Tag Archive for: Antenatal Check-up

Introduction: APLA have been associated with a number of obstetric complications however their  role  in  the  pathogenesis  of  preeclampsia  has  remained  an  issue  of controversy. There is a lack of information on APLA in pre-eclamptic women.

Objective: To assess the association between antiphospholipid antibodies (APLA) and preeclampsia (PE) in females presenting for antenatal check-up.

Materials and Methods: This Case Control study was conducted in Services Institute of Lahore. After approval from hospital ethical committee, 200 females, fulfilling the inclusion criteria were included in the study from OPD of Department of Obstetrics & Gynecology. Informed consent was obtained. Demographic information was also recorded. The females were divided in two groups on the basis of presence or absence of PE i.e. cases and controls.

Results: The mean age of the patients among cases was 27.60±4.96 years the minimum age was 20 years and maximum was 35 years whereas among controls the mean age of the patients was  27.94±4.13 years the minimum age was 20 years and maximum was 35 years .The mean gestational age among cases was 27.46± 4.72 weeks the minimum gestational age was 20 weeks and maximum was 35 weeks on the other side the mean gestational age among controls was 27.25± 4.74 weeks the minimum gestational age was 20 weeks the maximum was 35 weeks. There was significant association between preeclampsia and APLA as the p-value was significant (p-value=0.007).

Conclusion: Results of this study showed a significant association and significant risk between APLA and preeclampsia. Therefore a routine assay of APLA in women at  risk  of  preeclampsia should be done. However  APLA  testing  should  be  considered  in  women  with  early  onset  severe  preeclampsia,  especially  when  additional  clinical features of APS are present.