Abstract :
An increase in the population of patients with diabetes mellitus affects the incidence of diabetic foot syndrome (DFS), as its chronic complication. Among the various types of growth factors that play a role in the development of late complications of diabetes, vascular endothelial growth factor, VEGF, is currently in the focus of attention. The study conducted by the authors was aimed at determining the relationship between the G634C polymorphism of the VEGFA rs2010963 gene and the predisposition to the development of diabetic foot syndrome in patients with diabetes mellitus. We examined 96 patients aged 39 to 76 years with diabetes mellitus complicated by diabetic foot syndrome. Based on the studies, it was determined that the G634C polymorphism in the VEGFA gene (rs2010963) is involved in the formation and development of diabetic foot syndrome in patients with diabetes mellitus.
Keywords :
diabetes mellitus, Diabetic foot, Genetic polymorphism, Vascular endothelial growth factorReferences :
- Al–Lawati J.A. // Diabetes mellitus: A local and global public health emergency! –Oman Med J. Vol. 32 (3), 2017. – p. 177–179. https://doi. org/10.5001/omj.2017.34.
- Trikkalinou A., Papazafiropoulou A.K., Melidonis A. // Type 2 diabetes and quality of life. World J Diabetes. №8 (4), 2017. – p. 120–129. https://doi.org/10.4239/wjd.v8.i4 .120.
- Li X., Lu Y., Wei P. // Association between VEGF genetic variants and diabetic foot ulcer in Chinese Han population. Medicine (Baltimore). Vol. 97 (20), 2018. https://doi.o rg/10.1097/ MD.0000000000010672 PMid:29768333.
- Armstrong D.G., Boulton A.J., Bus S.A. // Diabetic foot ulcers and their recurrence. N Engl J Med. Vol. 376, 2017. – p. 2367-2375. https://doi. org/10.1056/nejmra1615439.
- Amoli M.M., Hasani–Ranjbar S. et all. // VEGF gene polymorphism association with diabetic foot ulcer. Diabetes Res Clin Pract. Vol. 93 (2), 2011. – p. 215–219. https://doi. org/10.1016/j.diabres.2011.04.016.
- Qin Z., Fang W. et all. // VEGF levels in plasma in relation to metabolic control, inflammation, and microvascular complications in type–2 diabetes: A cohort study. Medicine (Baltimore). Vol. 97 (15), 2018. https://doi.org/10.1097/MD.00000000000104 15.
- Ruthenborg R.J., Ban J.J. et all. // Regulation of wound healing and fibrosis by hypoxia and hypoxia–inducible factor–1. Mol Cells. Vol.37 (9), 2014. – p. 637–643. https://doi:10.14348/molcells.2014.0150.
- Bowers S.L., Kemp S.S. et all. // Defining an upstream VEGF (vascular endothelial growth factor) priming signature for downstream factor–induced endothelial cell–pericyte tube network coassembly. Arterioscler Thromb Vasc Biol. Vol. 40, 2020. – p. 2891. https://doi.org/10.1161/ ATVBAHA.120.314517.
- Imoukhuede P.I., Popel A.S. // Expression of VEGF receptors on endothelial cells in mouse skeletal muscle. PLoS One. Vol. 7 (9), 2012. https://doi.org/10.1371/journal.pon e.0044791.
- Kivela R. et al. // Endothelial cells regulate physiological cardiomyocite growth via VEGFR2–mediated paracrine signaling. Circulation. Vol. 139, 2019. – p. 2570–2584. https://doi. org/10.1161/circulationaha.118.036099.
- Liao X.H. et al. // VEGF–A stimulates STAT3 activity via nitrosylation of myocardin to regulate the expression of vascular smooth muscle cell differentiation markers. Sci Rep. Vol. 7 (1), 2017. https://doi. org/10.1038/s41598–017–02907–6.
- Chen Y. et al. // Physiological electric field works via the VEGF receptor to stimulate neovessel formation of vascular endothelial cells in a 3D environment. Biol Open. №7 (9), 2018. https://doi.org/10.1242/bio.035204.
- Ramakrishnan S., Anand V., Roy S. // Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol. №9 (2), 2014. – p. 142–160. https://doi.org/10.1007/s11481–014–9531–7.
- Morfoisse F. et all. // Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis. Mol Cell Oncol. №1 (1), 2014. https:// doi.org/10.4161/mco.29907.
- Semadi N.I. // The role of VEGF and TNF–alpha on epithelialization of diabetic foot ulcers after hyperbaric oxygen therapy. Open Access Maced J Med Sci. №7 (19), 2019. – p. 3177–3183. https://doi. org/10.3889/oamjms.2019.297.
- Zhang J. et all. // Increased growth factors play a role in wound healing promoted by noninvasive oxygen–ozone therapy in diabetic patients with foot ulcers. Oxid Med Cell Longev, 2014. https://doi. org/10.1155/2014/273475.
- Caley M.P. et all. // Metalloproteinases and wound healing. Adv Wound Care (New Rochelle). №4 (4), 2015. – p. 225–234. https://doi.org/10.1089/wound.2014.0581.
- Rousselle P., Beck K. // Laminin 332 processing impacts cellular impacts cellular behavior. Cell Adh Migr. 2013. – p. 122–134. https://doi.org/10.4161/cam.23132.