Abstract :

The present study has been undertaken with the aim to formulate and evaluate the new polyherbal gel formulation containing 0.3 % hydroalcoholic  extract from Trigonellafoenum-graecum and Glycyrrhiza glabra for its topical anti inflammatory activity against carrageenan induced rat paw edema method .The studies were conducted on Wistar rats of either sex (150-180g).The polyherbal gel formulation was designed by using Carbopol 934, SodiumCMC, Trigonellafoenum-graecum, Glycyrrhizaglabra  extract, Ethanol, propylene glycol 400,  methyl paraben, propyl paraben, and required amount of distilled water. The skin ph (6.8-7) was maintained by drop wise addition of tri- ethanolamine. The prepared polyherbal gels were evaluated for physical appearance, pH, spreadability, skin irritation to observe side effect. It was inferred from the results that polyherbal gel formulations were good in appearance and homogeneity. The overall result of this research the prepared poly herbal gel formulation shows significant anti-inflammatory activity.

---

Keywords :

Anti inflammatory, Carbopol934, Glycyrrhizaglabraand Poly herbal gel, Trigonellafoenum-graecum.

---

References :

1. Norris DA. Mechanisms of action of topical therapies and the rationale for combination therapy. J Am Acad Dermatol 2005;53:17-25.
2. Uche DOV. Sol-gel technique: A veritable tool for crystal growth. AdvApplSci Res 2013;4:506-10.
3. Khandelwal K.R. Practical pharmacognosy Techniques and experiments. 9^thPune,NiraliPrakashan;2002: 149-160.
4. Rababah TM, Hettiarachchy NS, Horax R. Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tertbutyl hydroquinone. J Agric Food Chem 2004;52:5183-6.
5. Dixit P, Ghaskadbi S, Mohan H, Devasagayam TPA. Antioxidant properties of germinated fenugreek seed.Phytother Res 2005;19:977-83.
6. Shang M, Cai S, Han J, Li J, Zhao Y, Zheng J, et al. Studies on flavonoids from fenugreek (Trigonellafoenumgraecum). ZhongguoZhongyaoZazhi 1998;23:614-16.
7. Pharmacognsy and Phytochemistry.CareerPublication. 2000;2:225, 257.
8. KulkarniP,KewatkarS,LandeM,PhanseMandChaudhariP.Topicalanti Inflammatoryactivityofherbalgelformulation.SRLDPC.2010;2(3):338-342.
9. ScreeningmethodsofPharmacology,AcademicPressLondon,1965;152
10. AyurvedicPharmacopoeia,1^stGovernmentofIndia.MinistryofhealthandfamilywelfaredepartmentofAyurveda,YogaandNaturopathy,Unani,SiddhaandHomoeopathy,NewDelhi,2007;3:25-26.
11. http://en.wiki/inflammation.
12. Vogel HG. Drug Discovery and Evaluation Pharmacological assay. Springer Publication. 2008; 2: 1110.Winter C.The SearchforAnti-inflammatoryActivity,Rheumatism.1982;2(1):1982.
13. Indian herbal pharmacopoeia.Drug manufacture association. 2002;106:272.