Abstract :

Introduction: Human Immunodeficiency Virus (HIV) remains a global health problem, especially in high-risk groups of men who have sex with men (MSM). Pre-Exposure Prophylaxis (PrEP) is an effective HIV prevention strategy, but its success is highly dependent on the level of adherence to use.

Objective: This study aims to analyse the effect of education and motivation on non-adherence to PrEP use in men who have sex with men in Kemiling District, Bandar Lampung, Indonesia.

Methods: This study used an observational analytical design with a cross-sectional approach conducted in January–February 2026 with a sample of 64 respondents selected using proportional random sampling. Data were collected through a structured questionnaire, with non-adherence measured using the MMAS-8, and analysed using the Chi-Square test.

Results: The results showed that education (p=0.016; OR=4.427; 95% CI: 1.441–13.602) and motivation (p=0.003; OR=6.240; 95% CI: 1.923–20.248) significantly influenced non-adherence to PrEP use. Respondents with higher education and good motivation tended to be more adherent compared to respondents with lower education and less motivation.

Conclusion: It can be concluded that education and motivation are important factors influencing non-adherence to PrEP use. Therefore, interventions that emphasize increasing health literacy and strengthening motivation through ongoing education and counselling are needed to improve PrEP adherence in the MSM population.

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Keywords :

Education, HIV, Motivation, non-adherence, PrEP.

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