Articles

Potential Biomarkers for Diagnosis and Prognosis of Acute Myeloid Leukemia

/in /by

For many years, cancer has affected the global population from an economic, social and political point of view and, in most cases, it is a malignant tumor with serious consequences for patients. The objective of this study is to answer the potential biomarkers for the diagnosis and prognosis of acute myeloid leukemia. Therefore, this is an exploratory, descriptive bibliographic study with a qualitative approach. The data were collected from a bibliometric survey carried out during a study of scientific production on the proposed topic from 2013 to 2023. After searching for articles, 210 articles were found on the PubMed platform, and no results were found for the key suggested by word in other databases. Among the 210 articles, 28 articles were selected for review. In this way, we seek to analyze which biomarkers have been addressed in the last 10 years in the scientific literature, thus aiming to demonstrate possible targets for new research. We divide our research into genes that are promising biomarkers for diagnosis and/or prognosis and the role of miRNAs as biomarkers.

Biochemical Influence of Uric Acid and Some Inflammatory Biomarkers on the Association of Oral Hygiene with Cardiovascular Diseases

/in /by

Oral hygiene was associated with cardiovascular diseases (CVD), and the link is verified by bacterial colonization of the oral cavity and their products that spread into the circulation, starting endothelial dysfunction, pro-atherogenesis, pro-inflammation, and host immune mechanisms. High levels of serum uric acids are linked with CVD that are intern, associated with worsening gum hygiene. Several studies show that hyperuricemia could modify purine catabolism in case of oral disorders, including periodontal diseases (PD) and dental loss. PD and tooth caries were also linked with diabetes mellitus hypertension, insulin resistance, metabolic syndrome, dyslipidemia, and CVD. Dental caries was defined as an independent risk factor for coronary atherosclerosis too. However, dental restoration was correlated with the burden of arteriosclerosis negatively. Several experimental trials did not affirm the relationship between oral hygiene and CVDs.

Recent research has revealed similar biochemical and inflammatory biomarkers that are involved in CVD and oral diseases like C-reactive protein, interleukins, TNF-α, and others.

This consensus review aims to summarize some of the biochemical and inflammatory evidence connecting poor oral hygiene with the risk of CVD.