Abstract :
Introduction: Cancer staging is an important aspect of cancer management and directly affects the treatment plan of the patient. There are several protein tumour markers that helps in the diagnosis as well as prognosis of cancer patients.
Aim: The current study aims to evaluate the total protein value from the serum samples of selected cancer patients and see any pattern with different stages of patients.
Materials & Method: Total proteins were measured by IR-VS spectroscopy method and compared in different patients.
Result: The spectrophotometric analysis of the collected serum samples showed that chemotherapy induced total protein loss is associated with dysregulation in serum proteins and electrolytes. Total protein is a significant marker that can help determine the tumour staging in cancer patients and thus can act as a prognostic marker also. It is a simple, non-invasive and cost effective method of analysis.
Keywords :
Cancer, Chemotherapy., Markers, Spectrophotometry, Total Protein., TumourReferences :
- Bommer UA. The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation. Results Probl Cell Differ. 2017; 64: 69-126.
- Rasouli M, Okhovatian A, Enderami A. Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses. Clin Chem Lab Med. 2005; 43(9):913-8.
- Ulrich-Axel Bommer, Bernd-Joachim Thiele, The translationally controlled tumour protein (TCTP), The International Journal of Biochemistry & Cell Biology, Volume 36, Issue 3, 2004, Pages 379-385.
- Whiteside TL. Tumor-Infiltrating Lymphocytes and Their Role in Solid Tumor Progression. Exp Suppl. 2022; 113: 89-106.
