Abstract :
People with Autism Spectrum Disorder (ASD) constitute a specific group, characterized by neurobiological developmental alterations in systemic development at the level of psycho- cerebral information processing, which affects men at a higher prevalence of 3–4 men for every woman, although little research has been conducted into the causes of this difference. This study aims to analyze, where applicable, whether there are possible differences in the gender variable (men and women) in relation to the etiological basis and subsequent behavior or profile. To this end, a total of 116 participants with ASD took part, comprising 87 men and 29 women, who agreed to answer the questions posed in a questionnaire-interview. As can be seen from the results, it can be concluded that, in relation to the determining statistic of the KMO and Bartlett’s Test factor analysis, the group of men presents a greater explanatory load with regard to the genetic burden associated with the 15q11-q13 chromosomal region (sig: .02); whilst the ‘diseaseway’ variable shows a greater explanatory load in the women’s group in the coefficients of the linear regression analysis, with a significance level of 0.02 in the determinant statistics.
However, in no case can significant general differences in the diagnostic process be corroborated between the codes; yet, the coping component in relation to the genetic burden and/or early-onset diseases is clearly differential in the codes of the “gender” variable, which may lead to confusion with current analyses of the diagnostic process.
Keywords :
autism spectrum disorder, behavioral differences related to ‘gender’, differences in diagnosis between men and women with ASD, early-life illnesses and autism, environmental and organic factors within the family., genetics and autismReferences :
- Albein-Urios, N., Youssef, G. J., Kirkovski, M., & Enticott, P. G. (2018). Autism spectrum traits linked with reduced performance on self-report behavioural measures of cognitive flexibility. Journal of Autism and Developmental Disorders, 48, 2506–2515. https://doi.org/10.1007/s10803-018-3503-3
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, fifth edition (DSM-V). American Psychiatric Association. (Vol. 5). American Psychiatric Association. https:// doi. org/ 10. 1176/ appi. books. 97808 90425 596
- Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6(6), 248–254. https ://doi.org/10.1016/S1364 -6613(02)01904 -6.
- Baron-Cohen, S. (2009). Autism: The empathizing-systemizing (E-S) theory. Annals of the New York Academy of Sciences, 1156(1), 68–80. https ://doi.org/10.1111/j.1749-6632.2009.04467.x.
- Bolte, S., Duketis, E., Poustka, F., & Holtmann, M. (2011). Sex differences in cognitive domains and their clinical correlates in higherfunctioning autism spectrum disorders. Autism, 15(4), 497–511. https ://doi.org/10.1177/13623 61310 391116.
- Cerliani, L., Mennes, M., Thomas, R. M., Di Martino, A., Thioux, M., & Keysers, C. (2015). Increased functional connectivity between subcortical and cortical resting-state networks in autism spectrum disorder. JAMA Psychiatry, 72(8), 1–11. https:// doi. org/ 10. 1001/jamap sychi atry. 2015. 0101
- Demetriou, E. A, Pepperm K. L., Park, S. H., Pellicano, L., Song, Y. Y., Naismity, S. L., Hickie, I. N., Thomas, E. E., & Guastella, A. J., Hickie, I. B., Thomas. E. E., & Guastella, A. J. (2021). Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function. Autism, 25(8) 2223–2237. DOI: 10.1177/13623613211014991.journals.sagepub.com/home/aut. https://pubmed.ncbi.nlm.nih.gov/34169770/
- Dworzynski, K., Ronald, A., Bolton, P., & Happé, F. (2012). How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? Journal of the American Academy of Child and Adolescent Psychiatry, 51(8), 788–797. https ://doi.org/10.1016/j.jaac.2012.05.018.
- Ferri, S. L., Abel, T., & Brodkin, E. S. (2018). Sex differences in autism spectrum disorder: A review. Current Psychiatry Reports, 20(2), 9. https://doi.org/10.1007/s11920-018-0874-2
- Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014). Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. Journal of the American Academy of Child and Adolescent Psychiatry, 53(3), 329–340.e323. https://doi.org/10.1016/j.jaac.2013.12.004
- Frith, U. (1989). A new look at language and communication in autism. The British Journal of Disorders of Communication, 24(2), 123–150. https://pubmed.ncbi.nlm.nih.gov/2690916/
- Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011). Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron, 70(5), 898–907. https ://doi.org/10.1016/j.neuro n.2011.05.021.
- Koenig, K., & Tsatsanis, K. D. (2005). Pervasive developmental disorders in girls. In Handbook of behavioral and emotional problems in girls (pp. 211–237). Boston, MA: Springer. https ://doi.org/10.1007/0-306-48674 -1_7
- Kreiser, N. L., & White, S. W. (2014). ASD in females: Are we overstating the gender difference in diagnosis? Clinical Child and Family Psychology Review, 17(1), 67–84. https://doi.org/10.1007/s10567-013-0148-9
- Loomes, R., Hull, L., & Mandy, W. P. L. (2017). What Is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 56(6), 466–474. https://doi.org/10.1016/j.jaac.2017.03.013
- Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2012). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313. https://doi.org/10.1007/s1080 3-011-1356-0.
