Abstract :

Obesity is a disease in which excess accumulation of fat occurs in the adipose tissues of the body. Obesity is the main cause of many diseases such as type- 2 diabetes, cardiovascular diseases, and mental health disorders such as depression.  In recent studies, Moringa oleifera have been found to have antilipidemic activity by reducing the levels of total cholesterol, triglycerides and low density lipoprotein. This review compares the therapeutic effect of herbal drug to orlistat, a lipase inhibitor. The mechanism of action of Orlistat is to prevent the intestinal absorption of fat present in food resulting into excretion of the unabsorbed fat from the body in the stool.

---

Keywords :

anti-obesity, appetite suppressant, lipid profile, M. oleifera leaves., Obesity

---

References :

1. Yun, 2010, WHO, 2015
2. Vaidya, 2006, Oussaada et al., 2019
3. Fock and Khoo, 2013, Sasaki et al., 2014, Oussaada et al., 2019
4. McArdle et al., 2013, Tanti et al., 2013, Jung and Choi, 2014, Wu and Ballantyne, 2020
5. Jarolimova et al., 2013, Apovian, 2016
6. Kang and Park, 2012, Cheung et al., 2013
7. Yun, 2010, Kang and Park, 2012, Cheung et al., 2013
8. Rahman et al., 2017, Arika et al., 2019
9. Gamboa-Gómez et al., 2015
10. Konstantinidi & Koutelidakis, 2019
11. Dehghani and Alizadeh, 2016, Gopalakrishnan et al., 2016
12. Singh et al., 2020
13. Mirhashemi, Mohseni, Hasanzadeh, & Pishvaee, 2018
14. Daghaghele et al., 2021, Mehwish et al., 2021, Xiong et al., 2021
15. Kim et al., 2020, Muhammad et al., 2020
16. Waterman et al., 2015
17. Bhattacharya, Tiwari, Sahu, & Kumar, 2018
18. Abd Rani, Husain, & Kumolosasi, 2018
19. Balusamy et al., 2019, Kim et al., 2020, Muni Swamy et al., 2020
20. Guerciolini R. Mode of action of orlistat. Int J Obes Relat Metab Disord. 1997 Jun;21 Suppl 3:S12-23. [PubMed]
21. Aborehab et al., 2016, Xie et al., 2018
22. Ali A., Boutjdir M., Aromolaran A.S. Cardiolipotoxicity, inflammation, and arrhythmias: Role for interleukin-6 molecular mechanisms. Physiol. 2018;9:1866. doi: 10.3389/fphys.2018.01866. [PMC free article][PubMed] [CrossRef] [Google Scholar]

23. Sawmy & Meriga, 2020
24. Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP, Elisaf MS. Orlistat-associated adverse effects and drug interactions: a critical review. Drug Saf. 2008;31(1):53-65. [PubMed]
25. Humayun Y, Ball KC, Lewin JR, Lerant AA, Fülöp T. Acute oxalate nephropathy associated with orlistat. J Nephropathol. 2016 Apr;5(2):79-83. [PMC free article] [PubMed]
26. McDuffie JR, Calis KA, Booth SL, Uwaifo GI, Yanovski JA. Effects of orlistat on fat-soluble vitamins in obese adolescents. 2002 Jul;22(7):814-22. [PubMed]
27. J. Asiedu-Gyekye, S. Frimpong-Manso, C. Awortwe, D.A. Antwi, A.K. Nyarko Micro-and macroelemental composition and safety evaluation of the nutraceutical Moringa oleiferaleaves J. Toxicol., 2014 (2014), pp. 1-13