Title : Spectrum of 25 (OH) D3 Status in Urinary Tract Stone Formers in North-Eastern Nigeria

Vol 5 No 6 (2022): Volume 05 Issue 06 June 2022

Article Date Published : 3 June 2022 | Page No.: 1839-1849 | Google Scholar | Crossref doi for this article

Abstract :

Many studies, none in northeastern part of Nigeria, investigated the association between serum/plasma vitamin D and nephrolithiasis, with no consistent result, couple with the hot weather (as high as 44oC) in most part of the year in Maiduguri and its surroundings, and assay of vitamin D today is not yet part of evaluation of urinary stone formers in Maiduguri, warrant this study to assess status of vitamin D in urinary tract stone formers in Maiduguri. Patients diagnosed with urinary tract stone disease attending Urology Clinic, University of Maiduguri Teaching Hospital and consented were recruited. The first two who consented were recruited per week for a period of 24 months (1st April 2017 to 31st Match 2019) to cover the seasonal changes in weather for the year. Serum for vitamin D is stored at -20oC for batch analysis. Vitamin D was assayed by ELISA technique (Accu-Bind, 100 North Pointe Drive, Lake Forest, California 92630 USA), other parameters were analyzed weekly using autoanalyzer (Cobas C311, ISN, Roche, Germany). Result indicated 58 (36.2%) of patients had Vitamin D values below the optimal level either having deficiency/insufficiency. Forty-nine (30.6%) showed vitamin D concentration above the optimum level out of which 4 (2.5%) had hypervitaminosis D, while 53 (33.1%) patients had optimal vitamin D values. It showed 17 (10.6%) of patients had hypercalcaemia, however, out of the 114 patients with normocalcaemia, 42 (36.5%) had their values at the upper limit of normal (2.6 mmol/L). It also indicated that though 3 of the hypercalcaemic patients had vitamin D insufficiency, majority (14) are either having optimal level or above optimal vitamin D level. Excessive and prolong exposure to ultraviolet sunlight resulting in raised vitamin D synthesis and action is an important factor associated with urinary tract stone formation in this environment cannot be excluded. The high prevalence of hypercalcaemia in the study cannot be accounted for by raised vitamin D alone, therefore measurement of serum vitamin D (25(OH)D) and PTH in evaluation of urinary tract stone formers in this environment is recommended.

Keywords :

Maiduguri, North-eastern Nigeria, Urinary tract stone disease, Vitamin D3 status.

References :

