Abstract :

The skin is one of the most extensive and readily accessible organs of the human body, and its use as a route for drug delivery offers numerous advantages over traditional drug delivery systems. These advantages include lower fluctuations in plasma drug levels, avoidance of gastrointestinal disturbances and first-pass metabolism, as well as improved patient compliance. Transdermal drug delivery systems (TDDS) are defined as self-contained, discrete dosage forms that, when applied to intact skin, deliver of drugs at the controlled rate to the systemic circulation Ethosomes, developed from Touitou et al. in 1997, are novel lipid carriers composed of ethanol, phospholipids and water. These ethosomes are designed as non-invasive drug carrier system that can permeate the skin, fuse with cell membrane lipids, and release the drug. Ethosomes can be formulated using either hot or cold methods. Evaluation parameters for ethosomes include size, shape, drug content and zeta potential. Ethosomes have been successfully evaluated for the delivery of various drugs, including cyclosporine a insulin and salbutamol. Overall, ethosomes hold great potential as an important drug delivery tool in the future.

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Keywords :

drug delivery, Ethosomes, Lipid carriers, Skin permeation, Transdermal.

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References :

1. Nandure HP, Puranik P, Giram P, Lone V. Ethosome: A Novel Drug Carrier. Int. J. pharm. Res. & allied sci. 2013 1;2(3).
2. Chauhan N, Vasava P, Khan SL, Siddiqui FA, Islam F, Chopra H, Emran TB. Ethosomes: A novel drug carrier. Annals of Medicine and Surgery. 2022 1;82.
3. Selvam RP, Singh AK, Sivakumar T. Transdermal drug delivery systems for antihypertensive drugs-A review. Int J Pharm Biomed Res. 2010;1(1):1-8.
4. David S, Hui MS, Pin CF, Ci FY, Rajabalaya R. Ethosomes as vesicular carrier for enhanced topical delivery of isotretinoin. Int. J. Cosmet Sci. 2012;34(4):365.
5. Aute PP, Kamble MS, Chaudhari PD, Bhosale AV. A comprehensive review on ethosomes. Int. J Res and Devt in pharmacy & life sciences. 2012 15;2(1):218-24.
6. Verma P, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: An overview. JAPTR. 2010 1;1(3):274-82.
7. Satyam G, Shivani S, Garima GJ. Ethosomes: A novel tool for drug delivery through the skin. J Pharm Res. 2010 ;3(4):688-91.
8. Maurya SD, Prajapati S, Gupta A, Saxena G, Dhakar RC. Formulation development and evaluation of ethosome of stavudine. Int J Pharm Edu Res. 2010;13(01):16-22.
9. Chen JG, LaI W, JIANG Y. Preparation of curcumin ethosomes. Afr. J. Pharm. Pharmacol. 2013; 7:2246-51.
10. Sangeetha S. Ethosomes: A novel drug delivery system and their therapeutic applications-A review. Res J pharmacy and techn. 2020;13(4):1972-80.