mo, USA). The dose of MTX diluted in water (50% 1ml/kg of body weight of Mice were applied twice a week for six weeks to induced hepatocellular injury determined by liver function tests. The mice were maintained under pathogen-free conditions with air conditioning, a 12-hr light/12-hr dark cycle, and %55 humidity.
Results: Results shows that a significant increase in serum enzymes (ALT, AST, ALP) and significant decrease in total protein was observed in all groups receiving MTX for the induction of hepatic injury. Mice receiving combination therapy of selenium along with MTX shows a time course recovery towards normalcy. The highest value of ALT (94.83 IU/L), AST (73.21 IU/L) and ALP (157 IU/L) were recorded in Mice receiving MTX for hepatic injury. The lowest values (63.67, 51.49 and 139.95 IU/L) was recorded in group treated with MTX+ Se (200mg/kg b.w) but both the groups differed non significantly and shows the same trend but a decreasing trend in serum enzymes (ALT 32.85%), (AST 29.67%) and (ALP 11.40%).
Conclusion: It is concluded that selenium supplementation in MTX treated rats elicited a reduction in the toxic effects of the pesticide by improving the studied parameters, which was confirmed by the biochemical analysis of serum.