Articles

The Peculiarities of the Development of the Composition and Technology of the “Sedtab” Tablet

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Today, neurological diseases occupy one of the leading places in terms of prevalence among all diseases. According to the World Health Organization, over the past 65 years, the number of neurological diseases in the world has increased more than 20 times and amounts to approximately 40%. Despite the relatively wide availability of means for the prevention and treatment of neurological diseases, the development and implementation of new, more effective and safe means remains relevant. In this regard, preparations from medicinal plants deserve special attention, since they are closer to the human body than synthetic drugs, easily enter into metabolic processes, practically do not cause side effects and often reduce negative consequences.

The main goal of this work is to develop a new composition and technology for “Sedtab” tablets based on local plant materials, i.e. stinging nettle, lemon balm and motherwort, as well as the study of technological properties based on scientific criteria for the creation of medicinal products.

The Determination of Mycotoxins in the Composition of Walnut (Juglans Regia L.) Fruits Cultivated in Different Geographical Regions of Uzbekistan by High–Performance Liquid Chromatography Method and Their Comparative Analysis

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Mycotoxins are secondary metabolites produced by various fungi and are known to have significant adverse effects on human and animal health. If food products are contaminated with mycotoxins, their toxicity can cause various diseases. In this scientific research work, residual mycotoxins in nutrients were combined with liquid–liquid extraction (LLE) and analyzed through the use of reversed–phase high–performance liquid chromatography (RP–HPLC). These scientific studies were conducted in the experimental biology laboratory of Gulistan State University to determine the amount of aflatoxin (AFB2, AFG1, AFG2) in the samples of walnuts cultivated in six regions of Uzbekistan. The study revealed the detection of aflatoxins AFG1 type 0.003 in the designated region labeled as S20, AFB2 and AFG2 0.001 in J25, and AFG2 0.002 in S30. However, it is important to note that these levels did not above the maximum residue level standards established by the Republic of Uzbekistan. However, the aflatoxins produced by fungi are released based on the development of fungi at a temperature of 25–3000C, therefore it is recommended to store walnut fruits in dry conditions at a temperature of 1500C. All the methods used during scientific analysis can demonstrate high sensitivity and accuracy. All methods are successfully used to identify mycotoxins in the composition of walnut fruits, separate them from fungi and specify the amount of ingredients.

Study of the Properties of the Composition Obtained Based on Mixtures of Polyvinyl Chloride and Ethylene-Propylene Copolymers

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The properties of mixtures and vulcanizates of polyvinyl chloride (PVC) and ethylene-propylene elastomers (SKEPT-40) with functional group polymers have been studied and it appears that the effectiveness of the application of functional group polymers (FQP) is characterized by the improvement of the complex properties of vulcanizates. As shown, among the FQP, the industrial scale production of PVC and the low cost of its use in the purchase of rubber mixtures based on SKEPT have been developed. In this regard, new composition mixtures were obtained by replacing the main polymers in rubber mixtures with 5÷30 mass parts of PVC based on SKEPT. The physical and mechanical properties of their technological and vulcanizates were studied. Experiments show that the sol-fraction and durability of vulcanizate in gasoline, gasoline-benzene (3:1) mixture, and metaxylol decrease with the increase of PVC content.

The reduction of the sol-fraction of the vulcanizate can be explained by the low swelling of PVC in the above-mentioned solvents. Therefore, the vulcanizate based on the SKEPT PVC mixture has a higher resistance to oil and gasoline than the vulcanizate based on unmodified SKEPT. It is learned that 10 mass. h to SKEPT. When PVC is included, the degree of swelling of the vulcanizate is reduced by 20% in gasoline, in the mixture of gasoline-benzene (3:1), M-xylene, and “, Avtol” oil, compared to the vulcanizate based on SKEPT. 30 c.h. and when included, the degree of swelling of the vulcanizate decreases by 2.7 times in gasoline, 2.3 times in gasoline-benzene (3:1) mixture, and 3.2 times in “Avtol-10” oil.