- Øien, R. A., Hart, L., Schjølberg, S., Wall, C. A., Kim, E. S., Nordahl-Hansen, A., Eiseman, M. R., Chawarska, K., Volkmar, F. R., & Shic, F. (2017). Parent-endorsed sex differences in toddlers with and without ASD: Utilizing the M-CHAT. Journal of Autism and Developmental Disorders, 47(1), 126–134. https ://doi.org/10.1007/s1080 3-016-2945-8.
- Øien, R. A., Vambheim, S. M., Hart, L., Nordahl‑Hansen, A., Erickson, C., Wink, L., Eisemann, M. R., Shic, F., Volkmar, F. R., & Grodberg, D. (2018). Sex-differences in children referred for sssessment: An exploratory analysis of the Autism Mental Status Exam (AMSE). Journal of Autism and Developmental Disorders, 48, 2286–2292. https://pubmed.ncbi.nlm.nih.gov/29423603/
- Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991). Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind. Journal of Child Psychology and Psychiatry, 32(7), 1081–1105. https:// doi. org/ 10. 1111/j. 1469- 7610. 1991.tb003 51.x
- Pellicano, E. (2007). Links between theory of mind and executive function in young children with autism: Clues to developmental primacy. Developmental Psychology, 43(4), 974–990. https://pubmed.ncbi.nlm.nih.gov/17605529/
- Prat, C. S., Stocco, A., Neuhaus, E., & Kleinhans, N. M. (2016). Basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex. Neuropsychologia, 91, 268–281. https:// doi. org/ 10.1016/j. neuro psych ologia. 2016.08. 007
- Reilly, D., Neumann, D. L., & Andrews, G. (2016). Sex and sex-role differences in specific cognitive abilities. Intelligence, 54, 147–158. https://doi.org/10.1016/j.intell.2015.12.004
- Robinson, E. B., Lichtenstein, P., Anckarsäter, H., Happé, F., & Ronald, A. (2013). Examining and interpreting the female protective effect against autistic behavior. Proceedings of the National Academy of Sciences USA, 110(13), 5258–5262. https ://doi.org/10.1073/pnas.12110 70110
- Shirer, W. R., Ryali, S., Rykhlevskaia, E., Menon, V., & Greicius, M. D. (2012). Decoding subject-driven cognitive states with wholebrain connectivity patterns. Cerebral Cortex, 22(1), 158–165. https:// doi. org/ 10. 1093/ cercor/ bhr099
- Skuse, D. H. (2000). Imprinting, the X-chromosome, and the male brain: Explaining sex differences in the liability to autism. Pediatric Research, 47, 9. https://doi.org/10.1203/00006450-200001000-00006
- Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., & Beckmann, C. F. (2009). Correspondence of the brain’s functional architecture during activation and rest. Proceedings of the National Academy of Sciences of the United States of America, 106(31), 13040–13045. https:// doi. org/ 10. 1073/ pnas. 09052 67106
- Subramanian, K., Brandenburg, C., Orsati, F., Soghomonian, J.-J., Hussman, J. P., & Blatt, G. J. (2017). Basal ganglia and autism a translational perspective. Autism Research, 10(11), 1751–1775. https:// doi. org/ 10. 1002/ aur. 1837
- Szatmari, P., Liu, X.-Q., Goldberg, J., Zwaigenbaum, L., Paterson, A. D., Woodbury-Smith, M., et al. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(1), 5–12. https://doi.org/10.1002/ajmg.b.31238 .
- Tavares, V., Fernandes, L. A., Antunes, A., Ferreira, H., & Prata, D. (2022). Sex differences in functional connectivity between resting state brain networks in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 52, 3088–3101. https://doi.org/10.1007/s10803-021-05191-6
- Van Wijngaarden-Cremers, P. J. M., van Eeten, E., Groen, W. B., Van Deurzen, P. A., Oosterling, I. J., & Van der Gaag, R. J. (2014). Gender and age differences in the core triad of impairments in autism spectrum disorders: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(3), 627–635. https://doi.org/10.1007/s10803-013-1913-9
- Vasa, R. A., Mostofsky, S. H., & Ewen, J. B. (2016). The disrupted connectivity hypothesis of autism spectrum disorders: Time for the next phase in research. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(3), 245–252. https:// doi. org/ 10.1016/j. bpsc. 2016. 02. 003
- Wallace, G. L., Kenworthy, L., Pugliese, C. E., Popal, H. S., White, E. I., Brodsky, E., & Martin, A. (2016). Real-world executive functions in adults with autism spectrum disorder: Profiles of impairment and associations with adaptive functioning and co-morbid anxiety and depression. Journal of Autism and Developmental Disorders, 46(3), 1071–1083. https://doi.org/10.1007/s10803-015-2655-7

