Abstract :

The study synthesized a supramolecular complex of glycyrrhizic acid and β -indolyl-3-acetic acid in a 4:1 ratio isolated from the root of the plant licorice (Glycyrrhiza glabra L.). The resulting GA:IAA (4:1) complex was chemically identified based on the comparison of IR – Fure spectra of the starting agents.

---

Keywords :

Glycyrrhiza L., glycyrrhizic acid, IR-spectroscopy, Supramolecular complex., β -indolyl-3-acetic acid

---

References :

1. Astafieva O.V., Sukhenko L.T., Egorov M.A. Antimicrobial activity of isolated biologically active substances and root extract of Glycyrrhiza glabra L. // Chemistry of plant raw materials. – 2013. – No. 3. – P.261–263.
2. Borisenko S.N., Vetrova E.V., Lekar A.V., Filonova O.V., Borisenko N.I. Mass spectrometry of supramolecular complexes of glycyrrhetinic acid with the antibiotic streptocid // Chemistry of vegetable raw materials. – 2015. – No. 3. – P.127–134.
3. Brezhneva T.A., Maltseva A.A., Boeva ​​S.A., Slivkin A.I., Mironenko N.V. Investigation of the possibility of quantitative determination of triterpene saponins by UV spectrophotometry // Vestnik VGU (Series: Chemistry. Biology. Pharmacy). – 2007. – No. 2. – P.142–143.
4. Garmaeva E.A. Development and standardization of a complex herbal remedy recommended for the prevention of prostatitis // Abstract of the thesis. … Ph.D. – Ulan-Ude, 2007. – P.3-20.
5. Kamnev A.A., Perfiliev Yu.D. Physicochemical and ecological aspects of the interaction of indolyl-3-acetic acid with iron(III) // Vestn. Moscow university Ser. 2. Chemistry. – 2000. – T.41. – No. 3. – P.205–210.
6. Kondratenko R.M. Glycyrrhizic acid and related triterpenoids of licorice root in the synthesis of promising biologically active compounds // Abstract of the thesis. … d.c. – Ufa, 2006. – P.3–19.
7. Krakhmalev I.S., Gubanova L.B., Khadzhieva Z.D. Development of methods for qualitative and quantitative analysis of a spray based on thick extracts of eucalyptus rod and licorice // Pharmaceutical Sciences. Basic research. – 2012. – No. 5. – P.431–435.
8. Maistrenko V.N., Gusakov V.N., Rusakov I.A. et al. Complex formation of glycyrrhizic acid with 5-nitro-8-hydroxyquinoline and trinitroglycerin // Reports of the Academy of Sciences. – 1994. – Т.335(3). – P.329–331.
9. Polovyanenko D.N. Supramolecular complexes “guest-host” with the participation of spin traps and nitroxide radicals // Author’s diss. … PhD in Physics and Mathematics – Novosibirsk, 2009. – P.4–19.
10. Stolyarova O.V., Farrakhova G.F., Baltina L.A., Gabbasov T.M., Bashirova R.M., Kondratenko R.M., Baltina L.A. Isolation of glycyrrhizic acid and its monoammonium salt from the roots and rhizomes of Korzhinsky licorice (Glycyrrhiza korshinskyi Grig) // Bulletin of the Bashkir University. – 2008. – V.3. – No. 2. – P.256–258.
11. Tolstikov G.A., Murinov Yu.I., Baltina L.A. and others. Complexes (3 glycyrrhizic acid with prostaglandins. A new class of uterotonic active substances // Chemical Pharmaceutical Journal. – 1991. – V.25(3). – P.42–44.
12. Tolstikova T.G., Tolstikov A.G., Tolstikov G.A. On the way to low-dose drugs // Bulletin of the Russian Academy of Sciences. – 2007. – T.77. – No. 10. – P.867–874.
13. Khaitbaev A.Kh. Supramolecular complex of megosin // Proceedings of the IX International Symposium “Phenolic Compounds: Fundamental and Applied Aspects”. – Moscow, 2015. – P.155–158.
14. Shlotgauer A.A. Investigation of the interaction of atorvastatin with triterpene glycoside glycyrrhizic acid by NMR relaxation in solutions // Fundamental research. – 2013. – No. 10–3. – P.553–556.
15. Yakovshin L.A. Molecular complexes of triterpene glycosides with biologically active substances: Preparation, chemical-pharmaceutical properties and biological activity // Diss. … for the competition of a scientist. Art. Doctor of Chemical Sciences – Sevastopol, 2018. – P.10-238.
16. Groen J., Pelser H., Frenkel M. et al. Effect of glycyrrhizinic acid on the electrolyte metabolism in Addison’s disease // Journal of Clinical Investigation. – 1952. – V.31(l). – P.87–91.
17. Gusakov V.N., Maistrenko V.N., Saflullin P.P. Thermodynamics of formation of molecular complexes of aromatic nitro derivatives with lincomycin and P–glycyrrhizic acid // Russian Journal of General Chemistry. – 2001. – V.71(8). – P.1307–1310.
18. Kamnev A.A., Shchelochkov A.G., Perfilev Yu.D., Tarantilus P.A., Polissiou M.G. Spactroscopic investigation of indole–3–acetic acid interaction with iron(III) // J. Mol. Struct. – 2001. – P.565–572.
19. Marsh C.A., Lewy G.A. Glucuronide metabolism in plants. 3. Triterpene glucuronides // Journal of Biochemistry. – 1955. – V.63(1). – P.9–14.
20. Matchanov A.D., Zaynutdinov U.N., Islаmov A.K.H., Vypova N.L., Tashpulatov F.N., Matchanov U.D. Supramolecular Complexes of glycyrrhizic acid, its monoammonium salt with diterpenoid lagochilin and their hemostatic activity // Biochem Ind. J. – 2017. – V.11(4). – P.1–5.