Abstract :

The main aims of this manuscript are to: i) investigate the high drug loading of cefazolin and its characterization, ii), demonstrate the bioactivity of the cefazolin particles in vitro on Staphylococcus aureus. From our results, it is observed that the cefazolin loading into MCM-41 particles is 34 wt %. Furthermore, particles showed the burst release of cefazolin at pH 6.8.  At higher concentration, MCM-41 particles are comparatively more cytotoxic as compared to lower concentration. Finally, cefazolin loaded particles showed higher in vitro antibacterial activity against Staphylococcus aureus as compared to cefazolin only.

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Keywords :

antibiotics, cefazolin, drug delivery, MCM-41, mesoporous silica nanoparticles

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