Abstract :

Undenatured type II collagen (UC-II) is supplementary which is from chicken sternum cartilage. (Lugo, J. P., Saiyed,…,2015) UC-II has undenatured type II collagen componentand. The safety and capability of UC-II in adjusting joint discomfort in Osteoarthritis and Rheumatoid arthritis support by previous preclinical and clinical studies. (Lugo, J. P., Saiyed,…,2013) Osteoarthritis (OA) is atrophy joint disease affecting the quality of life of the elderly population. A lot of evidence that nutraceuticals from natural herbs may play essential part in inflammation and joint catastrophe in OA. Moreover, various studies these supplements have been found to be proficient in OA. None of these supplements have reported side effects. However, questions connected to their capability and safety for OA prevention and treatment is quality trials are needed to give absolute answers. (Vaishya, R., Agarwal,…,2018)

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Keywords :

osteoarthritis (OA), rheumatoid arthritis (RA), supplement, Treatment., undenatured type II collagen (UC-II)

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References :

1. Lugo, J. P., Saiyed, Z. M., & Lane, N. E. (2015). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition journal, 15(1), 1-15.
2. Lugo, J. P., Saiyed, Z. M., Lau, F. C., Molina, J. P. L., Pakdaman, M. N., Shamie, A. N., & Udani, J. K. (2013). Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition, 10(1), 48.
3. Vaishya, R., Agarwal, A. K., Shah, A., Vijay, V., & Vaish, A. (2018). Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India. Journal of clinical orthopaedics and trauma, 9(4), 338-348.
4. Harris, R. B., Fonseca, F. L. A., Sharp, M. H., & Ottinger, C. R. (2021). Functional Characterization of Undenatured Type II Collagen Supplements: Are They Interchangeable?. Journal of Dietary Supplements, 1-16.
5. Bagchi, D., Misner, B., Bagchi, M., Kothari, S. C., Downs, B. W., Fafard, R. D., & Preuss, H. G. (2002). Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. International journal of clinical pharmacology research, 22(3-4), 101-110.
6. d’Altilio, M., Peal, A., Alvey, M., Simms, C., Curtsinger, A., Gupta, R. C., … & Bagchi, D. (2007). Therapeutic efficacy and safety of undenatured type II collagen singly or in combination with glucosamine and chondroitin in arthritic dogs. Toxicology mechanisms and methods, 17(4), 189-196.
7. Bagi, C. M., Berryman, E. R., Teo, S., & Lane, N. E. (2017). Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis and cartilage, 25(12), 2080-2090.
8. Gupta, R. C., Canerdy, T. D., Skaggs, P., Stocker, A., Zyrkowski, G., Burke, R., … & Bagchi, D. (2009). Therapeutic efficacy of undenatured type‐II collagen (UC‐II) in comparison to glucosamine and chondroitin in arthritic horses 1. Journal of veterinary pharmacology and therapeutics, 32(6), 577-584.
9. Schön, C., Knaub, K., Alt, W., Durkee, S., Saiyed, Z., & Juturu, V. (2022). UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of Integrative and Complementary Medicine.
10. Gencoglu, H., Orhan, C., Sahin, E., & Sahin, K. (2020). Undenatured type II collagen (UC-II) in joint health and disease: a review on the current knowledge of companion animals. Animals, 10(4), 697.