  1. Stamatelou KK, Francis ME, Jones CA, et al. Time trends in reported prevalence of kidney stones in the United States: 1976-1994. Kidney Int 2003; 63:1817-1823
  2. Scales CD, Smith AC, Hanley JM, Saigal CS. Prevalence of kidney stones in the United State. Eur Urol 2012; 62:160-165
  3. Davie, SOA, Endeley EML, Danniya MH. Urolithiasis in Maiduguri: The Nigerian Savannah belt Experience. West Afri J Med. 1988; 7:18-161
  4. Esho JO. Experience with urinary calculus disease in Nigeria as seen at Lagos University Teaching Hospital. Nig Med J 1976; 1:18-22
  5. Osegbe DN. The rise in urolithiasis in Nigeria. BMJ 1987; 295:1654
  6. Osegbe DN. Urolithiasis in Urbanized Nigerians. Nig J Surg 1994; 1:51-56
  7. Skolarikos A, Straub M, Knoll T, Sarica K, Seitz C, Petrik A, Turk C. Metabolic evaluation and recurrence prevention for urinary stone patients: Eua guidelines. Eur Urol 2015;67:750-763
  8. Sigurjonsdottir VK, Runolfsdottir HL, Indridason OS, Palsson R, Edvardsson VO. Impact of nephrolithiasis on kidney function. BMC Nephrol 2015;16:149
  9. Alexander RT, Hemmelgam BR Wiebe N, Bello A, Morgan C, Samuel S, Klarenback SW, Curhan GC, Tonelli MA. Kidney stones and kidney function loss: A cohort study. Br Med J 2012;345:5287
  10. Pearle MS, Antonelli JA, Lotan Y. Urinary lithiasis: Etiology, epidemiology, and In Campbell-Walsh Urology, 11th ed; Wein AJ, KKavoussi LR, Partin, AW, Peters AC; Eds; Elsevier: Philadelphia, PA, USA, 2016; Volume 2, pp. 1170-1199
  11. DS Mshelia, BM Gali, HU Na’aya, SA Habu. Chemical composition of urinary calculi in Maiduguri. Afri J Med med Sci 2005;34:185-188
  12. Gray RW, Wilz DR, Caldas AE, Lemann J Jr. The importance of phosphate in regulating plasma 1,25-(OH)-vitamin D levels in humans: Studies in healthy subjects in calcium-stone formers and in patients with primary hyperparathyroidism. J Clin Endocrinol Metab 1977; 45: 299-306
  13. Caldas AE, Gray RW, Lemann J Jr. The simultaneous measurement of vitamin D metabolites in plasma: Studies in healthy adults and in patients with calcium nephrolithiasis. J Lab Clin Med 1978;91:840-849
  14. Wiechhselbaum TE. Analysis of total protein in Biuret method. Amer J Clin Path 1946; 16:40-48
  15. Grant GH, et al. Colorimetric analysis of albumin by Bromocresol-green method. Amino acids and proteins. Fundamentals of Clinical Chemistry, Tietz 1987;328-329
  16. Fossati P, Principe L, Berti G. Enzymatic colorimetric method of uric acid analysis. Clin Chem 1980;26:227-231
  17. Ray-Sarker BC and Cahuhan UPS. Colorimetric(o-cresolphthalein complexone) method of total calcium analysis. Anal Biochem 1967;20:155
  18. Henry RJ. Inorganic phosphate analysis by Molybdate UV method. Clinical Chemistry Principles and Techniques. And Edition, Harper and Row 1974; p525
  19. Hollis Editorial: The Determination of circulating 25-hydroxyvitamin D: No Easy Task BW J Clin Endocrinol Metab, 2004;89:3149-3151
  20. Chand RB, Shah AK, Pant DK, Paudel S. Common site of urinary calculi in kidney, Ureter and bladder region. Nepal Med Coll J 2013;15:5-7
  21. Monu JU. Pattern of urolithiasis in Benin City, Nigeria. J Natl Med Assoc 1989;81:695-698
  22. Yung-Tai Chen AB. Urolithiasis Update: Evaluation and management, CME Credits. Department of Urology; Taiwan Adventist Hospital, Taipei, Taiwan
  23. Meka IA, Ugonabo MC, Ebede SO, Agbo EO. Composition of urolithiasiss in a tertiary hospital in South East Nigeria. Afri Health Sci 2018;18:437-445.
  24. Danjem SM, Salaam AJ, Kolade-Yunusa HO, Shuaibu SI. Common Site of Urinary Calculi in Kidney, Ureter and Urinary Bladder Region: Jos Experience. International Journal of Scientific Research and Management(IJSRM) 2019;07:275-283
  25. Gyasi-Sarpong, Maison, Adofo, Arhin, Azorliade, Amoah. Epidemiology of Upper Tract Urolithiasis and ESWL Treatment in Kumasi, Ghana. International Journal of Medical Science and Clinical Invention 2019; 6: 4570-4573
  26. Khan AS, Rai ME, Gandapur, Pervaiz A, Shah AH, Hussain AA, Siddiq M. Epidemioloical risk factors and composition of urinary stones in Riyadh Saudi Arabia. J Ayub Med Coll Abbottaba 2004;16:56-58
  27. Jennifer Hilgeri, Angelika Friedel, Raphael Herri, Tamara Rauschi, Franz Roos, Denys A Wahl, Dominque D Pierroz, Peter Weber and Kristina Hoffmann. A systematic review of vitamin D status in populations worldwide. British Journal of Nutrition 2014; 111:23-45
  28. Gharaibeh MA and Stoecker BJ. Assessment of serum 25(OH)D concentration in women of childbearing age and their preschool children in Northern Jordan during summer. Eur J Clin Nutr 2009;63:1320-1326
  29. Michelle RC, Brad RG, Kevin MB, Kaushal HS. Renal Calculi: Emergency Department Diagnosis and Treatment. FACEP Emergency Medicine Practice 2011;13:1-18
  30. Schlingmann KP, Kaufmann M, Weber S, Irwin A, Goos C, John U, et al. Mutations in CYP24A1 and idiopathic infantile hypercalcaemia. N Engl J Med 2011;365:410-421
  31. Dinour D, Davidovits W, Aviner S. Maternal and infantile hypercalcaemia caused by vitamin-D-hydroxylase mutations and vitamin D intake. Pediatr Nephrol 2015;30:145-152
  32. Schlingmann KP, Ruminska J, Kaufmann M, Dursun I, Patti M, Kranz B, et al. Autosomal-recessive mutations in SLC34A1 encoding sodium-phosphate cotransporter 2A cause idiopathic infantile hypercalcemia. J Am Soc Nephrol 2016; 27:604-614
  33. Beara-Lasic L, Edvardsson VO, Palsson R, Lieske JC, Goldfarb DS, Milliner DS. Genetic causes of kidney stones and kidney failure. Clin Rev Bone Miner Metab 2012;10:2-18
  34. Ruttchik SD, Resnick MI. Cystine calculi. Diagnosis and management. Urol Clin North Am 1997;24:163-171
  35. Edvardsson V, Elidottir H, Indridason OS, Palsson R. High incidence of kidney stones in Icelandic children. Pediatr Nephrol 2005;20:940-944
  36. C Perez-Barrios, E Hernandez-Alvarez, I Blanco-Navarro, B Perez-Sacristan, F Grando-Lorencio. Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. 2016DO:https://doi.org/10.1016/j.clnu.2016.02.017
  37. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-856
  38. Heaney RP, Dowell WS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin J Am Coll Nutr 2003;22:142-146
  39. Laufey S, Orvar G, Olafur SI, Leifur F, Pharm Gunnar S. Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium intake. JAMA 2005;294:2336-2341
  40. Gregory J and Robert JU. Physiological regulation of phosphate by vitamin D, parathyroid hormone(PTH) and phosphate(Pi). European Journal of Physiology 2019;471:83-98

How to Cite :

Spectrum of 25 (OH) D3 Status in Urinary Tract Stone Formers in North-Eastern Nigeria. Mshelia D.S., Gali R.M., Dogo H.M., Ummate I., Ibrahim A.G., Musa A.H., Dungus M.M., Bukar B., Genesis R.Y. , 5(6), 1839-1849. Retrieved from https://ijcsrr.org/single-view/?id=6297&pid=6268

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